SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cbn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 5 THR A  20
GLU A 232
THR A 213
HIS A  66
 None
None
None
ZN  A 401 (-3.2A)
 1.10A 1d4fB-2cbnA:
undetectable		 1d4fB-2cbnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 ALA A 297
ILE A   4
VAL A 228
ILE A 267
 None
 0.70A 1d4yB-2cbnA:
undetectable		 1d4yB-2cbnA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 5 ASP A 212
HIS A 270
HIS A  64
HIS A  69
 ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 1.23A 1ei6A-2cbnA:
undetectable		 1ei6A-2cbnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 LEU A 105
ARG A  98
PHE A 100
GLY A  96
 None
 0.92A 1fapB-2cbnA:
undetectable		 1fapB-2cbnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 10 PRO A  74
GLY A  75
LEU A  36
THR A  43
GLY A  40
 None
 1.44A 1h4oA-2cbnA:
undetectable
1h4oB-2cbnA:
undetectable		 1h4oA-2cbnA:
19.67
1h4oB-2cbnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 6 PHE A   5
GLU A 295
LEU A 296
VAL A 271
 None
 1.04A 1hk1A-2cbnA:
undetectable		 1hk1A-2cbnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 7 PHE A   5
GLU A 295
LEU A 296
VAL A 271
 None
 0.92A 1hk2A-2cbnA:
undetectable		 1hk2A-2cbnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 ASP A 212
HIS A 270
HIS A 248
 ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
None
 0.69A 1oe1A-2cbnA:
undetectable		 1oe1A-2cbnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 ASP A 212
HIS A 270
HIS A 248
 ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
None
 0.68A 1oe3A-2cbnA:
undetectable		 1oe3A-2cbnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 5 LEU A  57
LEU A  34
LEU A  24
CYH A  39
 None
 1.04A 2ab2B-2cbnA:
undetectable		 2ab2B-2cbnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 6 THR A  16
THR A   8
THR A 234
ASP A 236
 None
 1.26A 2okcB-2cbnA:
undetectable		 2okcB-2cbnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 ASP A  68
HIS A  69
HIS A 141
ASP A 212
HIS A 270
 ZN  A 402 (-2.6A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
 0.72A 2q0jB-2cbnA:
10.1		 2q0jB-2cbnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 HIS A  69
HIS A 141
ASP A 212
HIS A 270
SER A 272
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
None
 0.97A 2q0jB-2cbnA:
10.1		 2q0jB-2cbnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 ASP A 212
HIS A 270
HIS A 248
 ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
None
 0.70A 2xxgA-2cbnA:
undetectable		 2xxgA-2cbnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 5 HIS A 141
HIS A 248
HIS A 270
ASP A  68
 ZN  A 401 (-3.4A)
None
ZN  A 402 (-3.3A)
ZN  A 402 (-2.6A)
 1.19A 3c0zA-2cbnA:
undetectable		 3c0zA-2cbnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 8 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.35A 3c0zB-2cbnA:
undetectable		 3c0zB-2cbnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 LEU A  73
GLY A  72
ILE A  60
ALA A  21
LEU A  57
 None
 0.98A 3gwvA-2cbnA:
undetectable		 3gwvA-2cbnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		6 / 12 GLY A   7
THR A  20
ASP A 299
PHE A 300
ILE A   4
ASP A  38
 None
 1.46A 3iv6B-2cbnA:
undetectable		 3iv6B-2cbnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 HIS A  69
THR A  20
THR A  43
ILE A  62
SER A  63
 ZN  A 402 (-3.3A)
None
None
None
None
 1.23A 3kpbC-2cbnA:
undetectable		 3kpbC-2cbnA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 LEU A  89
THR A  20
ILE A 118
ILE A 126
ALA A 136
 None
 1.18A 3nxuB-2cbnA:
undetectable		 3nxuB-2cbnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 ASP A 227
GLU A 151
GLY A 204
 None
 0.70A 3w9tA-2cbnA:
undetectable		 3w9tA-2cbnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 10 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.37A 4bz6A-2cbnA:
undetectable		 4bz6A-2cbnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.39A 4bz6A-2cbnA:
undetectable
4bz6B-2cbnA:
undetectable		 4bz6A-2cbnA:
21.65
4bz6B-2cbnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 10 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.38A 4bz6D-2cbnA:
undetectable		 4bz6D-2cbnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 10 HIS A  64
HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.77A 4c1dB-2cbnA:
9.0		 4c1dB-2cbnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 HIS A  64
HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.77A 4c1fA-2cbnA:
