SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 613
LEU A 652
ALA A 650
ALA A 576
LEU A 550
 None
 1.16A 1cbrA-2cgeA:
undetectable		 1cbrA-2cgeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 613
LEU A 652
ALA A 650
ALA A 576
LEU A 550
 None
 1.17A 1cbrB-2cgeA:
undetectable		 1cbrB-2cgeA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 559
GLU A 556
ASP A 560
 None
 0.69A 2b25B-2cgeA:
undetectable		 2b25B-2cgeA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 SER A 419
PHE A 421
LYS A 423
 None
 0.93A 3u88A-2cgeA:
undetectable		 3u88A-2cgeA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 7 SER A 485
GLY A 476
THR A 475
ILE A 474
 None
 0.96A 4acaC-2cgeA:
undetectable		 4acaC-2cgeA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 393
LYS A 394
LYS A 390
 None
 1.24A 4k50A-2cgeA:
undetectable		 4k50A-2cgeA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 393
LYS A 394
LYS A 390
 None
 1.26A 4k50E-2cgeA:
undetectable		 4k50E-2cgeA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 393
LYS A 394
LYS A 390
 None
 1.28A 4k50I-2cgeA:
undetectable		 4k50I-2cgeA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 6 SER A 450
GLU A 453
THR A 462
ARG A 463
 None
 1.38A 4lnxA-2cgeA:
undetectable		 4lnxA-2cgeA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 474
ILE A 524
ASN A 588
ALA A 587
 None
 0.99A 4ou1A-2cgeA:
undetectable		 4ou1A-2cgeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 8 VAL A 562
ILE A 578
ALA A 577
VAL A 566
VAL A 565
 None
 1.10A 5l94A-2cgeA:
undetectable		 5l94A-2cgeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 650
THR A 649
GLU A 648
GLY A 655
ASP A 659
 None
 1.22A 5lf3H-2cgeA:
undetectable
5lf3I-2cgeA:
undetectable		 5lf3H-2cgeA:
21.16
5lf3I-2cgeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 650
THR A 649
GLU A 648
GLY A 655
ASP A 659
 None
 1.20A 5lf3V-2cgeA:
undetectable
5lf3W-2cgeA:
undetectable		 5lf3V-2cgeA:
21.16
5lf3W-2cgeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 625
ILE A 615
PRO A 575
ALA A 576
PHE A 613
 None
 1.34A 5m0oA-2cgeA:
undetectable		 5m0oA-2cgeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 346
PHE A 349
LEU A 376
 None
 0.81A 5x1bC-2cgeA:
undetectable		 5x1bC-2cgeA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 1.00A 6bqgA-2cgeA:
2.3		 6bqgA-2cgeA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 558
LEU A 651
THR A 612
PRO A 486
 None
 0.82A 6ew0F-2cgeA:
undetectable		 6ew0F-2cgeA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 558
LEU A 651
THR A 612
PRO A 486
 None
 0.82A 6ew0G-2cgeA:
undetectable		 6ew0G-2cgeA:
12.34