SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cc0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		3 / 3 ALA A  60
VAL A  59
GLN A  52
 None
 0.71A 3of4B-2cc0A:
undetectable		 3of4B-2cc0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 11 ARG A 111
VAL A 122
GLU A 121
ASP A 125
VAL A 151
 None
 1.10A 4d9hA-2cc0A:
undetectable		 4d9hA-2cc0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 11 ARG A 111
VAL A 122
GLU A 121
ASP A 125
VAL A 151
 None
 1.08A 4danA-2cc0A:
undetectable		 4danA-2cc0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 12 ARG A 111
VAL A 122
GLU A 121
ASP A 125
VAL A 151
 None
 1.08A 4danA-2cc0A:
undetectable
4danB-2cc0A:
undetectable		 4danA-2cc0A:
20.74
4danB-2cc0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 12 ILE A 165
LEU A  26
THR A 171
MET A 154
THR A  10
 None
 1.18A 5bykA-2cc0A:
undetectable		 5bykA-2cc0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 10 GLY A   8
GLY A 180
SER A 179
LEU A   9
LEU A  26
 None
 1.25A 5hwkA-2cc0A:
undetectable		 5hwkA-2cc0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 10 GLY A   8
GLY A 180
SER A 179
LEU A   9
LEU A  26
 None
 1.24A 5hwkB-2cc0A:
undetectable		 5hwkB-2cc0A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		6 / 12 PHE A  11
MET A 154
ILE A 165
LEU A   9
LEU A 172
VAL A 143
 None
 1.28A 5im2A-2cc0A:
undetectable		 5im2A-2cc0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 4 GLN A 170
THR A 171
THR A 161
LEU A  26
 None
 1.46A 5m5kA-2cc0A:
undetectable		 5m5kA-2cc0A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 4 GLN A 170
THR A 171
THR A 161
LEU A  26
 None
 1.48A 5m5kC-2cc0A:
2.0		 5m5kC-2cc0A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 4 GLN A 170
THR A 171
THR A 161
LEU A  26
 None
 1.46A 5m66B-2cc0A:
undetectable		 5m66B-2cc0A:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 6 ASP A  12
ASP A  13
HIS A  62
HIS A  66
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 (-2.7A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.4A)
 0.36A 5ncdA-2cc0A:
23.5
5ncdD-2cc0A:
23.9		 5ncdA-2cc0A:
31.95
5ncdD-2cc0A:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 6 ASP A  12
ASP A  13
HIS A  62
HIS A  66
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 (-2.7A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.4A)
 0.27A 5ncdB-2cc0A:
23.9
5ncdC-2cc0A:
23.6		 5ncdB-2cc0A:
31.95
5ncdC-2cc0A:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 4 ASP A  12
HIS A  62
HIS A  66
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.4A)
 0.22A 5ncdD-2cc0A:
23.9		 5ncdD-2cc0A:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		7 / 8 ASP A  12
ASP A  13
HIS A  62
HIS A  66
PRO A 102
TRP A 131
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 (-2.7A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.7A)
None
ACT  A 201 (-4.4A)
 0.56A 5nekB-2cc0A:
23.7		 5nekB-2cc0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		7 / 8 ASP A  12
ASP A  13
HIS A  62
HIS A  66
TRP A 124
TRP A 131
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 (-2.7A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
None
None
ACT  A 201 (-4.4A)
 0.72A 5nekD-2cc0A:
23.7		 5nekD-2cc0A:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 6 ASP A  12
ASP A  13
HIS A  62
HIS A  66
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 (-2.7A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.4A)
 0.38A 5nelA-2cc0A:
23.5
5nelD-2cc0A:
23.7		 5nelA-2cc0A:
31.95
5nelD-2cc0A:
31.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		5 / 6 ASP A  12
HIS A  62
HIS A  66
LEU A 153
HIS A 155
 ACT  A 201 (-3.4A)
ZN  A 200 ( 3.3A)
ZN  A 200 ( 3.3A)
None
ACT  A 201 (-4.4A)
 0.22A 5nelB-2cc0A:
23.7
5nelC-2cc0A:
23.4		 5nelB-2cc0A:
31.95
5nelC-2cc0A:
31.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		3 / 3 SER A  63
HIS A  66
TYR A 103
 None
ZN  A 200 ( 3.3A)
ACT  A 201 (-4.9A)
 1.01A 5y2tA-2cc0A:
undetectable		 5y2tA-2cc0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 5 THR A  10
ARG A 100
THR A  19
GLN A  52
 None
 1.42A 6ectA-2cc0A:
undetectable		 6ectA-2cc0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 2cc0 ACETYL-XYLAN
ESTERASE
(Streptomyces
lividans) 		4 / 4 GLN A 170
THR A 171
THR A 161
LEU A  26
 None
 1.47A 6f3mB-2cc0A:
undetectable		 6f3mB-2cc0A:
18.30