SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 803
HIS A 801
ALA A 745
ILE A 806
 None
 0.77A 1gtnP-2cbzA:
undetectable
1gtnQ-2cbzA:
undetectable		 1gtnP-2cbzA:
16.83
1gtnQ-2cbzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 1jffB-2cbzA:
undetectable		 1jffB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 7 LEU A 661
ILE A 664
ALA A 690
ILE A 823
 None
 0.90A 1oniB-2cbzA:
undetectable
1oniC-2cbzA:
undetectable		 1oniB-2cbzA:
22.69
1oniC-2cbzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 760
THR A 759
LEU A 768
 None
 0.70A 1v8bC-2cbzA:
undetectable		 1v8bC-2cbzA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 2hxfB-2cbzA:
undetectable		 2hxfB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 2hxhB-2cbzA:
undetectable		 2hxhB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 2p4nB-2cbzA:
undetectable		 2p4nB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 2wbeB-2cbzA:
undetectable		 2wbeB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 3dcoB-2cbzA:
undetectable		 3dcoB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.02A 3edlB-2cbzA:
undetectable		 3edlB-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 837
ASP A 836
LEU A 688
LEU A 691
GLY A 671
 None
 1.03A 3iz0B-2cbzA:
undetectable		 3iz0B-2cbzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 675
VAL A 840
GLY A 678
LEU A 855
LEU A 832
 None
 0.98A 3sm2B-2cbzA:
undetectable		 3sm2B-2cbzA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A 776
LEU A 722
SER A 721
GLU A 724
 None
 0.93A 4zphA-2cbzA:
undetectable
4zphB-2cbzA:
undetectable		 4zphA-2cbzA:
20.97
4zphB-2cbzA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 663
THR A 650
GLU A 699
 None
 0.57A 6b58A-2cbzA:
undetectable		 6b58A-2cbzA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 11 VAL A 740
MET A 816
TYR A 789
LEU A 817
ALA A 779
 None
 1.49A 6dk1A-2cbzA:
0.0		 6dk1A-2cbzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 MET A 829
SER A 828
LEU A 673
ILE A 811
PRO A 794
 None
 1.26A 6dm0B-2cbzA:
undetectable
6dm0C-2cbzA:
undetectable		 6dm0B-2cbzA:
18.22
6dm0C-2cbzA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 862
LEU A 856
SER A 851
GLY A 850
ILE A 838
 None
 1.15A 6ebpB-2cbzA:
undetectable		 6ebpB-2cbzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 862
LEU A 856
SER A 851
GLY A 850
ILE A 838
 None
 1.12A 6ebpC-2cbzA:
undetectable		 6ebpC-2cbzA:
15.46