SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GJ5_A_VD3A163_1 (BETA-LACTOGLOBULIN)	2cg4	REGULATORY PROTEIN ASNC (Escherichia coli)	5 / 12	LEU A 92 VAL A 95 ILE A 107 ILE A 74 ILE A 133	None	1.06A	2gj5A-2cg4A: undetectable	2gj5A-2cg4A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA501_1 (CYTOCHROME P450 2C8)	2cg4	REGULATORY PROTEIN ASNC (Escherichia coli)	5 / 11	GLY A 50 ALA A 21 THR A 23 VAL A 43 ILE A 13	None	1.13A	2nnhA-2cg4A: undetectable	2nnhA-2cg4A: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH504_3 (PHOSPHOLIPASE A2)	2cg4	REGULATORY PROTEIN ASNC (Escherichia coli)	5 / 11	VAL A 95 LEU A 92 ILE A 133 PRO A 83 SER A 84	None	1.14A	3bjwH-2cg4A: undetectable	3bjwH-2cg4A: 17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0P_A_TE4A201_1 (BETA-LACTOGLOBULIN)	2cg4	REGULATORY PROTEIN ASNC (Escherichia coli)	5 / 12	LEU A 92 VAL A 95 ILE A 107 ILE A 74 ILE A 133	None	0.82A	4y0pA-2cg4A: 0.5	4y0pA-2cg4A: 20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUR_E_PFLE406_1 (PROTON-GATED ION CHANNEL)	2cg4	REGULATORY PROTEIN ASNC (Escherichia coli)	5 / 10	ILE A 130 THR A 136 ILE A 74 ILE A 72 ILE A 109	None	1.01A	5murE-2cg4A: undetectable	5murE-2cg4A: 19.55

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2GJ5_A_VD3A163_1","BETA-LACTOGLOBULIN","2cg4","REGULATORY PROTEIN ASNC","Escherichia coli",5,"LEU A  92;VAL A  95;ILE A 107;ILE A  74;ILE A 133","None","1.06A","2gj5A-2cg4A:undetectable","2gj5A-2cg4A:20.13"],["2NNH_A_9CRA501_1","CYTOCHROME P450 2C8","2cg4","REGULATORY PROTEIN ASNC","Escherichia coli",5,"GLY A  50;ALA A  21;THR A  23;VAL A  43;ILE A  13","None","1.13A","2nnhA-2cg4A:undetectable","2nnhA-2cg4A:15.69"],["3BJW_H_SVRH504_3","PHOSPHOLIPASE A2","2cg4","REGULATORY PROTEIN ASNC","Escherichia coli",5,"VAL A  95;LEU A  92;ILE A 133;PRO A  83;SER A  84","None","1.14A","3bjwH-2cg4A:undetectable","3bjwH-2cg4A:17.42"],["4Y0P_A_TE4A201_1","BETA-LACTOGLOBULIN","2cg4","REGULATORY PROTEIN ASNC","Escherichia coli",5,"LEU A  92;VAL A  95;ILE A 107;ILE A  74;ILE A 133","None","0.82A","4y0pA-2cg4A:0.5","4y0pA-2cg4A:20.13"],["5MUR_E_PFLE406_1","PROTON-GATED ION CHANNEL","2cg4","REGULATORY PROTEIN ASNC","Escherichia coli",5,"ILE A 130;THR A 136;ILE A  74;ILE A  72;ILE A 109","None","1.01A","5murE-2cg4A:undetectable","5murE-2cg4A:19.55"]]