SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		4 / 8 VAL A  86
ALA A  96
PHE A 102
GLU A 302
 None
 1.07A 1dmiA-2cexA:
undetectable
1dmiB-2cexA:
undetectable		 1dmiA-2cexA:
19.40
1dmiB-2cexA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		4 / 7 LEU A   5
PHE A  63
LEU A 226
PHE A  24
 None
 0.97A 1wrlE-2cexA:
undetectable
1wrlF-2cexA:
undetectable		 1wrlE-2cexA:
15.26
1wrlF-2cexA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		4 / 5 LEU A 226
PRO A 227
LEU A 230
ILE A  36
 None
 0.73A 2qd4A-2cexA:
undetectable		 2qd4A-2cexA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 8 ALA A 158
MET A 141
GLY A 143
LEU A 144
GLY A 184
 None
 1.30A 2yfxA-2cexA:
undetectable		 2yfxA-2cexA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 9 ALA A  93
ASP A 213
LEU A 215
ILE A 107
PHE A  98
 None
 1.17A 3freX-2cexA:
undetectable		 3freX-2cexA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 12 VAL A 218
LEU A  61
ILE A  36
ILE A  38
LEU A  40
 None
 1.34A 3w67D-2cexA:
undetectable		 3w67D-2cexA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		4 / 4 LEU A 226
PRO A 227
LEU A 230
ILE A  36
 None
 0.81A 4f4dB-2cexA:
undetectable		 4f4dB-2cexA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 12 ALA A  78
LYS A 109
LEU A  53
LEU A  56
GLY A  59
 None
 1.15A 4l9qB-2cexA:
undetectable		 4l9qB-2cexA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 9 VAL A  80
ALA A  79
GLY A 103
PHE A 102
SER A  68
 None
 1.23A 4mmeB-2cexA:
1.2		 4mmeB-2cexA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		4 / 5 TYR A 123
GLU A 253
LEU A 211
GLN A 128
 None
 1.32A 4qztB-2cexA:
undetectable		 4qztB-2cexA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 12 GLU A 253
ILE A 210
ASN A 212
HIS A 209
TYR A  85
 None
 1.38A 4s0vA-2cexA:
undetectable		 4s0vA-2cexA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 12 ALA A  82
GLY A 125
ALA A  79
PRO A  84
TYR A 282
 None
 1.21A 5zvgA-2cexA:
undetectable		 5zvgA-2cexA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2cex PROTEIN HI0146
(Haemophilus
influenzae) 		5 / 12 ALA A  82
GLY A 125
ALA A  79
PRO A  84
TYR A 282
 None
 1.19A 5zvgB-2cexA:
undetectable		 5zvgB-2cexA:
22.83