SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 TYR A 163
PHE A 164
MET A 160
THR A  50
 None
 1.27A 1ea1A-2cgjA:
undetectable		 1ea1A-2cgjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.19A 1v55C-2cgjA:
undetectable
1v55N-2cgjA:
undetectable
1v55P-2cgjA:
undetectable		 1v55C-2cgjA:
19.22
1v55N-2cgjA:
22.18
1v55P-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 GLU A 288
GLY A 285
MET A 439
ALA A 239
ALA A 234
 None
 1.00A 1x7pA-2cgjA:
undetectable
1x7pB-2cgjA:
undetectable		 1x7pA-2cgjA:
23.75
1x7pB-2cgjA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 LEU A 431
SER A 240
VAL A 447
ARG A 451
VAL A 454
 None
 0.90A 2kawA-2cgjA:
undetectable		 2kawA-2cgjA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 GLY A 285
ARG A 292
TYR A 176
 None
 0.84A 2opxA-2cgjA:
undetectable		 2opxA-2cgjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.11A 2qd5A-2cgjA:
undetectable		 2qd5A-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 315
SER A  15
VAL A 426
GLY A 401
 ADP  A1482 (-4.9A)
None
None
ADP  A1482 ( 3.9A)
 1.07A 2qd5B-2cgjA:
undetectable		 2qd5B-2cgjA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 VAL A 447
ASP A 448
GLU A 288
 None
 0.70A 2qeuA-2cgjA:
undetectable		 2qeuA-2cgjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 VAL A 447
ASP A 448
GLU A 288
 None
 0.72A 2qeuC-2cgjA:
undetectable		 2qeuC-2cgjA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 TYR A 254
LEU A 383
VAL A 382
LEU A 386
 None
 0.79A 2w98B-2cgjA:
undetectable		 2w98B-2cgjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.83A 2zthA-2cgjA:
undetectable		 2zthA-2cgjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.20A 3asoC-2cgjA:
undetectable
3asoN-2cgjA:
undetectable
3asoP-2cgjA:
undetectable		 3asoC-2cgjA:
19.22
3asoN-2cgjA:
22.18
3asoP-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.72A 3bwmA-2cgjA:
undetectable		 3bwmA-2cgjA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.75A 3bwyA-2cgjA:
undetectable		 3bwyA-2cgjA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 HIS A 236
SER A 240
ILE A 243
ARG A 292
 LFR  A1481 (-3.9A)
None
None
None
 1.10A 3sfeB-2cgjA:
undetectable
3sfeC-2cgjA:
undetectable		 3sfeB-2cgjA:
19.31
3sfeC-2cgjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 424
GLY A 401
GLN A 411
VAL A 421
ALA A 414
 None
ADP  A1482 ( 3.9A)
None
None
None
 1.20A 3t7vA-2cgjA:
undetectable		 3t7vA-2cgjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 6 GLY A  12
ASP A 162
ASP A  10
GLU A 175
 ADP  A1482 ( 4.0A)
None
None
None
 1.03A 3vywC-2cgjA:
undetectable		 3vywC-2cgjA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 ALA A  13
SER A  14
THR A 181
SER A 235
TRP A  82
 ADP  A1482 ( 4.9A)
ADP  A1482 (-2.4A)
None
None
None
 1.48A 4bb2A-2cgjA:
undetectable
4bb2B-2cgjA:
0.0		 4bb2A-2cgjA:
23.39
4bb2B-2cgjA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 LEU A 397
ILE A 422
ILE A 419
THR A 462
PHE A 463
 None
 1.04A 4fakA-2cgjA:
undetectable		 4fakA-2cgjA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 9 ASN A 186
ILE A 187
GLY A 128
THR A 272
ASP A 193
 None
 1.02A 4fxsA-2cgjA:
undetectable		 4fxsA-2cgjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 401
GLY A 402
GLY A 403
SER A 261
ALA A 241
 ADP  A1482 ( 3.9A)
ADP  A1482 (-3.2A)
ADP  A1482 (-3.9A)
None
None
