SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 4 HIS A 121
ALA A  69
PHE A  31
GLY A  73
 COA  A1300 (-3.6A)
None
None
None
 1.16A 1mj2D-2cg5A:
undetectable		 1mj2D-2cg5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 4 HIS A 121
ALA A  69
PHE A  31
GLY A  73
 COA  A1300 (-3.6A)
None
None
None
 1.12A 1mjoB-2cg5A:
undetectable		 1mjoB-2cg5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 4 HIS A 121
ALA A  69
PHE A  31
GLY A  73
 COA  A1300 (-3.6A)
None
None
None
 1.14A 1mjoA-2cg5A:
undetectable		 1mjoA-2cg5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 4 HIS A 121
ALA A  69
PHE A  31
GLY A  73
 COA  A1300 (-3.6A)
None
None
None
 1.14A 1mjoD-2cg5A:
undetectable		 1mjoD-2cg5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		5 / 11 ALA A 130
LEU A  94
LEU A 104
LYS A  84
ARG A  78
 None
MG  A1301 ( 4.9A)
None
None
MG  A1301 (-4.2A)
 1.12A 2ceoA-2cg5A:
undetectable		 2ceoA-2cg5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		5 / 10 ALA A 130
LEU A  94
LEU A 104
LYS A  84
ARG A  78
 None
MG  A1301 ( 4.9A)
None
None
MG  A1301 (-4.2A)
 1.13A 2ceoB-2cg5A:
undetectable		 2ceoB-2cg5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		5 / 10 ALA A 130
LEU A  94
LEU A 104
LYS A  84
ARG A  78
 None
MG  A1301 ( 4.9A)
None
None
MG  A1301 (-4.2A)
 1.00A 2xn6A-2cg5A:
undetectable
2xn6B-2cg5A:
undetectable		 2xn6A-2cg5A:
23.45
2xn6B-2cg5A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		5 / 11 GLU A 176
ILE A 151
SER A 150
GLY A 149
GLU A 153
 None
None
None
NI  A1302 (-4.2A)
None
 1.50A 3r76B-2cg5A:
undetectable		 3r76B-2cg5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 5 LYS A 190
LEU A 189
GLU A 166
LEU A 212
 None
 1.38A 4k4yI-2cg5A:
undetectable		 4k4yI-2cg5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 2cg5 FATTY ACID SYNTHASE
L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 201
MET A 158
PHE A 162
PHE A 183
LEU B2157
 COA  A1300 (-3.9A)
None
None
None
None
 1.45A 4la0B-2cg5A:
0.5		 4la0B-2cg5A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2cg5 FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 ALA B2130
LEU B2172
LEU B2127
LYS B2124
LEU B2166
 None
 1.41A 4x30A-2cg5B:
undetectable		 4x30A-2cg5B:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		3 / 3 LEU A 189
ALA A 188
LEU A 212
 None
 0.54A 5uunB-2cg5A:
undetectable		 5uunB-2cg5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE
(Homo
sapiens) 		4 / 8 ILE A  92
LEU A 104
ALA A 130
LEU A 128
 None
 0.79A 5y7pE-2cg5A:
undetectable		 5y7pE-2cg5A:
22.35