SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cb9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		4 / 6 HIS A 201
ALA A 112
GLY A  82
TYR A  83
 ACY  A1225 (-3.9A)
None
None
None
 1.08A 1c8lA-2cb9A:
6.0		 1c8lA-2cb9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 11 CYH A  26
LEU A 205
LEU A  44
VAL A 110
ILE A 220
 None
 1.27A 1ee2A-2cb9A:
3.0		 1ee2A-2cb9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 11 CYH A  26
LEU A 205
LEU A  44
VAL A 110
ILE A 220
 None
 1.28A 1ee2B-2cb9A:
undetectable		 1ee2B-2cb9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		4 / 6 HIS A 201
ALA A 112
GLY A  82
TYR A  83
 ACY  A1225 (-3.9A)
None
None
None
 1.09A 1gfzA-2cb9A:
6.0		 1gfzA-2cb9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		4 / 6 VAL A  94
ILE A 109
ILE A 160
ASP A 106
 None
 0.83A 1uwhB-2cb9A:
undetectable		 1uwhB-2cb9A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 ILE A  30
GLY A  34
GLY A  32
ASN A  17
LEU A  44
 ACY  A1225 ( 4.7A)
None
None
None
None
 1.04A 2y7hB-2cb9A:
undetectable		 2y7hB-2cb9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		4 / 6 HIS A 201
ALA A 112
GLY A  82
TYR A  83
 ACY  A1225 (-3.9A)
None
None
None
 1.11A 3dd1B-2cb9A:
0.6		 3dd1B-2cb9A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 0.98A 3s8pA-2cb9A:
undetectable		 3s8pA-2cb9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 0.99A 3s8pB-2cb9A:
undetectable		 3s8pB-2cb9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 1.00A 4bupA-2cb9A:
undetectable		 4bupA-2cb9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 0.98A 4bupB-2cb9A:
0.0		 4bupB-2cb9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 PHE A  37
GLU A 206
ALA A 210
ALA A 200
GLY A 199
 None
 1.09A 4oaeA-2cb9A:
1.9		 4oaeA-2cb9A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A  86
GLU A  58
ALA A 152
ILE A  62
TYR A  65
 None
 0.98A 5igvA-2cb9A:
undetectable		 5igvA-2cb9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 1.02A 5wbvA-2cb9A:
undetectable		 5wbvA-2cb9A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2cb9 FENGYCIN SYNTHETASE
(Bacillus
subtilis) 		5 / 12 GLY A 199
ALA A 200
SER A  84
TYR A 113
PHE A 166
 None
None
ACY  A1225 (-2.5A)
None
None
 1.03A 5wbvB-2cb9A:
undetectable		 5wbvB-2cb9A:
21.89