SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  63
VAL A  75
TRP A  60
 None
 1.27A 2xdcE-2cg8A:
undetectable
2xdcF-2cg8A:
undetectable		 2xdcE-2cg8A:
4.56
2xdcF-2cg8A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  63
VAL A  75
TRP A  60
 None
 1.22A 2y5mE-2cg8A:
undetectable
2y5mF-2cg8A:
undetectable		 2y5mE-2cg8A:
4.56
2y5mF-2cg8A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  63
VAL A  75
TRP A  60
 None
 1.24A 2y6nC-2cg8A:
undetectable
2y6nD-2cg8A:
undetectable		 2y6nC-2cg8A:
4.56
2y6nD-2cg8A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 TRP A  63
VAL A  75
TRP A  60
 None
 1.23A 2y6nE-2cg8A:
undetectable
2y6nF-2cg8A:
undetectable		 2y6nE-2cg8A:
4.56
2y6nF-2cg8A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 238
ILE A 124
LEU A 187
GLU A 195
 None
 1.06A 2ya7A-2cg8A:
undetectable		 2ya7A-2cg8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 238
ILE A 124
LEU A 187
GLU A 195
 None
 1.06A 2ya7B-2cg8A:
undetectable		 2ya7B-2cg8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 238
ILE A 124
LEU A 187
GLU A 195
 None
 1.04A 2ya7D-2cg8A:
2.2		 2ya7D-2cg8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 ASP A 227
LEU A 223
ASP A 186
LEU A 182
 None
 1.19A 3bj8C-2cg8A:
undetectable
3bj8D-2cg8A:
undetectable		 3bj8C-2cg8A:
20.65
3bj8D-2cg8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 PRO A 260
ILE A 261
PRO A 250
TYR A 265
 None
 1.28A 3d9lA-2cg8A:
undetectable
3d9lY-2cg8A:
undetectable		 3d9lA-2cg8A:
18.75
3d9lY-2cg8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 215
VAL A 176
ILE A 141
ALA A 122
ILE A 124
 None
 0.96A 3el0B-2cg8A:
undetectable		 3el0B-2cg8A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 228
GLN A 120
LEU A 187
THR A 190
LEU A 230
 None
 1.40A 3fsuA-2cg8A:
undetectable		 3fsuA-2cg8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A  79
ALA A  32
ILE A  33
ILE A  29
LEU A  95
 None
 0.94A 3ogpA-2cg8A:
undetectable		 3ogpA-2cg8A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A  79
ALA A  32
ILE A  33
ILE A  29
LEU A  95
 None
 0.94A 3ogqA-2cg8A:
undetectable		 3ogqA-2cg8A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 LEU A  34
ALA A  32
LEU A   4
VAL A  30
 None
 0.89A 4iizB-2cg8A:
undetectable		 4iizB-2cg8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 241
LEU A 245
VAL A 175
 None
 0.52A 4wq4A-2cg8A:
undetectable		 4wq4A-2cg8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 191
ALA A 140
VAL A 178
ILE A 151
 None
 0.92A 4xe3A-2cg8A:
undetectable		 4xe3A-2cg8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  13
THR A 110
PHE A  28
THR A 114
GLU A  10
 None
 1.32A 5hfjC-2cg8A:
undetectable		 5hfjC-2cg8A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  13
THR A 110
PHE A  28
THR A 114
GLU A  10
 None
 1.36A 5hfjG-2cg8A:
undetectable		 5hfjG-2cg8A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 GLN A  59
THR A  67
HIS A  15
LEU A  79
 None
 1.44A 6aphA-2cg8A:
undetectable		 6aphA-2cg8A:
19.12