SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 122
ALA A 238
HIS A 405
GLU A 299
HIS A 306
 None
None
None
ZN  A1001 ( 2.3A)
None
 1.46A 1a4lB-2cfzA:
undetectable		 1a4lB-2cfzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 369
ASP A 363
SER A 394
ASP A 370
 None
 1.24A 1n2xA-2cfzA:
0.0		 1n2xA-2cfzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ASN A 300
TRP A 322
GLN A 274
 None
 1.42A 1xoqA-2cfzA:
undetectable		 1xoqA-2cfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 TRP A 399
ARG A  46
PHE A  49
 None
 1.30A 1zeaH-2cfzA:
undetectable
1zeaL-2cfzA:
undetectable		 1zeaH-2cfzA:
15.31
1zeaL-2cfzA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 257
PHE A 273
ILE A 135
LEU A 266
ILE A 195
 None
 0.97A 2d0kB-2cfzA:
undetectable		 2d0kB-2cfzA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 11 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.16A 2f162-2cfzA:
undetectable		 2f162-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 11 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.16A 2f16N-2cfzA:
undetectable		 2f16N-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 103
LEU A 100
ARG A  88
 None
 0.39A 3hcnB-2cfzA:
undetectable		 3hcnB-2cfzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 311
GLN A 222
SER A 508
ASN A  92
 None
 1.05A 3kp2A-2cfzA:
undetectable
3kp2B-2cfzA:
undetectable		 3kp2A-2cfzA:
12.16
3kp2B-2cfzA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 SER A 562
GLY A 595
SER A 591
 None
 0.51A 3loqA-2cfzA:
undetectable		 3loqA-2cfzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_B_ACTB600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 174
ALA A 298
GLU A 280
HIS A 169
 ZN  A1001 (-3.2A)
None
ZN  A1002 (-2.2A)
ZN  A1002 (-3.2A)
 1.39A 3mbgB-2cfzA:
1.2
3mbgC-2cfzA:
1.2		 3mbgB-2cfzA:
10.18
3mbgC-2cfzA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC600_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 280
HIS A 169
HIS A 174
ALA A 298
 ZN  A1002 (-2.2A)
ZN  A1002 (-3.2A)
ZN  A1001 (-3.2A)
None
 1.39A 3mbgB-2cfzA:
1.2
3mbgC-2cfzA:
1.2		 3mbgB-2cfzA:
10.18
3mbgC-2cfzA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.12A 3mg02-2cfzA:
undetectable
3mg0V-2cfzA:
undetectable		 3mg02-2cfzA:
15.36
3mg0V-2cfzA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 11 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.14A 3mg0N-2cfzA:
undetectable		 3mg0N-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 145
ILE A 125
ASN A 102
ASP A  53
LEU A  56
 None
 0.93A 3q87B-2cfzA:
undetectable		 3q87B-2cfzA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 510
TYR A 514
ALA A 490
LEU A 227
 None
 0.74A 3ravA-2cfzA:
undetectable		 3ravA-2cfzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 510
TYR A 514
ALA A 490
LEU A 227
 None
 0.73A 3rd0A-2cfzA:
undetectable		 3rd0A-2cfzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 176
ASP A 173
ALA A 123
HIS A 169
HIS A 344
 None
ZN  A1001 ( 2.5A)
ZN  A1001 ( 4.6A)
ZN  A1002 (-3.2A)
ZN  A1001 (-3.3A)
 0.89A 4c5nB-2cfzA:
undetectable		 4c5nB-2cfzA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 127
SER A 154
ALA A 148
ALA A 204
MET A 201
 None
 1.46A 4fe1A-2cfzA:
undetectable
4fe1J-2cfzA:
undetectable		 4fe1A-2cfzA:
21.36
4fe1J-2cfzA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 257
PHE A 273
ILE A 135
LEU A 266
ILE A 195
 None
 0.98A 4i13A-2cfzA:
undetectable		 4i13A-2cfzA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 ASN A 482
ALA A 484
LEU A 475
ARG A 457
 None
 1.10A 4ijiF-2cfzA:
undetectable		 4ijiF-2cfzA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 264
ILE A 257
LEU A 256
ARG A 255
 None
 0.70A 4mghA-2cfzA:
undetectable		 4mghA-2cfzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 169
ASP A 138
SER A 249
ASP A 173
 ZN  A1002 (-3.2A)
None
None
ZN  A1001 ( 2.5A)
 1.22A 4ndnA-2cfzA:
undetectable		 4ndnA-2cfzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 343
ASP A 138
ALA A 196
PHE A 200
 None
 1.23A 4nedA-2cfzA:
undetectable		 4nedA-2cfzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 121
LEU A 243
ARG A 312
THR A 145
 None
1DO  A1655 ( 4.7A)
1DO  A1655 (-4.3A)
None
 1.45A 4p3qA-2cfzA:
