SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 ILE B 209
PHE B 206
VAL B   8
MET B  62
 None
 1.15A 1kb9A-2cfaB:
undetectable
1kb9C-2cfaB:
undetectable
1kb9D-2cfaB:
undetectable
1kb9E-2cfaB:
undetectable		 1kb9A-2cfaB:
20.37
1kb9C-2cfaB:
17.66
1kb9D-2cfaB:
21.29
1kb9E-2cfaB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 10 LYS B  98
GLU B  20
ILE B 209
GLU B 205
ILE B 172
 None
 1.33A 2j9dD-2cfaB:
0.1
2j9dE-2cfaB:
0.1
2j9dF-2cfaB:
0.0		 2j9dD-2cfaB:
21.56
2j9dE-2cfaB:
21.56
2j9dF-2cfaB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 LEU B  44
ASN B  38
ARG B  28
 CME  B  48 ( 4.7A)
None
None
 0.84A 2qhfA-2cfaB:
undetectable		 2qhfA-2cfaB:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 5 LEU B 213
ARG B 173
ILE B  56
PHE B  57
 None
FAD  B1217 ( 3.9A)
None
None
 1.14A 3ln1D-2cfaB:
0.0		 3ln1D-2cfaB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 8 SER B  81
CYH B 198
PHE B 202
LEU B 194
 FAD  B1217 (-2.6A)
None
None
None
 1.04A 3m0wE-2cfaB:
undetectable
3m0wF-2cfaB:
undetectable
3m0wG-2cfaB:
undetectable
3m0wH-2cfaB:
undetectable		 3m0wE-2cfaB:
18.04
3m0wF-2cfaB:
18.04
3m0wG-2cfaB:
18.04
3m0wH-2cfaB:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2cfa THYMIDYLATE SYNTHASE
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 7 ILE B 209
MET B  62
ALA B  60
ILE B  23
 None
 0.78A 4y03A-2cfaB:
undetectable		 4y03A-2cfaB:
18.78