SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
ALA A 151
LEU A 111
VAL A 123
LEU A  65
 None
 1.03A 1fm6U-2cfmA:
undetectable		 1fm6U-2cfmA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 158
GLY A 160
THR A 161
GLU A  48
GLY A  47
 None
 1.24A 1i7qA-2cfmA:
undetectable		 1i7qA-2cfmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 158
GLY A 160
THR A 161
GLU A  48
GLY A  47
 None
 1.28A 1i7qC-2cfmA:
undetectable		 1i7qC-2cfmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 386
LYS A 381
VAL A 382
 None
 0.82A 1l2iA-2cfmA:
undetectable		 1l2iA-2cfmA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 GLU A 168
GLU A 187
THR A 541
TYR A 454
 None
 0.92A 1qvtA-2cfmA:
undetectable		 1qvtA-2cfmA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 429
PHE A 312
ARG A 269
ALA A 529
 None
None
AMP  A1563 (-3.4A)
None
 1.17A 1rqpC-2cfmA:
undetectable		 1rqpC-2cfmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 429
PHE A 312
ARG A 269
ALA A 529
 None
None
AMP  A1563 (-3.4A)
None
 1.14A 1rqpA-2cfmA:
undetectable		 1rqpA-2cfmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 8 ASP A 429
ILE A 503
ILE A 432
GLY A 452
PRO A 525
 None
 1.41A 1sh9A-2cfmA:
undetectable		 1sh9A-2cfmA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 1.00A 1v55P-2cfmA:
undetectable
1v55W-2cfmA:
undetectable		 1v55P-2cfmA:
17.30
1v55W-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
ALA A 151
LEU A 111
VAL A 123
LEU A  65
 None
 1.02A 1xdkE-2cfmA:
undetectable		 1xdkE-2cfmA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		3 / 3 LEU A  20
LEU A  25
MET A 177
 None
 0.81A 1ya3B-2cfmA:
undetectable		 1ya3B-2cfmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		6 / 12 VAL A  33
LEU A  30
VAL A  26
THR A 164
VAL A 166
LEU A 154
 None
 1.34A 2cbrA-2cfmA:
undetectable		 2cbrA-2cfmA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 1.01A 2dysC-2cfmA:
undetectable
2dysJ-2cfmA:
undetectable		 2dysC-2cfmA:
17.30
2dysJ-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 319
ARG A 320
ASP A 533
ASP A 532
 None
 1.22A 2e5dA-2cfmA:
undetectable
2e5dB-2cfmA:
undetectable		 2e5dA-2cfmA:
22.47
2e5dB-2cfmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 ASP A 532
PHE A 319
ARG A 320
ASP A 533
 None
 1.21A 2e5dA-2cfmA:
undetectable
2e5dB-2cfmA:
undetectable		 2e5dA-2cfmA:
22.47
2e5dB-2cfmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.96A 2eijP-2cfmA:
undetectable
2eijW-2cfmA:
undetectable		 2eijP-2cfmA:
17.30
2eijW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.96A 2eilP-2cfmA:
undetectable
2eilW-2cfmA:
undetectable		 2eilP-2cfmA:
17.30
2eilW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.96A 2einP-2cfmA:
undetectable
2einW-2cfmA:
undetectable		 2einP-2cfmA:
17.30
2einW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 ILE A  45
PRO A  42
PHE A  40
VAL A  33
 None
 1.23A 2hjhB-2cfmA:
undetectable		 2hjhB-2cfmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 GLN A  11
ALA A   7
GLY A  91
LEU A  90
LEU A 149
 None
 1.04A 2nv4A-2cfmA:
undetectable		 2nv4A-2cfmA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 GLN A  11
ALA A   7
GLY A  91
LEU A  90
LEU A 149
 None
