SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 11 MET A 176
PHE A 147
ALA A  85
LEU A  89
ALA A  95
 None
 1.16A 1jb0B-2cfoA:
undetectable		 1jb0B-2cfoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 12 GLY A  93
ARG A 153
LEU A 223
GLU A 226
ALA A 227
 None
 0.95A 1mjqC-2cfoA:
1.6
1mjqD-2cfoA:
undetectable		 1mjqC-2cfoA:
11.09
1mjqD-2cfoA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 12 GLY A  93
ARG A 153
LEU A 223
GLU A 226
ALA A 227
 None
 0.95A 1mjqI-2cfoA:
1.6
1mjqJ-2cfoA:
undetectable		 1mjqI-2cfoA:
11.09
1mjqJ-2cfoA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		3 / 3 PHE A 381
LEU A 359
LEU A 363
 None
 0.58A 1mx1E-2cfoA:
2.3		 1mx1E-2cfoA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 5 ASP A 470
LEU A 457
ALA A 447
LEU A 474
 None
 1.05A 1nh8A-2cfoA:
0.6		 1nh8A-2cfoA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 6 ASN A 123
ARG A 120
ILE A 149
GLY A 174
 None
 1.06A 1oniD-2cfoA:
undetectable
1oniF-2cfoA:
undetectable		 1oniD-2cfoA:
15.05
1oniF-2cfoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.87A 1v55N-2cfoA:
undetectable
1v55W-2cfoA:
undetectable		 1v55N-2cfoA:
21.24
1v55W-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.91A 2einA-2cfoA:
2.9
2einJ-2cfoA:
undetectable		 2einA-2cfoA:
21.24
2einJ-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 5 ALA A 447
ALA A 429
ALA A 433
GLN A 394
 None
 0.91A 2nyrB-2cfoA:
undetectable		 2nyrB-2cfoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 5 LEU A 294
ALA A 296
TRP A  27
LEU A  28
 None
 1.25A 2oaxA-2cfoA:
undetectable		 2oaxA-2cfoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 7 ALA A 268
ALA A 272
THR A 276
LEU A  28
 None
 0.87A 2wx2A-2cfoA:
undetectable		 2wx2A-2cfoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 ALA A 268
ALA A 272
THR A 276
LEU A  28
 None
 0.97A 2wx2B-2cfoA:
undetectable		 2wx2B-2cfoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  15
LEU A 271
LEU A  66
ARG A 262
 None
 1.02A 2xn3A-2cfoA:
undetectable
2xn3B-2cfoA:
0.0		 2xn3A-2cfoA:
21.40
2xn3B-2cfoA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		3 / 3 TYR A 192
GLU A  42
THR A  19
 GLU  A1486 (-4.9A)
GLU  A1486 ( 4.9A)
None
 0.86A 2y7hB-2cfoA:
undetectable		 2y7hB-2cfoA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 THR A  54
LEU A  39
ASP A 199
SER A  10
 None
 1.00A 2zw9A-2cfoA:
undetectable		 2zw9A-2cfoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.90A 3abkA-2cfoA:
undetectable
3abkJ-2cfoA:
undetectable		 3abkA-2cfoA:
21.24
3abkJ-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.80A 3ablN-2cfoA:
undetectable
3ablW-2cfoA:
undetectable		 3ablN-2cfoA:
21.24
3ablW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.88A 3abmN-2cfoA:
undetectable
3abmW-2cfoA:
undetectable		 3abmN-2cfoA:
21.24
3abmW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.85A 3asoN-2cfoA:
undetectable
3asoW-2cfoA:
undetectable		 3asoN-2cfoA:
21.24
3asoW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 ALA A 268
ALA A 272
THR A 276
LEU A  28
 None
 0.95A 3l4dA-2cfoA:
undetectable		 3l4dA-2cfoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 ALA A 268
ALA A 272
THR A 276
LEU A  28
 None
 0.94A 3l4dD-2cfoA:
undetectable		 3l4dD-2cfoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 11 MET A 176
PHE A 147
ALA A  85
LEU A  89
ALA A  95
 None
 1.16A 3pcqB-2cfoA:
0.0		 3pcqB-2cfoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 ILE A 304
TRP A 280
ILE A 209
PHE A 299
 None
 0.88A 3uqbA-2cfoA:
undetectable		 3uqbA-2cfoA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 GLY A  35
THR A   2
MET A 203
GLY A 204
 None
 0.87A 4fo4B-2cfoA:
undetectable		 4fo4B-2cfoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		3 / 3 ILE A 209
ASP A 159
ARG A  21
 None
 0.84A 4pstA-2cfoA:
undetectable		 4pstA-2cfoA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 6 LEU A 464
LEU A 359
PHE A 380
PHE A 381
 None
 1.09A 4y4dA-2cfoA:
undetectable		 4y4dA-2cfoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 12 PHE A 136
TYR A 121
LEU A 105
HIS A 125
LEU A 128
 None
 1.37A 5ji0D-2cfoA:
0.0		 5ji0D-2cfoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 12 PHE A 136
TYR A 121
LEU A 105
HIS A 125
LEU A 128
 None
 1.48A 5ycpA-2cfoA:
0.0		 5ycpA-2cfoA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		4 / 8 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.92A 5zcpN-2cfoA:
undetectable
5zcpW-2cfoA:
undetectable		 5zcpN-2cfoA:
21.24
5zcpW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		3 / 3 LEU A 370
ASP A 260
ILE A 258
 None
 0.60A 6dh0B-2cfoA:
undetectable		 6dh0B-2cfoA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		3 / 3 LEU A 292
ASN A 320
LEU A 289
 None
 0.69A 6exiA-2cfoA:
undetectable		 6exiA-2cfoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2cfo GLUTAMYL-TRNA
SYNTHETASE
(Synechococcus
elongatus) 		5 / 12 ILE A 304
TRP A 280
ILE A 209
PHE A 299
ILE A 258
 None
 1.25A 6mkeA-2cfoA:
undetectable
6mkeD-2cfoA:
undetectable		 6mkeA-2cfoA:
10.45
6mkeD-2cfoA:
10.45