SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		4 / 7 SER C 137
GLY C 128
GLY C 129
ILE C  68
 None
 0.72A 4yjiA-2cfhC:
undetectable		 4yjiA-2cfhC:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		4 / 7 ASN C  38
LYS C  35
TYR C 118
LEU C 119
 None
 1.10A 4yv5A-2cfhC:
undetectable		 4yv5A-2cfhC:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		4 / 4 CYH C 149
LEU C 102
LEU C 119
ALA C 115
 None
 1.01A 5hpuA-2cfhC:
undetectable
5hpuB-2cfhC:
undetectable		 5hpuA-2cfhC:
12.96
5hpuB-2cfhC:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		6 / 12 LEU C  47
GLY C 128
GLY C  44
SER C 137
LEU C 133
ILE C 135
 None
 1.42A 6ectA-2cfhC:
undetectable		 6ectA-2cfhC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		6 / 12 LEU C  47
GLY C 128
GLY C  44
SER C 137
LEU C 133
ILE C 135
 None
 1.44A 6ecxA-2cfhC:
undetectable		 6ecxA-2cfhC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cfh TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6B
(Homo
sapiens) 		3 / 3 LEU C  36
GLY C  40
PHE C  77
 CSO  C  32 ( 3.8A)
None
None
 0.59A 6exiC-2cfhC:
undetectable		 6exiC-2cfhC:
20.13