SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ch6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		4 / 8 PHE A 216
ILE A 220
HIS A 161
VAL A 184
 None
 0.82A 1fslB-2ch6A:
undetectable		 1fslB-2ch6A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		4 / 5 LEU A  19
ALA A 316
SER A  70
LYS A  57
 None
 0.74A 2othA-2ch6A:
undetectable		 2othA-2ch6A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 11 SER A 111
ALA A 113
GLY A 110
ALA A 109
ARG A 321
 None
 1.42A 2xh9A-2ch6A:
undetectable		 2xh9A-2ch6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 11 SER A 111
TYR A 331
ALA A 113
GLY A 110
ALA A 109
 None
 1.45A 2xh9A-2ch6A:
undetectable		 2xh9A-2ch6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 10 SER A 111
ALA A 113
GLY A 110
ALA A 109
ARG A 321
 None
 1.42A 2xh9B-2ch6A:
undetectable		 2xh9B-2ch6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 10 SER A 111
TYR A 331
ALA A 113
GLY A 110
ALA A 109
 None
 1.46A 2xh9B-2ch6A:
undetectable		 2xh9B-2ch6A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		4 / 4 SER A 129
GLY A 128
GLY A 144
GLY A 151
 None
GLC  A1001 (-3.6A)
None
None
 0.74A 3bogB-2ch6A:
undetectable
3bogD-2ch6A:
undetectable		 3bogB-2ch6A:
undetectable
3bogD-2ch6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 GLY A  77
ASP A 107
ILE A 124
ASN A  36
THR A 127
 GLC  A1001 ( 4.6A)
GLC  A1001 (-2.9A)
GLC  A1001 (-4.0A)
None
ADP  A 470 (-3.3A)
 1.19A 3eeyJ-2ch6A:
undetectable		 3eeyJ-2ch6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.35A 3medA-2ch6A:
4.4
3medB-2ch6A:
3.6		 3medA-2ch6A:
20.63
3medB-2ch6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.38A 3megA-2ch6A:
1.3		 3megA-2ch6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 GLY A 239
GLY A 282
LEU A 278
SER A 275
ALA A 238
 None
None
None
ADP  A 470 (-2.8A)
None
 1.17A 3sxjA-2ch6A:
undetectable		 3sxjA-2ch6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 GLY A 239
GLY A 282
LEU A 278
SER A 275
ALA A 238
 None
None
None
ADP  A 470 (-2.8A)
None
 1.17A 3sxjB-2ch6A:
undetectable		 3sxjB-2ch6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 TYR A 331
GLY A 315
GLY A 110
ALA A 320
LEU A 327
 None
 1.16A 3vywA-2ch6A:
undetectable		 3vywA-2ch6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 TYR A 331
GLY A 315
GLY A 110
ALA A 320
LEU A 327
 None
 1.16A 3vywD-2ch6A:
undetectable		 3vywD-2ch6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 8 ILE A 266
LEU A 123
MET A 241
LYS A 237
GLY A 239
 None
 1.49A 4hb6A-2ch6A:
undetectable		 4hb6A-2ch6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 8 ILE A 266
LEU A 123
MET A 241
LYS A 237
GLY A 239
 None
 1.35A 4hb8A-2ch6A:
undetectable		 4hb8A-2ch6A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 1.00A 4otyA-2ch6A:
undetectable		 4otyA-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 1.00A 4otyB-2ch6A:
0.1		 4otyB-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		3 / 3 LEU A 264
MET A 305
TYR A 341
 None
 0.77A 4p6xG-2ch6A:
undetectable		 4p6xG-2ch6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 1.03A 4rrwC-2ch6A:
undetectable		 4rrwC-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 0.96A 4rrwD-2ch6A:
undetectable		 4rrwD-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 1.03A 4rrzC-2ch6A:
undetectable		 4rrzC-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  75
SER A  76
LEU A 318
GLY A 110
SER A 311
 None
 0.96A 4rrzD-2ch6A:
undetectable		 4rrzD-2ch6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 GLY A 239
GLU A 153
GLY A 154
ILE A 266
GLY A 243
 None
 1.02A 4yvgA-2ch6A:
undetectable		 4yvgA-2ch6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.24A 5cymA-2ch6A:
4.4		 5cymA-2ch6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.23A 5cyqA-2ch6A:
4.2		 5cyqA-2ch6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		4 / 6 GLU A  22
TYR A   5
GLY A   6
GLY A   7
 None
 0.93A 5x7pB-2ch6A:
undetectable		 5x7pB-2ch6A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2ch6 N-ACETYL-D-GLUCOSAMI
NE KINASE
(Homo
sapiens) 		5 / 12 LEU A  71
VAL A  46
PHE A  95
LEU A  98
TYR A 102
 None
 1.25A 6eliA-2ch6A:
4.5		 6eliA-2ch6A:
11.68