SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2chc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2O5Y_H_STRH249_1 (CHIMERIC ANTIBODY FAB 1E9-DB3)	2chc	PROTEIN RV3472 (Mycobacterium tuberculosis)	4 / 7	ASN A 26 GLY A 69 THR A 94 SER A 91	None	1.23A	2o5yH-2chcA: undetectable 2o5yL-2chcA: undetectable	2o5yH-2chcA: 19.74 2o5yL-2chcA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCV_L_ASDL1224_1 (GLUTATHIONE S-TRANSFERASE A3)	2chc	PROTEIN RV3472 (Mycobacterium tuberculosis)	4 / 7	ALA A 62 LEU A 154 ALA A 158 PHE A 45	None	1.09A	2vcvL-2chcA: undetectable	2vcvL-2chcA: 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A210_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	2chc	PROTEIN RV3472 (Mycobacterium tuberculosis)	5 / 12	VAL A 66 LEU A 104 VAL A 93 TYR A 21 TYR A 109	None	1.45A	5i8fA-2chcA: undetectable	5i8fA-2chcA: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FOS_B_PQNB2002_1 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2)	2chc	PROTEIN RV3472 (Mycobacterium tuberculosis)	4 / 6	ARG A 57 ALA A 34 LEU A 56 ALA A 55	None	1.17A	6fosB-2chcA: undetectable	6fosB-2chcA: 17.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2O5Y_H_STRH249_1","CHIMERIC ANTIBODY FAB 1E9-DB3;CHIMERIC ANTIBODY FAB 1E9-DB3","2chc","PROTEIN RV3472","Mycobacterium tuberculosis",4,"ASN A  26;GLY A  69;THR A  94;SER A  91","None","1.23A","2o5yH-2chcA:undetectable;2o5yL-2chcA:undetectable","2o5yH-2chcA:19.74;2o5yL-2chcA:20.18"],["2VCV_L_ASDL1224_1","GLUTATHIONE S-TRANSFERASE A3","2chc","PROTEIN RV3472","Mycobacterium tuberculosis",4,"ALA A  62;LEU A 154;ALA A 158;PHE A  45","None","1.09A","2vcvL-2chcA:undetectable","2vcvL-2chcA:22.17"],["5I8F_A_ML1A210_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","2chc","PROTEIN RV3472","Mycobacterium tuberculosis",5,"VAL A  66;LEU A 104;VAL A  93;TYR A  21;TYR A 109","None","1.45A","5i8fA-2chcA:undetectable","5i8fA-2chcA:21.93"],["6FOS_B_PQNB2002_1","PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A2","2chc","PROTEIN RV3472","Mycobacterium tuberculosis",4,"ARG A  57;ALA A  34;LEU A  56;ALA A  55","None","1.17A","6fosB-2chcA:undetectable","6fosB-2chcA:17.26"]]