4.3
4c1fB-2cbnA:
9.3		 4c1fA-2cbnA:
22.40
4c1fB-2cbnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 9 HIS A  64
HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.78A 4c1hA-2cbnA:
9.9		 4c1hA-2cbnA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 9 HIS A  66
ASP A  68
HIS A  64
GLY A 247
HIS A 270
 ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
None
ZN  A 402 (-3.3A)
 1.27A 4c1hA-2cbnA:
9.9		 4c1hA-2cbnA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.70A 4exsB-2cbnA:
9.4		 4exsB-2cbnA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 ILE A  62
ASP A  38
THR A 269
VAL A 230
ILE A 209
 None
 1.40A 4i41A-2cbnA:
undetectable		 4i41A-2cbnA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.36A 4lxzB-2cbnA:
undetectable		 4lxzB-2cbnA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 7 HIS A 248
HIS A 270
HIS A  64
HIS A  66
 None
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
 0.95A 4p6sB-2cbnA:
undetectable		 4p6sB-2cbnA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 HIS A  69
HIS A  64
ASP A  68
HIS A  66
GLY A  67
 ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.2A)
None
 1.38A 4qa0B-2cbnA:
undetectable		 4qa0B-2cbnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 LEU A 116
LEU A 105
LEU A  57
ILE A  60
LEU A  47
 None
 1.03A 4zowA-2cbnA:
undetectable		 4zowA-2cbnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.70A 5a5zA-2cbnA:
8.9		 5a5zA-2cbnA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		6 / 11 HIS A  64
HIS A  66
ASP A  68
HIS A  69
HIS A 141
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.40A 5ayaA-2cbnA:
10.7		 5ayaA-2cbnA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 ILE A 209
ILE A  22
ASN A 304
ILE A 267
ALA A 297
 None
 1.07A 5lg3E-2cbnA:
undetectable		 5lg3E-2cbnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 ASP A 212
HIS A 270
HIS A 248
HIS A  64
 ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
None
ZN  A 401 (-3.4A)
 0.90A 5nekD-2cbnA:
undetectable		 5nekD-2cbnA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		6 / 10 HIS A  64
HIS A  66
HIS A  69
HIS A 141
ASP A 212
HIS A 248
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.2A)
ZN  A 402 (-3.3A)
ZN  A 401 (-3.4A)
ZN  A 402 ( 2.3A)
None
 0.34A 5nzwA-2cbnA:
12.0		 5nzwA-2cbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 10 HIS A 141
HIS A  64
HIS A 248
ASP A 212
HIS A 270
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.4A)
None
ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
 0.91A 5nzwA-2cbnA:
12.0		 5nzwA-2cbnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 HIS A  69
ASP A 212
HIS A 270
 ZN  A 402 (-3.3A)
ZN  A 402 ( 2.3A)
ZN  A 402 (-3.3A)
 0.80A 5oexA-2cbnA:
undetectable		 5oexA-2cbnA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 ILE A  22
ASP A 212
GLY A 211
ALA A  10
VAL A 271
 None
ZN  A 402 ( 2.3A)
None
None
None
 1.17A 5x66F-2cbnA:
undetectable		 5x66F-2cbnA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 THR A 234
GLU A 232
HIS A 141
 None
None
ZN  A 401 (-3.4A)
 0.75A 5xioA-2cbnA:
undetectable		 5xioA-2cbnA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 THR A 234
GLU A 232
HIS A 141
 None
None
ZN  A 401 (-3.4A)
 0.77A 5xiqB-2cbnA:
undetectable		 5xiqB-2cbnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		3 / 3 THR A 234
GLU A 232
HIS A 141
 None
None
ZN  A 401 (-3.4A)
 0.77A 5xiqD-2cbnA:
undetectable		 5xiqD-2cbnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 11 HIS A 141
HIS A 270
HIS A  69
SER A  63
HIS A  66
 ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
None
ZN  A 401 (-3.2A)
 1.46A 5z0gA-2cbnA:
undetectable
5z0gB-2cbnA:
undetectable		 5z0gA-2cbnA:
16.40
5z0gB-2cbnA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		4 / 8 HIS A  66
ASP A  68
HIS A 141
HIS A 270
 ZN  A 401 (-3.2A)
ZN  A 402 (-2.6A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.3A)
 0.74A 5zj8A-2cbnA:
9.4		 5zj8A-2cbnA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 HIS A 248
SER A 272
ALA A  10
HIS A 270
HIS A  69
 None
None
None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 1.24A 6n91A-2cbnA:
undetectable		 6n91A-2cbnA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2cbn RIBONUCLEASE Z
(Escherichia
coli) 		5 / 12 HIS A 248
SER A 272
ALA A  10
HIS A 270
HIS A  69
 None
None
None
ZN  A 402 (-3.3A)
ZN  A 402 (-3.3A)
 1.25A 6n91B-2cbnA:
undetectable		 6n91B-2cbnA:
16.04