 1.05A 2nv4B-2cfmA:
undetectable		 2nv4B-2cfmA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 300
ALA A 253
LEU A 316
MET A 328
 None
 1.09A 2oaxA-2cfmA:
undetectable		 2oaxA-2cfmA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 146
THR A  73
VAL A  69
SER A 108
PRO A 148
 None
 1.14A 2okcA-2cfmA:
undetectable		 2okcA-2cfmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 429
PHE A 312
ARG A 269
ALA A 529
 None
None
AMP  A1563 (-3.4A)
None
 1.18A 2v7uA-2cfmA:
undetectable		 2v7uA-2cfmA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 PHE A 471
LEU A 451
ALA A 435
LEU A 483
 None
 0.99A 2vcvK-2cfmA:
undetectable		 2vcvK-2cfmA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 GLU A 297
TYR A 409
LYS A 249
PHE A 339
 None
None
AMP  A1563 (-3.5A)
AMP  A1563 (-3.3A)
 1.34A 2vmyA-2cfmA:
undetectable		 2vmyA-2cfmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 GLU A 150
ILE A 113
GLN A 118
ALA A 124
 None
 0.75A 2xkwA-2cfmA:
undetectable		 2xkwA-2cfmA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.93A 2zxwC-2cfmA:
undetectable
2zxwJ-2cfmA:
undetectable		 2zxwC-2cfmA:
17.30
2zxwJ-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.89A 2zxwP-2cfmA:
undetectable
2zxwW-2cfmA:
undetectable		 2zxwP-2cfmA:
17.30
2zxwW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.98A 3ag1C-2cfmA:
undetectable
3ag1J-2cfmA:
undetectable		 3ag1C-2cfmA:
17.30
3ag1J-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.92A 3asoC-2cfmA:
undetectable
3asoJ-2cfmA:
undetectable		 3asoC-2cfmA:
17.30
3asoJ-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 4 ILE A 264
GLN A 256
ILE A 371
LEU A 271
 None
 1.13A 3dzyD-2cfmA:
undetectable		 3dzyD-2cfmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 TYR A   3
GLY A  47
GLU A  48
GLU A  57
 None
 0.76A 3fpjA-2cfmA:
undetectable		 3fpjA-2cfmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 200
PHE A 179
LEU A 171
ALA A 178
 None
 0.85A 3hrdA-2cfmA:
undetectable
3hrdB-2cfmA:
undetectable		 3hrdA-2cfmA:
23.49
3hrdB-2cfmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 267
GLU A  55
LEU A 271
LYS A 223
 None
 1.43A 3k8mB-2cfmA:
undetectable		 3k8mB-2cfmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		7 / 12 GLU A 247
LYS A 249
ARG A 269
GLU A 299
PHE A 339
LYS A 403
LYS A 420
 AMP  A1563 (-4.0A)
AMP  A1563 (-3.5A)
AMP  A1563 (-3.4A)
AMP  A1563 ( 3.0A)
AMP  A1563 (-3.3A)
AMP  A1563 (-2.8A)
AMP  A1563 (-2.8A)
 0.81A 3qwuA-2cfmA:
10.6		 3qwuA-2cfmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		6 / 11 GLU A 247
LYS A 249
ARG A 269
GLU A 299
PHE A 339
LYS A 403
 AMP  A1563 (-4.0A)
AMP  A1563 (-3.5A)
AMP  A1563 (-3.4A)
AMP  A1563 ( 3.0A)
AMP  A1563 (-3.3A)
AMP  A1563 (-2.8A)
 0.67A 3qwuB-2cfmA:
11.5		 3qwuB-2cfmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		6 / 12 LEU A 336
GLY A 252
ALA A 253
ASP A 533
ILE A 332
ILE A 281
 None
 1.48A 3s54B-2cfmA:
undetectable		 3s54B-2cfmA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG8_A_TOYA305_1
(APH(2'')-ID)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 429
ASP A 533
ASP A 540
GLU A 398
GLU A 299
 None
None
None
MG  A1562 ( 3.9A)
AMP  A1563 ( 3.0A)
 1.16A 3sg8A-2cfmA:
0.8		 3sg8A-2cfmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 429
ASP A 533
ASP A 540
GLU A 299
LYS A 422
 None
None
None
AMP  A1563 ( 3.0A)
None
 1.49A 4dfuA-2cfmA:
0.0		 4dfuA-2cfmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 412
VAL A 408
GLU A 410
TYR A 409
 None
 0.91A 4fgzB-2cfmA:
undetectable		 4fgzB-2cfmA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 151
TYR A   3
TYR A 153
GLY A 160
GLY A  91
 None
 1.29A 4mm9A-2cfmA:
undetectable		 4mm9A-2cfmA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 540
ASP A 429
GLU A 504
ARG A 269
 None
None
None
AMP  A1563 (-3.4A)
 1.38A 4ntxA-2cfmA:
undetectable
4ntxC-2cfmA:
1.5		 4ntxA-2cfmA:
21.68
4ntxC-2cfmA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 GLU A 543
ASP A 540
GLU A 426
ARG A 269
 None
None
AMP  A1563 ( 3.9A)
AMP  A1563 (-3.4A)
 1.09A 4ntxA-2cfmA:
undetectable
4ntxC-2cfmA:
1.5		 4ntxA-2cfmA:
21.68
4ntxC-2cfmA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 9 VAL A  98
ILE A 113
VAL A 116
THR A 157
ALA A 151
 None
 1.31A 4oqrA-2cfmA:
undetectable		 4oqrA-2cfmA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 SER A 469
GLY A 470
ARG A 526
PHE A 524
 None
 1.32A 4r82A-2cfmA:
undetectable
4r82B-2cfmA:
undetectable		 4r82A-2cfmA:
16.27
4r82B-2cfmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 7 LEU A  46
ALA A 174
LEU A 170
ILE A 175
 None
 0.80A 4ubsA-2cfmA:
undetectable		 4ubsA-2cfmA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 6 LEU A  44
ILE A  45
LEU A   6
TYR A   3
 None
 0.94A 4w5nA-2cfmA:
undetectable		 4w5nA-2cfmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 4 GLY A 169
LEU A  30
PHE A  29
ILE A  45
 None
 0.81A 4xv2A-2cfmA:
undetectable		 4xv2A-2cfmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		3 / 3 PHE A  29
ILE A  45
ASP A 173
 None
 0.72A 5cswA-2cfmA:
undetectable		 5cswA-2cfmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		3 / 3 PHE A  29
ILE A  45
ASP A 173
 None
 0.64A 5cswB-2cfmA:
undetectable		 5cswB-2cfmA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 154
GLY A  91
LEU A 142
VAL A  69
ALA A 146
 None
 0.95A 5o96A-2cfmA:
undetectable
5o96B-2cfmA:
undetectable		 5o96A-2cfmA:
18.21
5o96B-2cfmA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_A_OQRA302_0
(SULFOTRANSFERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 9 LEU A   6
VAL A  33
LEU A  30
ASP A  36
PHE A  40
 None
 1.50A 5tixA-2cfmA:
0.0		 5tixA-2cfmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 4 GLY A 535
PRO A 536
VAL A 502
ARG A 270
 None
 0.88A 5uunA-2cfmA:
0.0
5uunB-2cfmA:
0.0		 5uunA-2cfmA:
18.60
5uunB-2cfmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 429
PRO A 456
GLU A 543
THR A 541
 None
 1.08A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 538
GLU A 543
ARG A 544
THR A 541
 None
 1.37A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		4 / 5 PRO A 456
GLU A 543
ARG A 544
THR A 541
 None
 1.47A 5uxcA-2cfmA:
undetectable		 5uxcA-2cfmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 2cfm THERMOSTABLE DNA
LIGASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 429
GLU A 504
ASP A 251
LEU A 393
ILE A 421
 None
 1.28A 6fzbB-2cfmA:
undetectable		 6fzbB-2cfmA:
8.73