 0.92A 4htfA-2cgjA:
undetectable		 4htfA-2cgjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLY A 401
GLY A 402
GLY A 403
SER A 261
ALA A 241
 ADP  A1482 ( 3.9A)
ADP  A1482 (-3.2A)
ADP  A1482 (-3.9A)
None
None
 0.94A 4htfB-2cgjA:
undetectable		 4htfB-2cgjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 LEU A 300
LEU A 318
ILE A 319
LEU A 315
LEU A 409
 ADP  A1482 (-3.6A)
None
None
ADP  A1482 (-4.9A)
None
 1.07A 4odoC-2cgjA:
undetectable		 4odoC-2cgjA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qvmV-2cgjA:
undetectable
4qvmb-2cgjA:
undetectable		 4qvmV-2cgjA:
17.68
4qvmb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 4qvmH-2cgjA:
undetectable
4qvmN-2cgjA:
undetectable		 4qvmH-2cgjA:
17.68
4qvmN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw0V-2cgjA:
undetectable
4qw0b-2cgjA:
undetectable		 4qw0V-2cgjA:
17.68
4qw0b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 4qw0H-2cgjA:
undetectable
4qw0N-2cgjA:
undetectable		 4qw0H-2cgjA:
17.68
4qw0N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw1V-2cgjA:
undetectable
4qw1b-2cgjA:
undetectable		 4qw1V-2cgjA:
17.68
4qw1b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 4qw1H-2cgjA:
undetectable
4qw1N-2cgjA:
undetectable		 4qw1H-2cgjA:
17.68
4qw1N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.47A 4qw3V-2cgjA:
undetectable
4qw3b-2cgjA:
undetectable		 4qw3V-2cgjA:
17.68
4qw3b-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.47A 4qw3H-2cgjA:
undetectable
4qw3N-2cgjA:
undetectable		 4qw3H-2cgjA:
17.68
4qw3N-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 ARG A 106
GLU A 149
TYR A  48
 None
 0.87A 4r29D-2cgjA:
undetectable		 4r29D-2cgjA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 4 ILE A 217
ASN A 215
ILE A 436
VAL A 233
 None
 1.18A 4uy87-2cgjA:
undetectable		 4uy87-2cgjA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 4 ASN A 173
SER A 235
ALA A 232
VAL A 231
 None
 1.15A 4x1kC-2cgjA:
undetectable		 4x1kC-2cgjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 9 SER A 165
GLU A  57
LEU A 158
LEU A  89
 None
 0.87A 4xtaA-2cgjA:
undetectable		 4xtaA-2cgjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 SER A 256
GLU A 427
ASP A 237
 None
None
LFR  A1481 (-3.0A)
 0.70A 4xudA-2cgjA:
undetectable		 4xudA-2cgjA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 8 ALA A 244
PRO A 425
VAL A 454
PHE A 450
GLY A 432
 None
 0.90A 4zjzB-2cgjA:
undetectable		 4zjzB-2cgjA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 THR A 107
TYR A 138
TRP A 260
LEU A 140
 None
None
LFR  A1481 (-4.1A)
None
 1.10A 5b1bA-2cgjA:
undetectable
5b1bC-2cgjA:
undetectable
5b1bP-2cgjA:
undetectable		 5b1bA-2cgjA:
22.18
5b1bC-2cgjA:
19.22
5b1bP-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.50A 5bxnV-2cgjA:
undetectable
5bxnb-2cgjA:
undetectable		 5bxnV-2cgjA:
17.68
5bxnb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.49A 5bxnH-2cgjA:
undetectable
5bxnN-2cgjA:
undetectable		 5bxnH-2cgjA:
17.68
5bxnN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.45A 5d0xV-2cgjA:
undetectable
5d0xb-2cgjA:
undetectable		 5d0xV-2cgjA:
17.68
5d0xb-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 SER A 235
THR A 282
THR A 180
ARG A 292
THR A 238
 None
None
None
None
LFR  A1481 (-3.4A)
 1.46A 5d0xH-2cgjA:
undetectable
5d0xN-2cgjA:
