SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cev'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 VAL A 272
VAL A 287
ILE A 101
PRO A 274
GLY A  23
 None
 1.32A 13gsA-2cevA:
0.3		 13gsA-2cevA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 VAL A 272
VAL A 287
ILE A 101
PRO A 274
GLY A  23
 None
 1.32A 13gsB-2cevA:
0.2		 13gsB-2cevA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 4 HIS A 252
LEU A  39
LEU A  36
LEU A  95
 GAI  A1001 (-4.9A)
None
None
None
 1.20A 1a4lD-2cevA:
undetectable		 1a4lD-2cevA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.79A 1c9sI-2cevA:
undetectable
1c9sJ-2cevA:
undetectable		 1c9sI-2cevA:
14.81
1c9sJ-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.81A 1c9sU-2cevA:
undetectable
1c9sV-2cevA:
undetectable		 1c9sU-2cevA:
14.81
1c9sV-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 ARG A  18
LYS A  53
ALA A  54
ASP A  12
 None
 1.14A 1e7bA-2cevA:
0.0		 1e7bA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 ARG A  18
LYS A  53
ALA A  54
ASP A  12
 None
 0.97A 1e7cA-2cevA:
undetectable		 1e7cA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.81A 1gtnE-2cevA:
undetectable
1gtnF-2cevA:
undetectable		 1gtnE-2cevA:
14.81
1gtnF-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 GLY A 140
HIS A 139
HIS A  99
THR A 240
ALA A 123
 None
None
MN  A 301 ( 3.2A)
None
MN  A 302 ( 4.5A)
 1.41A 1gtnQ-2cevA:
undetectable
1gtnR-2cevA:
undetectable		 1gtnQ-2cevA:
14.81
1gtnR-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 GLY A 239
ALA A 123
GLY A 140
HIS A 139
HIS A  99
 None
MN  A 302 ( 4.5A)
None
None
MN  A 301 ( 3.2A)
 0.97A 1gtnL-2cevA:
undetectable
1gtnV-2cevA:
undetectable		 1gtnL-2cevA:
14.81
1gtnV-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.06A 1hxbB-2cevA:
undetectable		 1hxbB-2cevA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 HIS A 151
GLU A 131
ILE A 138
ALA A 144
ARG A  64
 None
 1.25A 1ki7A-2cevA:
undetectable		 1ki7A-2cevA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 HIS A 151
GLU A 131
ILE A 138
ALA A 144
ARG A  64
 None
 1.07A 1ki7B-2cevA:
1.8		 1ki7B-2cevA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 GLU A 271
ASN A 273
ASP A  21
ILE A  51
GLY A  14
 None
 1.17A 1q8jA-2cevA:
undetectable		 1q8jA-2cevA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 GLU A 271
ASN A 273
ASP A  21
ILE A  51
GLY A  14
 None
 1.10A 1q8jB-2cevA:
undetectable		 1q8jB-2cevA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.80A 1utdB-2cevA:
undetectable
1utdC-2cevA:
undetectable		 1utdB-2cevA:
14.81
1utdC-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLY A   8
ALA A  81
THR A 105
ILE A  49
 None
 0.80A 1utdF-2cevA:
undetectable
1utdG-2cevA:
undetectable		 1utdF-2cevA:
14.81
1utdG-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 GLY A 140
HIS A 139
HIS A  99
GLY A 239
ALA A 123
 None
None
MN  A 301 ( 3.2A)
None
MN  A 302 ( 4.5A)
 0.97A 1utdO-2cevA:
undetectable
1utdP-2cevA:
undetectable		 1utdO-2cevA:
14.81
1utdP-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 GLY A 291
SER A 292
LEU A 293
LEU A 223
HIS A 252
 None
None
None
None
GAI  A1001 (-4.9A)
 1.27A 1y7iA-2cevA:
3.8		 1y7iA-2cevA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 7 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 1.11A 2aojB-2cevA:
undetectable		 2aojB-2cevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 1.04A 2avoA-2cevA:
undetectable		 2avoA-2cevA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.10A 2avoA-2cevA:
undetectable		 2avoA-2cevA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		3 / 3 GLY A 125
GLU A 181
ASP A 122
 None
None
MN  A 302 (-2.5A)
 0.65A 2b25B-2cevA:
undetectable		 2b25B-2cevA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 11 LEU A  36
ILE A   4
SER A   5
ARG A  28
VAL A  32
 None
 0.94A 2kawA-2cevA:
undetectable		 2kawA-2cevA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.19A 2r5qA-2cevA:
undetectable		 2r5qA-2cevA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.19A 2r5qC-2cevA:
undetectable		 2r5qC-2cevA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 ILE A 211
LEU A 214
VAL A 221
GLY A 220
GLN A 262
 None
 1.06A 2wd9C-2cevA:
undetectable		 2wd9C-2cevA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 SER A 224
