SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		6 / 11 GLU A 256
HIS A 257
LEU A 251
GLU A 252
PHE A 231
ILE A 245
 None
 1.41A 1rnrA-2cb5A:
undetectable		 1rnrA-2cb5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		5 / 12 GLU A 256
HIS A 257
LEU A 251
GLU A 252
PHE A 231
 None
 1.37A 1rnrB-2cb5A:
undetectable		 1rnrB-2cb5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		6 / 10 GLN A  67
GLY A  71
TRP A  74
PHE A  76
HIS A 372
ALA A 373
 None
 0.51A 1stfE-2cb5A:
9.0
1stfI-2cb5A:
0.0		 1stfE-2cb5A:
17.61
1stfI-2cb5A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 MET A 149
GLU A 421
ASP A 273
 None
 0.81A 3a25A-2cb5A:
undetectable		 3a25A-2cb5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		4 / 7 GLN A  67
GLY A  71
HIS A 372
TRP A 398
 None
 0.41A 3ai8A-2cb5A:
13.0		 3ai8A-2cb5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		5 / 12 PHE A 415
THR A 377
VAL A  57
VAL A 419
LEU A 308
 None
 1.33A 3elzA-2cb5A:
undetectable		 3elzA-2cb5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 GLY A  31
THR A  33
ASN A  29
 None
 0.71A 3v4tD-2cb5A:
undetectable		 3v4tD-2cb5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 CYH A 111
ASN A 182
LYS A 107
 None
 1.29A 4k50A-2cb5A:
undetectable		 4k50A-2cb5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 HIS A 257
GLY A 246
ILE A 248
 None
 0.53A 4k50A-2cb5A:
undetectable		 4k50A-2cb5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 HIS A 257
GLY A 246
ILE A 248
 None
 0.52A 4k50I-2cb5A:
undetectable		 4k50I-2cb5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		5 / 12 TRP A  74
THR A 170
MET A 177
ASN A 178
GLU A 167
 None
 1.14A 4zvmA-2cb5A:
undetectable
4zvmB-2cb5A:
undetectable		 4zvmA-2cb5A:
18.48
4zvmB-2cb5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		3 / 3 VAL A 433
HIS A 428
VAL A 424
 None
 0.67A 5jmnC-2cb5A:
undetectable		 5jmnC-2cb5A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		5 / 12 ASN A 272
VAL A 271
GLY A 325
SER A  73
GLN A  67
 None
 1.46A 5lsaA-2cb5A:
undetectable		 5lsaA-2cb5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens) 		4 / 8 TRP A 147
TYR A 254
GLU A 155
ASN A 263
 None
 1.09A 6c71B-2cb5A:
undetectable		 6c71B-2cb5A:
11.01