undetectable		 5d0xH-2cgjA:
17.68
5d0xN-2cgjA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 ILE A 371
LEU A 408
LEU A 375
ALA A 376
VAL A 306
 None
 1.25A 5ji0A-2cgjA:
undetectable		 5ji0A-2cgjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 LEU A 438
ILE A 434
PHE A 450
ALA A  21
VAL A 453
 None
 1.23A 5m0oA-2cgjA:
undetectable		 5m0oA-2cgjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 VAL A 400
ALA A 241
SER A 245
THR A 181
LEU A 294
 None
 1.36A 5m54B-2cgjA:
undetectable		 5m54B-2cgjA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 8 PRO A 213
ILE A 243
TYR A 176
THR A 177
 None
 0.86A 5mzrE-2cgjA:
undetectable		 5mzrE-2cgjA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 4 ASN A 215
SER A 235
ALA A 232
VAL A 231
 None
 1.06A 5nm5A-2cgjA:
undetectable		 5nm5A-2cgjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 318
ALA A 317
LEU A 307
 None
 0.54A 5uunB-2cgjA:
undetectable		 5uunB-2cgjA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 12 GLN A 350
ALA A 351
GLU A 309
LEU A 367
ILE A 371
 None
 1.00A 5vlmG-2cgjA:
undetectable		 5vlmG-2cgjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 LEU A 140
THR A 107
TYR A 138
TRP A 260
 None
None
None
LFR  A1481 (-4.1A)
 1.23A 5z84C-2cgjA:
undetectable
5z84N-2cgjA:
undetectable
5z84P-2cgjA:
undetectable		 5z84C-2cgjA:
19.22
5z84N-2cgjA:
22.18
5z84P-2cgjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 196
THR A 282
ASN A 283
 None
 0.70A 6baaE-2cgjA:
undetectable		 6baaE-2cgjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 196
THR A 282
ASN A 283
 None
 0.70A 6baaF-2cgjA:
undetectable		 6baaF-2cgjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 196
THR A 282
ASN A 283
 None
 0.70A 6baaG-2cgjA:
undetectable		 6baaG-2cgjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 LEU A 196
THR A 282
ASN A 283
 None
 0.70A 6baaH-2cgjA:
undetectable		 6baaH-2cgjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 5 TYR A 124
GLN A 183
GLY A 264
ILE A 281
 None
 1.10A 6debB-2cgjA:
undetectable		 6debB-2cgjA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		3 / 3 GLY A  12
ASP A  10
ILE A  79
 ADP  A1482 ( 4.0A)
None
None
 0.56A 6dgxB-2cgjA:
undetectable		 6dgxB-2cgjA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 11 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.46A 6mb5A-2cgjA:
undetectable		 6mb5A-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.49A 6mb7A-2cgjA:
0.0		 6mb7A-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.50A 6mb9A-2cgjA:
0.0		 6mb9A-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_B_NMYB302_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.50A 6mb9B-2cgjA:
0.0		 6mb9B-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_C_NMYC302_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.49A 6mb9C-2cgjA:
0.0		 6mb9C-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		5 / 10 TYR A 176
ASP A 190
TYR A 291
THR A 181
GLY A 128
 None
 1.46A 6mb9D-2cgjA:
0.0		 6mb9D-2cgjA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cgj L-RHAMNULOSE KINASE
(Escherichia
coli) 		4 / 7 THR A 107
TYR A 138
TRP A 260
LEU A 140
 None
None
LFR  A1481 (-4.1A)
None
 1.18A 6nmfA-2cgjA:
undetectable
6nmfC-2cgjA:
undetectable
6nmfP-2cgjA:
undetectable		 6nmfA-2cgjA:
22.18
6nmfC-2cgjA:
19.22
6nmfP-2cgjA:
19.22