SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cdu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 7 LEU A  68
ALA A  73
VAL A  28
VAL A   5
 None
 0.85A 1epbA-2cduA:
undetectable		 1epbA-2cduA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 4 GLY A 341
SER A 339
VAL A 379
LEU A 346
 None
 1.33A 1yajB-2cduA:
undetectable		 1yajB-2cduA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 9 ILE A 224
ILE A 152
ASP A 237
ALA A 239
THR A 151
 None
 1.08A 2dtjA-2cduA:
undetectable
2dtjB-2cduA:
undetectable		 2dtjA-2cduA:
18.60
2dtjB-2cduA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 8 TYR A  62
GLY A   7
GLY A  12
THR A  13
ALA A  11
 None
FAD  A 500 (-3.2A)
None
None
FAD  A 500 (-3.5A)
 1.40A 2ej3C-2cduA:
undetectable		 2ej3C-2cduA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 8 LEU A 436
ALA A 402
GLY A 341
ILE A 409
LEU A 439
 None
 1.48A 2o4nB-2cduA:
undetectable		 2o4nB-2cduA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 8 MET A 423
LEU A 378
ILE A 387
LEU A 405
LEU A 439
 None
 1.09A 2xfhA-2cduA:
undetectable		 2xfhA-2cduA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		3 / 3 ARG A 129
GLU A 144
SER A 236
 None
 0.82A 2xkkA-2cduA:
undetectable
2xkkC-2cduA:
undetectable		 2xkkA-2cduA:
19.97
2xkkC-2cduA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 8 LEU A  48
ALA A 139
GLY A  43
LEU A  60
ASP A  56
 None
None
CSX  A  42 ( 2.6A)
None
None
 1.31A 2yfxA-2cduA:
undetectable		 2yfxA-2cduA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 5 SER A 377
LEU A 388
GLY A 341
GLU A 356
 None
 0.98A 3aiaA-2cduA:
undetectable
3aiaB-2cduA:
2.6		 3aiaA-2cduA:
18.59
3aiaB-2cduA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 7 GLY A  12
GLY A 307
THR A  19
GLU A  32
 None
None
None
FAD  A 500 (-2.6A)
 0.82A 3fpjB-2cduA:
3.8		 3fpjB-2cduA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 6 GLU A 218
ILE A 225
GLU A 233
ALA A 216
 None
 1.12A 3pgyA-2cduA:
undetectable
3pgyB-2cduA:
undetectable		 3pgyA-2cduA:
24.07
3pgyB-2cduA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 8 ALA A  11
PHE A 278
ALA A 279
THR A 266
 FAD  A 500 (-3.5A)
None
None
None
 0.87A 3t3sD-2cduA:
undetectable		 3t3sD-2cduA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 8 ALA A 280
PHE A  14
ALA A  15
THR A  19
 None
 0.99A 3t3sF-2cduA:
undetectable		 3t3sF-2cduA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 VAL A 175
GLY A 158
ILE A 154
ILE A 178
ARG A 183
 None
ADP  A 501 (-3.5A)
None
None
None
 1.02A 4iv0A-2cduA:
2.9		 4iv0A-2cduA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 VAL A 175
GLY A 158
ILE A 154
ILE A 178
ARG A 183
 None
ADP  A 501 (-3.5A)
None
None
None
 1.05A 4mwzB-2cduA:
2.8		 4mwzB-2cduA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 CYH A 242
GLY A 244
ILE A 240
GLY A 161
LEU A 164
 None
ADP  A 501 (-3.0A)
None
None
None
 1.07A 4n48A-2cduA:
2.5		 4n48A-2cduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 CYH A 242
GLY A 244
ILE A 240
GLY A 161
LEU A 164
 None
ADP  A 501 (-3.0A)
None
None
None
 1.08A 4n48B-2cduA:
undetectable		 4n48B-2cduA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 VAL A 130
LEU A 132
ILE A 224
ILE A 155
GLY A 156
 None
None
None
None
ADP  A 501 (-3.4A)
 0.97A 4y8wC-2cduA:
undetectable		 4y8wC-2cduA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		4 / 8 ALA A 280
GLY A 307
ALA A  15
GLY A  12
 None
 0.67A 4zjzA-2cduA:
undetectable		 4zjzA-2cduA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		6 / 10 ALA A 146
LEU A 142
ILE A 152
ALA A 239
ILE A 240
ILE A 224
 None
 1.31A 5mvmD-2cduA:
undetectable
5mvmE-2cduA:
undetectable		 5mvmD-2cduA:
11.82
5mvmE-2cduA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 LEU A 197
LEU A 332
ILE A 154
LEU A 208
ALA A 167
 None
 0.96A 5og9B-2cduA:
undetectable		 5og9B-2cduA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		3 / 3 SER A  41
HIS A  10
TYR A  62
 FAD  A 500 (-4.5A)
CSX  A  42 (-3.6A)
None
 0.97A 5y2tA-2cduA:
undetectable		 5y2tA-2cduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2cdu NADPH OXIDASE
(Lactobacillus
sanfranciscensis) 		5 / 12 ALA A 391
GLY A 389
GLY A 341
LEU A 375
PHE A 193
 None
 1.07A 5ybbA-2cduA:
2.7		 5ybbA-2cduA:
22.26