SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		3 / 3 THR A 179
LEU A 244
VAL A 208
 None
 0.58A 1mz9E-2cbfA:
undetectable		 1mz9E-2cbfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 7 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.69A 2jn3A-2cbfA:
undetectable		 2jn3A-2cbfA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
 1.07A 2yqzA-2cbfA:
3.3		 2yqzA-2cbfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
 1.05A 2yqzB-2cbfA:
3.3		 2yqzB-2cbfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 THR A  37
GLY A 102
GLY A 129
LEU A  35
VAL A  57
 None
SAH  A 300 (-3.4A)
None
None
None
 1.22A 3fzgA-2cbfA:
undetectable		 3fzgA-2cbfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.4A)
None
None
None
None
 1.07A 3g89A-2cbfA:
undetectable		 3g89A-2cbfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 11 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.4A)
None
None
None
None
 1.07A 3g89B-2cbfA:
undetectable		 3g89B-2cbfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.4A)
None
None
None
None
 1.09A 3g8bA-2cbfA:
undetectable		 3g8bA-2cbfA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 10 TRP A 247
THR A 150
VAL A 153
ILE A 154
ILE A 180
 None
 1.28A 3kpbD-2cbfA:
undetectable		 3kpbD-2cbfA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 10 LEU A 173
LEU A 155
ILE A 180
ALA A 181
THR A 150
 None
 1.37A 3r9cA-2cbfA:
undetectable		 3r9cA-2cbfA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 6 LEU A  44
THR A 101
ALA A  28
LEU A  41
 None
SAH  A 300 (-4.9A)
None
None
 0.96A 4pwjA-2cbfA:
undetectable		 4pwjA-2cbfA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 LEU A  43
ILE A  26
ASP A 103
GLY A 129
ILE A 126
 None
 1.24A 5j7wC-2cbfA:
undetectable		 5j7wC-2cbfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 7 LEU A 184
PHE A 183
THR A 131
THR A 189
 SAH  A 300 (-3.8A)
SAH  A 300 (-4.9A)
SAH  A 300 (-3.4A)
None
 1.00A 5vc0A-2cbfA:
undetectable		 5vc0A-2cbfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 GLY A  31
SER A  65
VAL A  50
VAL A  99
ASP A  54
 None
 1.40A 6bxlB-2cbfA:
2.0		 6bxlB-2cbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.17A 6mkeB-2cbfA:
undetectable		 6mkeB-2cbfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.28A 6mkeA-2cbfA:
undetectable		 6mkeA-2cbfA:
15.88