SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cda'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 VAL A 169
VAL A 165
TRP A 172
 None
 0.97A 1av2A-2cdaA:
undetectable
1av2B-2cdaA:
undetectable		 1av2A-2cdaA:
5.26
1av2B-2cdaA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 7 PHE A 123
ALA A 149
PHE A 313
VAL A 317
VAL A 136
 None
 1.27A 1epbA-2cdaA:
undetectable		 1epbA-2cdaA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 11 ASN A 263
SER A 280
GLY A 255
GLY A 278
ASP A 252
 None
None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.4A)
None
 1.30A 1ho5A-2cdaA:
undetectable		 1ho5A-2cdaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 VAL A 169
VAL A 165
TRP A 172
 None
 0.97A 1w5uA-2cdaA:
undetectable
1w5uB-2cdaA:
undetectable		 1w5uA-2cdaA:
5.26
1w5uB-2cdaA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.88A 2avvE-2cdaA:
undetectable		 2avvE-2cdaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 213
GLY A 190
PRO A 191
 NAP  A1367 (-3.9A)
NAP  A1367 ( 4.3A)
NAP  A1367 (-3.6A)
 0.73A 2hreD-2cdaA:
undetectable		 2hreD-2cdaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.91A 2ienA-2cdaA:
undetectable		 2ienA-2cdaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.99A 2q63B-2cdaA:
undetectable		 2q63B-2cdaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 198
LEU A 195
GLY A 193
VAL A 218
THR A 228
 None
 1.32A 2q7lA-2cdaA:
undetectable		 2q7lA-2cdaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 MET A 209
THR A 228
GLU A 224
ILE A 359
LEU A 198
 None
 1.16A 2qxsA-2cdaA:
undetectable		 2qxsA-2cdaA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 162
SER A 280
ALA A 256
LEU A 261
ILE A 251
 None
None
NAP  A1367 (-3.3A)
None
None
 1.26A 2xkwB-2cdaA:
undetectable		 2xkwB-2cdaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 PRO A 215
THR A 216
ASN A 211
ILE A 359
LEU A 198
 None
None
NAP  A1367 (-3.0A)
None
None
 1.43A 3a51B-2cdaA:
undetectable		 3a51B-2cdaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 310
LYS A 137
VAL A 136
 None
 1.07A 3brfA-2cdaA:
undetectable		 3brfA-2cdaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 4 THR A 336
VAL A 350
GLY A  40
THR A  41
 None
 1.01A 3cflA-2cdaA:
undetectable		 3cflA-2cdaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.86A 3cywB-2cdaA:
undetectable		 3cywB-2cdaA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.92A 3d20B-2cdaA:
undetectable		 3d20B-2cdaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.94A 3jvyB-2cdaA:
undetectable		 3jvyB-2cdaA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_3
(HIV-1 PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.96A 3k4vD-2cdaA:
undetectable		 3k4vD-2cdaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.95A 3ndtD-2cdaA:
undetectable		 3ndtD-2cdaA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.94A 3nduD-2cdaA:
undetectable		 3nduD-2cdaA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.99A 3oxcB-2cdaA:
undetectable		 3oxcB-2cdaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A 148
LEU A 334
GLU A 358
ILE A 359
 None
 0.91A 3s56B-2cdaA:
undetectable		 3s56B-2cdaA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A  67
ASN A  89
ILE A  45
LEU A  50
GLY A  40
 ZN  A1368 (-3.1A)
None
None
None
None
 1.08A 4o1eA-2cdaA:
undetectable		 4o1eA-2cdaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 GLU A  67
ASN A  89
ILE A  45
LEU A  50
GLY A  40
 ZN  A1368 (-3.1A)
None
None
None
None
 1.10A 4o1eB-2cdaA:
undetectable		 4o1eB-2cdaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		3 / 3 GLY A  94
CYH A  99
CYH A  96
 None
ZN  A1369 (-2.3A)
ZN  A1369 (-2.4A)
 0.80A 5inzB-2cdaA:
undetectable		 5inzB-2cdaA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 ILE A 162
LEU A 276
LEU A 163
LEU A 205
LEU A 179
 None
 1.14A 5tiwA-2cdaA:
undetectable		 5tiwA-2cdaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 4 GLU A 217
THR A 216
THR A 226
LEU A 334
 None
 1.38A 5v96B-2cdaA:
11.0		 5v96B-2cdaA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 TRP A 365
THR A  33
TRP A 128
LEU A 135
 None
 1.25A 5vkqA-2cdaA:
0.9
5vkqB-2cdaA:
0.9		 5vkqA-2cdaA:
11.97
5vkqB-2cdaA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 TRP A 365
THR A  33
TRP A 128
LEU A 135
 None
 1.27A 5vkqB-2cdaA:
0.9
5vkqC-2cdaA:
0.9		 5vkqB-2cdaA:
11.97
5vkqC-2cdaA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 5 TRP A 365
THR A  33
TRP A 128
LEU A 135
 None
 1.27A 5vkqC-2cdaA:
0.9
5vkqD-2cdaA:
0.0		 5vkqC-2cdaA:
11.97
5vkqD-2cdaA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		4 / 8 GLY A 204
LEU A 205
THR A 228
VAL A 186
 None
 0.83A 6czmD-2cdaA:
undetectable
6czmF-2cdaA:
undetectable		 6czmD-2cdaA:
22.52
6czmF-2cdaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.93A 6dgxA-2cdaA:
undetectable		 6dgxA-2cdaA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2cda GLUCOSE
DEHYDROGENASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 261
GLY A 255
ALA A 256
VAL A 264
ILE A 260
 None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.3A)
None
NAP  A1367 ( 4.5A)
 0.93A 6dh6A-2cdaA:
undetectable		 6dh6A-2cdaA:
13.91