SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2chg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.92A 1mt1A-2chgA:
undetectable
1mt1F-2chgA:
undetectable		 1mt1A-2chgA:
13.99
1mt1F-2chgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 ILE A  26
GLU A  34
ASP A  61
LEU A  58
 None
 0.96A 1mt1B-2chgA:
undetectable
1mt1C-2chgA:
undetectable		 1mt1B-2chgA:
20.27
1mt1C-2chgA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.91A 1n13A-2chgA:
undetectable
1n13F-2chgA:
undetectable		 1n13A-2chgA:
13.99
1n13F-2chgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 7 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.88A 1n13I-2chgA:
undetectable
1n13L-2chgA:
undetectable		 1n13I-2chgA:
13.99
1n13L-2chgA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 ILE A  26
GLU A  34
ASP A  61
LEU A  58
 None
 0.90A 2qqdB-2chgA:
undetectable
2qqdC-2chgA:
undetectable		 2qqdB-2chgA:
19.37
2qqdC-2chgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 8 ALA A 113
LEU A 114
LEU A 122
ILE A 145
ILE A 106
 None
 1.40A 2uxpA-2chgA:
undetectable		 2uxpA-2chgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 1.18A 3adsB-2chgA:
undetectable		 3adsB-2chgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 122
ILE A 149
CYH A 153
LEU A 137
SER A 132
 None
 1.15A 3ko0K-2chgA:
2.4
3ko0L-2chgA:
2.4
3ko0S-2chgA:
2.1
3ko0T-2chgA:
undetectable		 3ko0K-2chgA:
23.08
3ko0L-2chgA:
23.08
3ko0S-2chgA:
23.08
3ko0T-2chgA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 GLU A  91
LYS A  90
TYR A 129
LYS A 104
 None
 1.07A 3pocB-2chgA:
2.5		 3pocB-2chgA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		3 / 3 GLY A  48
GLY A  50
THR A  52
 ANP  A1227 (-3.4A)
ANP  A1227 (-3.2A)
ANP  A1227 (-3.6A)
 0.42A 3si7B-2chgA:
6.0		 3si7B-2chgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 9 ALA A 207
ALA A 188
GLY A 185
ILE A 190
ILE A 192
 None
 1.15A 4eatB-2chgA:
undetectable		 4eatB-2chgA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 7 GLU A  91
ILE A  89
ILE A  72
MET A  74
 None
 0.98A 4xumA-2chgA:
undetectable		 4xumA-2chgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 1.15A 4xumB-2chgA:
undetectable		 4xumB-2chgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 GLY A  64
GLU A  65
PHE A  63
ILE A  56
 None
 0.92A 5kmfA-2chgA:
undetectable
5kmfC-2chgA:
undetectable		 5kmfA-2chgA:
18.15
5kmfC-2chgA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  86
LYS A  90
TYR A 129
 None
 1.02A 6gnaA-2chgA:
undetectable		 6gnaA-2chgA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2chg REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		3 / 3 ARG A  86
LYS A  90
TYR A 129
 None
 1.02A 6gnbA-2chgA:
undetectable		 6gnbA-2chgA:
24.91