SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ccl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  54
ALA A  72
PHE A  82
PHE A 118
ILE A 104
 None
 1.03A 1cd2A-2cclA:
undetectable		 1cd2A-2cclA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A 104
ALA A 106
VAL A  21
GLY A 140
 None
 0.77A 2xrzB-2cclA:
undetectable		 2xrzB-2cclA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A  23
PHE A  27
PHE A  82
PHE A  40
 None
 0.95A 3ko0B-2cclA:
undetectable
3ko0J-2cclA:
undetectable		 3ko0B-2cclA:
20.13
3ko0J-2cclA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A  23
PHE A  27
PHE A  82
PHE A  40
 None
 0.98A 3ko0K-2cclA:
undetectable
3ko0S-2cclA:
undetectable		 3ko0K-2cclA:
20.13
3ko0S-2cclA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A  40
PHE A 136
PHE A  27
ILE A  54
PHE A  82
 None
 1.47A 3t3qA-2cclA:
undetectable		 3t3qA-2cclA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A  40
PHE A 136
PHE A  27
ILE A  54
PHE A  82
 None
 1.45A 3t3qB-2cclA:
undetectable		 3t3qB-2cclA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A  40
PHE A 136
PHE A  27
ILE A  54
PHE A  82
 None
 1.44A 3t3qC-2cclA:
undetectable		 3t3qC-2cclA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A  40
PHE A 136
PHE A  27
ILE A  54
PHE A  82
 None
 1.41A 3t3qD-2cclA:
undetectable		 3t3qD-2cclA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A  35
ILE A  59
PRO A  31
VAL A 134
 None
None
PO4  A1155 (-4.5A)
None
 0.81A 4jltA-2cclA:
undetectable		 4jltA-2cclA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2ccl CELLULOSOMAL
SCAFFOLDING PROTEIN
A
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  52
GLY A  53
ILE A  54
VAL A  13
VAL A 141
 None
 1.01A 6emuB-2cclA:
undetectable		 6emuB-2cclA:
18.75