SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cg9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2cg9 CO-CHAPERONE PROTEIN
SBA1
(Saccharomyces
cerevisiae) 		4 / 4 GLU X 129
TYR X 103
PRO X 105
ASP X 126
 None
 1.44A 1i7zD-2cg9X:
1.6		 1i7zD-2cg9X:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 GLU A  76
ILE A 172
GLU A 165
ILE A 167
ILE A 137
 None
 1.22A 2j9dD-2cg9A:
0.0
2j9dE-2cg9A:
0.0
2j9dF-2cg9A:
0.0		 2j9dD-2cg9A:
11.37
2j9dE-2cg9A:
11.23
2j9dF-2cg9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2cg9 CO-CHAPERONE PROTEIN
SBA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU X  49
ILE X  47
VAL X  84
THR X  80
MET X  81
 None
 1.32A 2qo4A-2cg9X:
undetectable		 2qo4A-2cg9X:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 358
PHE A 404
PHE A 417
PRO A 328
PHE A 421
 None
 1.08A 2ygpA-2cg9A:
undetectable		 2ygpA-2cg9A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 289
ILE A 396
LEU A 321
PHE A 322
 None
 1.24A 3ls4L-2cg9A:
undetectable		 3ls4L-2cg9A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2cg9 CO-CHAPERONE PROTEIN
SBA1
(Saccharomyces
cerevisiae) 		3 / 3 TYR X  95
ASP X  20
ASP X 122
 None
 0.75A 3ou6B-2cg9X:
undetectable		 3ou6B-2cg9X:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 4 SER A 138
GLY A 100
GLU A 106
 None
ATP  A1678 (-3.3A)
None
 0.66A 3raeA-2cg9A:
undetectable
3raeC-2cg9A:
undetectable		 3raeA-2cg9A:
23.31
3raeC-2cg9A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 356
LEU A 357
ILE A 350
PHE A 349
 None
 1.16A 3s3vA-2cg9A:
undetectable		 3s3vA-2cg9A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 651
ALA A 587
ILE A 474
GLY A 476
LEU A 652
 None
 0.91A 3u7sA-2cg9A:
undetectable		 3u7sA-2cg9A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 SER A 138
SER A 140
LEU A  42
THR A 171
 None
None
None
ATP  A1678 (-3.9A)
 0.85A 4ikjA-2cg9A:
undetectable
4ikjB-2cg9A:
undetectable		 4ikjA-2cg9A:
11.16
4ikjB-2cg9A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A  42
THR A 171
SER A 138
SER A 140
 None
ATP  A1678 (-3.9A)
None
None
 0.91A 4ikkA-2cg9A:
undetectable
4ikkB-2cg9A:
undetectable		 4ikkA-2cg9A:
11.16
4ikkB-2cg9A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 400
PHE A 404
ALA A 438
GLY A 428
LEU A 439
 None
 1.17A 4j7xB-2cg9A:
undetectable		 4j7xB-2cg9A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 4 SER A 138
GLY A 100
GLU A 106
 None
ATP  A1678 (-3.3A)
None
 0.60A 4juoA-2cg9A:
undetectable
4juoC-2cg9A:
10.4		 4juoA-2cg9A:
23.31
4juoC-2cg9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 374
SER A  39
VAL A 122
GLY A 123
 None
None
ATP  A1678 (-3.8A)
ATP  A1678 (-3.3A)
 0.97A 4klrB-2cg9A:
undetectable		 4klrB-2cg9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 136
LEU A  89
LEU A  93
ASP A  40
 None
None
None
ATP  A1678 ( 4.9A)
 0.84A 4lzrA-2cg9A:
undetectable		 4lzrA-2cg9A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
CO-CHAPERONE PROTEIN
SBA1
(Saccharomyces
cerevisiae) 		4 / 8 THR X  19
SER X  17
GLU A 316
TYR X  72
 None
 1.40A 4qb9D-2cg9X:
undetectable		 4qb9D-2cg9X:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  35
LEU A 185
VAL A 208
LEU A 207
 None
 0.97A 4r38B-2cg9A:
undetectable		 4r38B-2cg9A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 498
PHE A 487
ARG A 579
 None
 0.71A 4xr4B-2cg9A:
undetectable		 4xr4B-2cg9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
CO-CHAPERONE PROTEIN
SBA1
(Saccharomyces
cerevisiae) 		3 / 3 PHE X 121
ILE A 388
ASP X 128
 None
 0.75A 5cswB-2cg9X:
undetectable		 5cswB-2cg9X:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 503
ASN A 446
PHE A 421
 None
 0.91A 5jglB-2cg9A:
undetectable		 5jglB-2cg9A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 318
ARG A 347
ARG A 279
 None
 0.70A 5vcgA-2cg9A:
undetectable		 5vcgA-2cg9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 1.02A 6bqgA-2cg9A:
undetectable		 6bqgA-2cg9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 142
ASP A  52
ASP A  79
THR A 171
THR A  58
 None
None
ATP  A1678 (-3.2A)
ATP  A1678 (-3.9A)
None
 1.11A 6mn1B-2cg9A:
0.0		 6mn1B-2cg9A:
8.77