LEU A  95
GLY A  97
GLU A 268
 None
 1.22A 3aiaA-2cevA:
2.4
3aiaB-2cevA:
2.4		 3aiaA-2cevA:
22.97
3aiaB-2cevA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		3 / 3 TRP A 120
VAL A  82
ARG A  90
 None
 0.75A 3b0wA-2cevA:
undetectable		 3b0wA-2cevA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 HIS A 139
ASP A 126
HIS A 124
ASP A 122
 None
MN  A 301 ( 2.6A)
MN  A 302 ( 3.2A)
MN  A 302 (-2.5A)
 1.24A 3c0zA-2cevA:
12.8		 3c0zA-2cevA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.03A 3d1yB-2cevA:
undetectable		 3d1yB-2cevA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 0.99A 3ekqB-2cevA:
undetectable		 3ekqB-2cevA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 ILE A 243
GLY A 244
GLY A 245
LEU A 246
VAL A 238
 None
 0.97A 3em4V-2cevA:
undetectable		 3em4V-2cevA:
18.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		9 / 9 HIS A 124
ASP A 126
ASN A 128
SER A 135
HIS A 139
GLY A 140
ASP A 178
GLU A 181
THR A 240
 MN  A 302 ( 3.2A)
MN  A 301 ( 2.6A)
None
None
None
None
None
None
None
 0.37A 3gn0A-2cevA:
45.4		 3gn0A-2cevA:
41.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		9 / 9 HIS A 124
ASP A 126
ASN A 128
SER A 135
HIS A 139
GLY A 140
ASP A 178
GLU A 181
THR A 240
 MN  A 302 ( 3.2A)
MN  A 301 ( 2.6A)
None
None
None
None
None
None
None
 0.32A 3gn0B-2cevA:
45.7		 3gn0B-2cevA:
41.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.05A 3k4vC-2cevA:
undetectable		 3k4vC-2cevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A 293
TYR A 113
ALA A 102
VAL A 118
GLY A 117
 None
 1.05A 3ln1C-2cevA:
undetectable		 3ln1C-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 ALA A 110
VAL A 118
GLY A 104
ILE A 157
ILE A 164
 None
 0.99A 3nujA-2cevA:
undetectable		 3nujA-2cevA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 ILE A 185
PHE A 184
LEU A 171
ALA A 102
LEU A 106
 None
 0.92A 3ozuA-2cevA:
4.0		 3ozuA-2cevA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 THR A 129
ASN A 128
GLY A 140
ILE A 103
 None
 1.03A 3w9tF-2cevA:
undetectable		 3w9tF-2cevA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.16A 4cevA-2cevA:
57.7
4cevB-2cevA:
57.8		 4cevA-2cevA:
100.00
4cevB-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.17A 4cevA-2cevA:
57.7
4cevC-2cevA:
58.0		 4cevA-2cevA:
100.00
4cevC-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.19A 4cevD-2cevA:
58.0
4cevE-2cevA:
58.0		 4cevD-2cevA:
100.00
4cevE-2cevA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ARG A 249
HIS A 252
GLU A 256
LEU A 298
 None
GAI  A1001 (-4.9A)
GAI  A1001 (-2.9A)
GAI  A1001 (-4.5A)
 0.19A 4cevE-2cevA:
58.0
4cevF-2cevA:
58.1		 4cevE-2cevA:
100.00
4cevF-2cevA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 0.93A 4dqbA-2cevA:
undetectable		 4dqbA-2cevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 11 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 0.98A 4dqeA-2cevA:
undetectable		 4dqeA-2cevA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 11 LEU A  36
GLY A  47
ILE A   7
VAL A  32
ILE A  33
 None
 0.96A 4dqhA-2cevA:
undetectable		 4dqhA-2cevA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 7 ARG A  88
PRO A  24
SER A  25
VAL A  94
 None
 1.18A 4klrA-2cevA:
3.1		 4klrA-2cevA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 ASP A 226
PRO A 274
ALA A 283
GLY A 239
GLY A  23
 MN  A 302 (-2.9A)
None
None
None
None
 1.25A 4mm5A-2cevA:
undetectable		 4mm5A-2cevA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 ASP A 226
PRO A 274
ALA A 283
GLY A 239
GLY A  23
 MN  A 302 (-2.9A)
None
None
None
None
 1.33A 4mmbA-2cevA:
undetectable		 4mmbA-2cevA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 ASP A 226
PRO A 274
ALA A 283
GLY A 239
GLY A  23
 MN  A 302 (-2.9A)
None
None
None
None
 1.26A 4mmdA-2cevA:
undetectable		 4mmdA-2cevA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 ALA A 110
VAL A 118
GLY A 104
ILE A 157
ILE A 164
 None
 1.12A 4q1wB-2cevA:
undetectable		 4q1wB-2cevA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		3 / 3 ASP A 122
ASP A 126
ASN A 137
 MN  A 302 (-2.5A)
MN  A 301 ( 2.6A)
None
 0.74A 4q5mA-2cevA:
undetectable		 4q5mA-2cevA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 LEU A 225
VAL A  94
LEU A  93
GLY A 291
 None
