SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		3 / 3 PHE A1041
PHE A1030
PHE A1026
 None
 0.85A 2od9A-2cfvA:
undetectable		 2od9A-2cfvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		3 / 3 PHE A1041
PHE A1030
PHE A1026
 None
 0.85A 2qqgA-2cfvA:
undetectable		 2qqgA-2cfvA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		3 / 3 ASN A1069
ASN A1096
ARG A1278
 None
 0.70A 2rlcA-2cfvA:
undetectable		 2rlcA-2cfvA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		4 / 7 VAL A1267
VAL A1271
LEU A1274
VAL A1243
 None
 0.80A 3hs6B-2cfvA:
undetectable		 3hs6B-2cfvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		5 / 12 VAL A1237
ALA A1111
PHE A1218
PHE A1249
GLY A1247
 None
 1.26A 4mm6A-2cfvA:
undetectable		 4mm6A-2cfvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		5 / 12 GLY A1242
ILE A1110
ASN A1098
SER A1240
PHE A1123
 None
 1.24A 4obwC-2cfvA:
undetectable		 4obwC-2cfvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		3 / 3 ARG A1180
ASP A1181
ARG A1196
 None
 0.52A 4wq4B-2cfvA:
undetectable		 4wq4B-2cfvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens) 		5 / 12 GLY A1247
GLY A1244
THR A1248
GLN A1287
LEU A1274
 None
 1.09A 5kocB-2cfvA:
undetectable		 5kocB-2cfvA:
23.60