SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 LEU A 378
TYR A  41
ILE A 376
GLY A 320
 None
 0.86A 2du8A-2cfbA:
undetectable		 2du8A-2cfbA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.48A 2pxcA-2cfbA:
undetectable		 2pxcA-2cfbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 LEU A  61
PRO A  47
VAL A  50
GLY A  51
 None
 1.07A 2qd5A-2cfbA:
undetectable		 2qd5A-2cfbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 5 ARG A 230
PRO A  47
GLY A  46
TRP A  45
 None
 1.38A 2y7kB-2cfbA:
undetectable		 2y7kB-2cfbA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 4 ILE A 397
ARG A 326
ILE A 401
THR A 388
 None
 0.98A 3ia4C-2cfbA:
undetectable		 3ia4C-2cfbA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.40A 3p97A-2cfbA:
undetectable		 3p97A-2cfbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 GLU A 207
PHE A 240
LYS A 239
VAL A 192
TYR A 167
 None
 0.94A 3s3vA-2cfbA:
undetectable		 3s3vA-2cfbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 4 GLY A 254
GLY A 294
THR A 292
LEU A  61
 None
 0.83A 3si7C-2cfbA:
undetectable
3si7D-2cfbA:
undetectable		 3si7C-2cfbA:
22.48
3si7D-2cfbA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 10 ALA A 404
LEU A 408
LEU A 411
HIS A 368
LEU A 378
 None
 1.43A 3uudB-2cfbA:
undetectable		 3uudB-2cfbA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 THR A 248
GLN A 237
PHE A 229
GLY A 235
ALA A  82
 None
 1.22A 3v3oA-2cfbA:
undetectable		 3v3oA-2cfbA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.40A 4ctjA-2cfbA:
undetectable		 4ctjA-2cfbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 GLY A  46
GLY A 256
LEU A 257
VAL A 259
 None
 0.87A 4fgzA-2cfbA:
undetectable		 4fgzA-2cfbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 GLY A  46
GLY A 256
LEU A 257
VAL A 259
 None
 0.87A 4fgzB-2cfbA:
undetectable		 4fgzB-2cfbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 GLY A 342
GLY A 386
LEU A 378
PHE A 345
VAL A 318
 None
 1.05A 4fr0A-2cfbA:
undetectable		 4fr0A-2cfbA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 10 ALA A 404
LEU A 408
LEU A 411
HIS A 368
LEU A 378
 None
 1.43A 5dxeB-2cfbA:
undetectable		 5dxeB-2cfbA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.40A 5e9qA-2cfbA:
undetectable		 5e9qA-2cfbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.43A 5ec8C-2cfbA:
undetectable		 5ec8C-2cfbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.40A 5eifA-2cfbA:
undetectable		 5eifA-2cfbA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 VAL A 108
GLY A 263
ARG A 265
VAL A 242
LEU A 220
 None
 1.19A 5ergB-2cfbA:
undetectable		 5ergB-2cfbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.45A 5njvA-2cfbA:
undetectable		 5njvA-2cfbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 7 GLY A 260
GLY A 101
LEU A 257
ALA A 290
 None
PLR  A1412 (-3.3A)
None
None
 0.75A 5o96C-2cfbA:
undetectable		 5o96C-2cfbA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 6 ARG A 110
ARG A 113
ALA A 114
PRO A 277
 None
 1.24A 5odqA-2cfbA:
undetectable		 5odqA-2cfbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		6 / 12 GLY A 260
GLY A 294
GLY A 255
GLY A 250
THR A 297
ILE A 295
 None
 1.42A 5wz2B-2cfbA:
undetectable		 5wz2B-2cfbA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		5 / 12 ALA A 261
VAL A  85
MET A  84
GLY A 294
ALA A 293
 None
 1.25A 5x23A-2cfbA:
undetectable		 5x23A-2cfbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		4 / 8 LEU A 257
VAL A  57
LEU A  61
ILE A  58
 None
 0.79A 6cb4A-2cfbA:
undetectable		 6cb4A-2cfbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
(Synechococcus
elongatus) 		3 / 3 HIS A  54
ARG A 303
ILE A 300
 None
 0.74A 6fgdA-2cfbA:
undetectable		 6fgdA-2cfbA:
23.79