SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ch1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 7 ASP A 127
GLY A 102
ILE A 103
ALA A 182
 None
None
None
PLP  A1390 (-3.5A)
 0.79A 1n49A-2ch1A:
undetectable		 1n49A-2ch1A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 GLY A  25
ASP A 179
ILE A 177
GLY A  81
SER A  77
 GOL  A1391 ( 4.7A)
PLP  A1390 (-3.0A)
None
None
PLP  A1390 (-2.7A)
 1.20A 1q8jB-2ch1A:
2.2		 1q8jB-2ch1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 8 PRO A 215
LEU A 207
GLY A 208
LEU A 268
 None
 0.94A 1ya4A-2ch1A:
undetectable		 1ya4A-2ch1A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 LEU A  97
LEU A  89
LEU A 149
ILE A 168
HIS A 172
 None
 1.06A 2ouzA-2ch1A:
undetectable		 2ouzA-2ch1A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 HIS A  79
ASP A 153
PHE A 148
ILE A 103
ASP A 179
 PLP  A1390 (-3.7A)
None
None
None
PLP  A1390 (-3.0A)
 1.18A 2pgrA-2ch1A:
undetectable		 2pgrA-2ch1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 9 PRO A 215
LEU A  60
ALA A 203
LEU A 268
ALA A 271
 None
 1.22A 2vcvD-2ch1A:
undetectable		 2vcvD-2ch1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 PHE A 130
GLN A 160
LEU A 147
LEU A 149
 None
 0.96A 3bgdA-2ch1A:
undetectable		 3bgdA-2ch1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		3 / 3 MET A  37
CYH A  29
PRO A 211
 None
 1.25A 3h52C-2ch1A:
undetectable		 3h52C-2ch1A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 8 ASN A  88
LEU A 175
ALA A 198
SER A 219
 None
 0.95A 3kp6A-2ch1A:
undetectable		 3kp6A-2ch1A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 7 LEU A 373
LEU A 294
SER A 364
THR A 316
 None
 0.99A 3lm8A-2ch1A:
2.4
3lm8C-2ch1A:
2.4		 3lm8A-2ch1A:
20.40
3lm8C-2ch1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 7 LEU A 132
GLU A 133
GLU A 140
ILE A 168
 None
 0.81A 3s56B-2ch1A:
undetectable		 3s56B-2ch1A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 8 GLY A  81
ALA A  80
GLY A 212
ILE A 213
 None
 0.68A 3so9A-2ch1A:
undetectable		 3so9A-2ch1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 11 ALA A 267
LEU A 184
GLY A 202
ILE A 275
PHE A 189
 None
 1.11A 3zosA-2ch1A:
undetectable
3zosB-2ch1A:
undetectable		 3zosA-2ch1A:
22.09
3zosB-2ch1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 8 ASN A  68
ALA A  70
GLU A 252
LEU A 223
 None
 0.96A 4jjkA-2ch1A:
2.5		 4jjkA-2ch1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 GLU A 252
ASN A 245
LEU A 240
ILE A 216
LEU A  60
 None
 1.45A 4k36A-2ch1A:
undetectable		 4k36A-2ch1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 GLU A 252
ASN A 245
LEU A 240
ILE A 216
LEU A  60
 None
 1.47A 4k36B-2ch1A:
undetectable		 4k36B-2ch1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 GLU A 252
ASN A 245
LEU A 240
ILE A 216
LEU A  60
 None
 1.38A 4k39A-2ch1A:
undetectable		 4k39A-2ch1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 ALA A 180
TYR A 200
GLY A 102
SER A 154
GLY A 152
 None
None
None
PLP  A1390 ( 2.4A)
None
 0.88A 4mmdB-2ch1A:
undetectable		 4mmdB-2ch1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 9 ALA A 180
ILE A  63
ILE A 284
THR A  66
VAL A 199
 None
 1.16A 4nptA-2ch1A:
undetectable		 4nptA-2ch1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 GLU A 123
GLY A 319
ARG A 356
GLY A 157
 None
None
GOL  A1391 (-3.1A)
None
 0.87A 5cdnC-2ch1A:
undetectable
5cdnD-2ch1A:
undetectable		 5cdnC-2ch1A:
21.41
5cdnD-2ch1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 GLU A 123
GLY A 319
ARG A 356
GLY A 157
 None
None
GOL  A1391 (-3.1A)
None
 0.91A 5cdnT-2ch1A:
2.0
5cdnU-2ch1A:
undetectable		 5cdnT-2ch1A:
21.41
5cdnU-2ch1A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 12 GLY A 157
GLY A 152
ASP A 179
TRP A 104
GLY A 346
 None
None
PLP  A1390 (-3.0A)
PLP  A1390 ( 3.4A)
None
 1.21A 5hikA-2ch1A:
4.1		 5hikA-2ch1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 ARG A 356
GLY A  23
SER A 154
THR A 316
 GOL  A1391 (-3.1A)
None
PLP  A1390 ( 2.4A)
None
 1.20A 5ysiA-2ch1A:
undetectable		 5ysiA-2ch1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 5 ASN A  44
VAL A  56
LEU A  60
SER A  75
 None
 1.30A 6a7pA-2ch1A:
undetectable		 6a7pA-2ch1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 5 LEU A 176
LEU A 135
THR A 150
ARG A 311
 None
 1.10A 6ew0F-2ch1A:
undetectable		 6ew0F-2ch1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 LEU A 176
LEU A 135
THR A 150
ARG A 311
 None
 1.11A 6ew0G-2ch1A:
undetectable		 6ew0G-2ch1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		4 / 6 PHE A 189
LEU A 184
ALA A 180
THR A  71
 None
 1.00A 6f88A-2ch1A:
undetectable		 6f88A-2ch1A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE
(Anopheles
gambiae) 		5 / 11 MET A 191
PHE A  64
ILE A  63
LEU A  60
MET A  85
 None
 1.46A 6fgcA-2ch1A:
2.3		 6fgcA-2ch1A:
12.88