 0.89A 4r3aA-2cevA:
undetectable		 4r3aA-2cevA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 ARG A  28
GLY A   8
GLY A  96
PRO A  24
 None
 0.93A 4u9uA-2cevA:
4.0		 4u9uA-2cevA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 ARG A  28
GLY A   8
GLY A  96
PRO A  24
 None
 0.95A 4u9uB-2cevA:
4.0		 4u9uB-2cevA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 LEU A  36
GLU A  34
MET A  27
LEU A  95
 None
 1.19A 4xi3B-2cevA:
undetectable		 4xi3B-2cevA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 LEU A  65
LEU A  68
GLY A  61
ALA A 145
ILE A 138
 None
 1.16A 4xj7C-2cevA:
undetectable
4xj7D-2cevA:
undetectable		 4xj7C-2cevA:
24.30
4xj7D-2cevA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 GLY A 108
VAL A 109
VAL A  82
HIS A 222
SER A 266
 None
 1.08A 4yb6A-2cevA:
undetectable
4yb6E-2cevA:
undetectable		 4yb6A-2cevA:
25.84
4yb6E-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 GLY A 108
VAL A 109
VAL A  82
HIS A 222
SER A 266
 None
 1.07A 4yb6B-2cevA:
undetectable
4yb6C-2cevA:
undetectable		 4yb6B-2cevA:
25.84
4yb6C-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 GLY A 108
VAL A 109
VAL A  82
HIS A 222
SER A 266
 None
 1.18A 4yb6C-2cevA:
undetectable
4yb6F-2cevA:
undetectable		 4yb6C-2cevA:
25.84
4yb6F-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 HIS A 222
SER A 266
GLY A 108
VAL A 109
VAL A  82
 None
 1.18A 4yb6A-2cevA:
undetectable
4yb6D-2cevA:
undetectable		 4yb6A-2cevA:
25.84
4yb6D-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 HIS A 222
SER A 266
GLY A 108
VAL A 109
VAL A  82
 None
 1.19A 4yb6D-2cevA:
undetectable
4yb6E-2cevA:
undetectable		 4yb6D-2cevA:
25.84
4yb6E-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 10 HIS A 222
SER A 266
GLY A 108
VAL A 109
VAL A  82
 None
 1.07A 4yb6B-2cevA:
undetectable
4yb6F-2cevA:
undetectable		 4yb6B-2cevA:
25.84
4yb6F-2cevA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 5 ILE A  33
ILE A   4
ARG A  90
GLU A  44
 None
 1.28A 4zzcE-2cevA:
undetectable		 4zzcE-2cevA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 6 ALA A 123
SER A 176
ASP A 231
PRO A 232
 MN  A 302 ( 4.5A)
None
None
None
 0.79A 5c6pA-2cevA:
undetectable		 5c6pA-2cevA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 ASP A 277
HIS A 139
ASP A 126
HIS A 124
ASP A 122
 None
None
MN  A 301 ( 2.6A)
MN  A 302 ( 3.2A)
MN  A 302 (-2.5A)
 1.26A 5ef8A-2cevA:
5.2		 5ef8A-2cevA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 ASP A 277
HIS A 139
ASP A 126
HIS A 124
ASP A 122
 None
None
MN  A 301 ( 2.6A)
MN  A 302 ( 3.2A)
MN  A 302 (-2.5A)
 1.25A 5ef8B-2cevA:
4.5		 5ef8B-2cevA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLU A 250
GLY A 245
GLY A 244
VAL A 198
 None
 0.80A 5f8yA-2cevA:
undetectable		 5f8yA-2cevA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 8 GLU A 250
GLY A 245
GLY A 244
VAL A 198
 None
 0.79A 5f8yB-2cevA:
undetectable		 5f8yB-2cevA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		3 / 3 ILE A 275
MET A  27
ASP A  21
 None
 0.68A 5h2uA-2cevA:
undetectable		 5h2uA-2cevA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 0.99A 5kqxB-2cevA:
undetectable		 5kqxB-2cevA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 LEU A  46
ILE A 101
GLY A 104
PRO A  92
ILE A   7
 None
 1.08A 5kr2D-2cevA:
undetectable		 5kr2D-2cevA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A  46
VAL A  94
GLY A 108
SER A   5
ILE A   7
 None
 0.79A 5t2zB-2cevA:
undetectable		 5t2zB-2cevA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		4 / 7 THR A 218
LEU A 214
ILE A 211
THR A 210
 None
 0.90A 5zsfA-2cevA:
undetectable
5zsfB-2cevA:
undetectable		 5zsfA-2cevA:
13.54
5zsfB-2cevA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 LEU A 276
ILE A 275
VAL A 174
GLY A  23
ARG A  17
 None
 1.25A 6a7pA-2cevA:
undetectable		 6a7pA-2cevA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 9 VAL A 198
HIS A 196
ASP A 199
LEU A 230
SER A 233
 None
None
GAI  A1003 (-3.8A)
None
None
 1.43A 6c2mD-2cevA:
undetectable		 6c2mD-2cevA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2cev PROTEIN (ARGINASE)
([Bacillus]
caldovelox) 		5 / 12 THR A 105
GLY A 104
VAL A  71
GLY A 117
HIS A  99
 None
None
None
None
MN  A 301 ( 3.2A)
 1.08A 6gngA-2cevA:
2.6		 6gngA-2cevA:
19.44