undetectable		 4p3qA-2cfzA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.13A 4qvnV-2cfzA:
undetectable
4qvnb-2cfzA:
undetectable		 4qvnV-2cfzA:
17.48
4qvnb-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.13A 4qvnH-2cfzA:
undetectable
4qvnN-2cfzA:
undetectable		 4qvnH-2cfzA:
17.48
4qvnN-2cfzA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 320
ASP A 318
LEU A 308
ILE A 326
 None
 1.15A 4y4dA-2cfzA:
undetectable		 4y4dA-2cfzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 169
ASP A 138
SER A 249
ASP A 173
 ZN  A1002 (-3.2A)
None
None
ZN  A1001 ( 2.5A)
 1.18A 5a1iA-2cfzA:
undetectable		 5a1iA-2cfzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 169
ASP A 138
SER A 249
ASP A 173
 ZN  A1002 (-3.2A)
None
None
ZN  A1001 ( 2.5A)
 1.18A 5a1iA-2cfzA:
undetectable		 5a1iA-2cfzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 169
HIS A 171
ASP A 173
HIS A 174
HIS A 344
 ZN  A1002 (-3.2A)
ZN  A1002 ( 3.2A)
ZN  A1001 ( 2.5A)
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
 0.23A 5ayaA-2cfzA:
16.9		 5ayaA-2cfzA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 7 PHE A 477
ALA A 439
PRO A 480
LEU A 475
 None
 1.15A 5dzkD-2cfzA:
undetectable
5dzkR-2cfzA:
undetectable		 5dzkD-2cfzA:
15.73
5dzkR-2cfzA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 477
ALA A 439
PRO A 480
LEU A 475
 None
 1.18A 5dzkd-2cfzA:
undetectable
5dzkr-2cfzA:
undetectable		 5dzkd-2cfzA:
15.73
5dzkr-2cfzA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 138
VAL A 165
LEU A 181
 None
 0.59A 5e5jB-2cfzA:
undetectable		 5e5jB-2cfzA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 443
GLU A 479
GLY A 448
LEU A 452
 None
 1.25A 5g5gC-2cfzA:
undetectable		 5g5gC-2cfzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  99
ASN A 102
LEU A 103
 None
 0.42A 5i1nC-2cfzA:
undetectable		 5i1nC-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  99
ASN A 102
LEU A 103
 None
 0.40A 5i1oC-2cfzA:
undetectable		 5i1oC-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  99
ASN A 102
LEU A 103
 None
 0.39A 5i1pA-2cfzA:
undetectable		 5i1pA-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  99
ASN A 102
LEU A 103
 None
 0.47A 5i1pD-2cfzA:
undetectable		 5i1pD-2cfzA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.15A 5lf7V-2cfzA:
undetectable
5lf7b-2cfzA:
undetectable		 5lf7V-2cfzA:
17.27
5lf7b-2cfzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.14A 5lf7H-2cfzA:
undetectable
5lf7N-2cfzA:
undetectable		 5lf7H-2cfzA:
17.27
5lf7N-2cfzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 169
HIS A 405
HIS A 306
HIS A 344
 ZN  A1002 (-3.2A)
None
None
ZN  A1001 (-3.3A)
 0.95A 5nelB-2cfzA:
undetectable
5nelC-2cfzA:
undetectable		 5nelB-2cfzA:
16.48
5nelC-2cfzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 405
HIS A 306
LEU A 122
HIS A 344
 None
None
None
ZN  A1001 (-3.3A)
 0.90A 5nelB-2cfzA:
undetectable
5nelC-2cfzA:
undetectable		 5nelB-2cfzA:
16.48
5nelC-2cfzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 122
ASP A 121
LEU A  82
TYR A  79
TYR A 223
 None
None
None
None
1DO  A1655 (-3.9A)
 1.01A 5uxdB-2cfzA:
undetectable		 5uxdB-2cfzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 600
LEU A 640
LEU A 542
THR A 540
PHE A 544
 None
 1.16A 5xxiA-2cfzA:
undetectable		 5xxiA-2cfzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 171
ASP A 173
HIS A 169
HIS A 344
 ZN  A1002 ( 3.2A)
ZN  A1001 ( 2.5A)
ZN  A1002 (-3.2A)
ZN  A1001 (-3.3A)
 0.95A 5zj8A-2cfzA:
19.8		 5zj8A-2cfzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 517
ALA A 490
LEU A 493
ALA A 512
 None
 1.22A 6fosB-2cfzA:
undetectable		 6fosB-2cfzA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		4 / 7 HIS A 169
ASP A 138
SER A 249
ASP A 173
 ZN  A1002 (-3.2A)
None
None
ZN  A1001 ( 2.5A)
 1.18A 6g6rA-2cfzA:
undetectable		 6g6rA-2cfzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.11A 6hwdV-2cfzA:
undetectable
6hwdb-2cfzA:
undetectable		 6hwdV-2cfzA:
8.35
6hwdb-2cfzA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 2cfz SDS HYDROLASE SDSA1
(Pseudomonas
aeruginosa) 		5 / 12 THR A 141
THR A 145
ALA A 148
GLY A 246
ALA A  73
 None
 1.12A 6hwdH-2cfzA:
undetectable
6hwdN-2cfzA:
undetectable		 6hwdH-2cfzA:
8.35
6hwdN-2cfzA:
7.47