SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		6 / 12 LEU A  28
ALA A  32
ALA A  35
THR A  54
THR A  56
ARG A  59
 A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
A80  A 201 (-4.8A)
 1.37A 1cbrA-2cbrA:
27.2		 1cbrA-2cbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		12 / 12 PHE A  15
LEU A  28
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
ARG A  59
LEU A 120
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
A80  A 201 (-4.8A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.43A 1cbrA-2cbrA:
27.2		 1cbrA-2cbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		6 / 12 LEU A  28
ALA A  32
ALA A  35
THR A  54
THR A  56
ARG A  59
 A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
A80  A 201 (-4.8A)
 1.37A 1cbrB-2cbrA:
27.3		 1cbrB-2cbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		12 / 12 PHE A  15
LEU A  28
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
ARG A  59
LEU A 120
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
A80  A 201 (-4.8A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.43A 1cbrB-2cbrA:
27.3		 1cbrB-2cbrA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		11 / 12 PHE A  15
LEU A  19
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
LEU A 120
ARG A 131
TYR A 133
 None
None
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.45A 1cbsA-2cbrA:
26.6		 1cbsA-2cbrA:
76.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
THR A  61
VAL A  58
 None
None
A80  A 201 ( 4.1A)
None
None
 0.91A 1cbsA-2cbrA:
26.6		 1cbsA-2cbrA:
76.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 LEU A  19
ALA A  32
ILE A  63
THR A  61
TRP A 109
 None
A80  A 201 ( 4.1A)
None
None
None
 0.89A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
ALA A  32
ILE A  52
THR A  54
TRP A 109
 None
A80  A 201 ( 4.1A)
None
A80  A 201 (-3.5A)
None
 0.82A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
ILE A  52
TRP A 109
 None
None
A80  A 201 ( 4.1A)
None
None
 0.94A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
ILE A  63
TRP A 109
 None
None
A80  A 201 ( 4.1A)
None
None
 0.90A 1crbA-2cbrA:
15.7		 1crbA-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
THR A  61
PHE A  71
 None
None
A80  A 201 ( 4.1A)
None
None
 0.87A 1mx8A-2cbrA:
16.7		 1mx8A-2cbrA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		11 / 12 PHE A  15
LEU A  19
ALA A  32
ALA A  36
PRO A  39
THR A  54
THR A  56
VAL A  58
LEU A 120
ARG A 131
TYR A 133
 None
None
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.47A 2fr3A-2cbrA:
26.9		 2fr3A-2cbrA:
76.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
THR A  61
VAL A  58
 None
None
A80  A 201 ( 4.1A)
None
None
 0.99A 2fr3A-2cbrA:
26.9		 2fr3A-2cbrA:
76.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		9 / 12 PHE A  15
LEU A  19
ALA A  32
THR A  54
THR A  56
VAL A  58
VAL A  76
ARG A 111
LEU A 120
 None
None
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
A80  A 201 (-3.3A)
None
None
None
None
 0.54A 2g78A-2cbrA:
26.9		 2g78A-2cbrA:
75.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		6 / 12 PHE A  15
LEU A  19
ALA A  32
THR A  61
VAL A  58
VAL A  76
 None
None
A80  A 201 ( 4.1A)
None
None
None
 1.37A 2g78A-2cbrA:
26.9		 2g78A-2cbrA:
75.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
ALA A  32
THR A  61
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.1A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.89A 2qm9A-2cbrA:
18.7		 2qm9A-2cbrA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
ALA A  32
THR A  61
CYH A 129
TYR A 133
 None
A80  A 201 ( 4.1A)
None
None
A80  A 201 (-4.7A)
 1.38A 2qm9A-2cbrA:
18.7		 2qm9A-2cbrA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
VAL A  24
ALA A  32
THR A  61
CYH A 129
 None
None
A80  A 201 ( 4.1A)
None
None
 1.22A 2qm9A-2cbrA:
18.7		 2qm9A-2cbrA:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 LEU A  28
PRO A  39
THR A  56
VAL A  58
ARG A  59
 A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.3A)
None
A80  A 201 (-4.8A)
 0.93A 3cwkA-2cbrA:
26.0		 3cwkA-2cbrA:
72.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		8 / 12 PHE A  15
LEU A  19
LEU A  28
ALA A  32
ALA A  36
PRO A  39
THR A  56
VAL A  58
 None
None
A80  A 201 ( 4.0A)
A80  A 201 ( 4.1A)
A80  A 201 ( 4.0A)
A80  A 201 ( 4.9A)
A80  A 201 (-3.3A)
None
 0.49A 3cwkA-2cbrA:
26.0		 3cwkA-2cbrA:
72.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
PRO A  39
ARG A 111
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.9A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 0.66A 3p6gA-2cbrA:
18.8		 3p6gA-2cbrA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
PRO A  39
CYH A 129
ARG A 131
TYR A 133
 None
A80  A 201 ( 4.9A)
None
A80  A 201 (-3.8A)
A80  A 201 (-4.7A)
 1.40A 3p6gA-2cbrA:
18.8		 3p6gA-2cbrA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
ALA A  32
THR A  54
TRP A 109
LEU A 120
 None
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
None
None
 0.75A 4qynA-2cbrA:
20.1		 4qynA-2cbrA:
35.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
ALA A  32
THR A  54
TRP A 109
LEU A 120
 None
A80  A 201 ( 4.1A)
A80  A 201 (-3.5A)
None
None
 0.65A 4qzuB-2cbrA:
20.3		 4qzuB-2cbrA:
35.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 PHE A  15
LEU A  19
ALA A  32
ILE A  52
LEU A 120
 None
None
A80  A 201 ( 4.1A)
None
None
 0.55A 5h8tA-2cbrA:
19.8		 5h8tA-2cbrA:
41.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		4 / 8 LEU A  19
ILE A  63
THR A  61
TRP A 109
 None
 0.99A 5ljbA-2cbrA:
20.2		 5ljbA-2cbrA:
41.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		4 / 7 LEU A  19
ILE A  63
THR A  61
TRP A 109
 None
 1.00A 5ljcA-2cbrA:
20.2		 5ljcA-2cbrA:
41.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2cbr PROTEIN (CRABP-I)
(Bos
taurus) 		5 / 12 LEU A  19
VAL A 127
ASP A 125
GLY A 123
LEU A  99
 None
 1.19A 5x24A-2cbrA:
undetectable		 5x24A-2cbrA:
16.49