SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 8 PHE A 185
SER A  61
ILE A  64
LEU A  73
 None
 0.84A 1eupA-2cb4A:
undetectable		 1eupA-2cb4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 11 LEU A  73
GLY A 203
GLY A 202
ILE A 139
ILE A 179
 None
 0.94A 1sduA-2cb4A:
undetectable		 1sduA-2cb4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 8 ASP A 273
ILE A 139
GLY A 202
GLY A 203
ILE A 204
 None
 1.30A 1sguA-2cb4A:
undetectable		 1sguA-2cb4A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 12 ASP A 237
TYR A 213
ILE A 225
PHE A 248
SER A 245
 None
 1.29A 1xmuA-2cb4A:
undetectable		 1xmuA-2cb4A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 8 ALA A  44
PHE A 200
ALA A 175
LEU A  95
 None
 0.78A 2bxmA-2cb4A:
undetectable		 2bxmA-2cb4A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 5 PHE A 107
ILE A 230
ASN A 252
PHE A 229
 None
 1.40A 3octA-2cb4A:
undetectable		 3octA-2cb4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 12 ASP A 273
ILE A 139
ASP A 105
ASP A  99
ARG A  97
 None
 1.05A 3phaB-2cb4A:
undetectable		 3phaB-2cb4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 12 ASP A 273
ILE A 139
ASP A 105
ASP A  99
ARG A  97
 None
 1.02A 3phaC-2cb4A:
undetectable		 3phaC-2cb4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		5 / 12 ASP A 273
ILE A 139
ASP A 105
ASP A  99
ARG A  97
 None
 1.06A 3phaD-2cb4A:
undetectable		 3phaD-2cb4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		3 / 3 ARG A  94
GLU A 154
ASN A  91
 None
 0.87A 4imaD-2cb4A:
undetectable		 4imaD-2cb4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		3 / 3 ARG A  94
GLU A 154
ASN A  91
 None
 0.81A 4ip7D-2cb4A:
undetectable		 4ip7D-2cb4A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 7 ASN A 280
PRO A 279
PHE A 192
TRP A 158
 None
 1.09A 5amhA-2cb4A:
0.0		 5amhA-2cb4A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		3 / 3 TYR A 215
SER A 293
TRP A  98
 None
 1.03A 5n8jB-2cb4A:
undetectable		 5n8jB-2cb4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 6 GLU A 154
ARG A 170
TYR A 148
SER A 239
 None
 1.02A 5phhA-2cb4A:
undetectable		 5phhA-2cb4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 2cb4 MOSQUITOCIDAL TOXIN
(Lysinibacillus
sphaericus) 		4 / 6 ARG A  76
PHE A 140
PHE A 200
ILE A  41
 None
 1.11A 5vceA-2cb4A:
undetectable		 5vceA-2cb4A:
21.98