SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2chp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HK2_A_T44A3002_1 (SERUM ALBUMIN)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	4 / 8	GLN A 102 LEU A 148 LEU A 46 SER A 96	None	1.25A	1hk2A-2chpA: undetectable	1hk2A-2chpA: 13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U72_A_MTXA188_1 (DIHYDROFOLATE REDUCTASE)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	5 / 12	ALA A 57 LEU A 31 GLN A 110 ASN A 106 VAL A 141	None	1.17A	1u72A-2chpA: undetectable	1u72A-2chpA: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1100_1 (SERUM ALBUMIN)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	4 / 4	LEU A 148 ARG A 33 LEU A 31 ALA A 103	None	1.06A	3b9mA-2chpA: 2.1	3b9mA-2chpA: 13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWJ_A_30ZA201_1 (TRANSTHYRETIN)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	4 / 6	LYS A 49 LEU A 53 THR A 45 LEU A 31	None	1.04A	4pwjA-2chpA: undetectable	4pwjA-2chpA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QC6_B_KANB201_2 (BIFUNCTIONAL AAC/APH)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	3 / 3	LEU A 104 ASP A 107 TYR A 108	None	0.39A	4qc6B-2chpA: undetectable	4qc6B-2chpA: 25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XI3_D_29SD601_1 (ESTROGEN RECEPTOR)	2chp	METALLOREGULATION DNA-BINDING STRESS PROTEIN (Bacillus subtilis)	5 / 12	THR A 60 ALA A 57 LEU A 53 LEU A 27 LEU A 26	None	1.27A	4xi3D-2chpA: undetectable	4xi3D-2chpA: 20.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HK2_A_T44A3002_1","SERUM ALBUMIN","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",4,"GLN A 102;LEU A 148;LEU A  46;SER A  96","None","1.25A","1hk2A-2chpA:undetectable","1hk2A-2chpA:13.36"],["1U72_A_MTXA188_1","DIHYDROFOLATE REDUCTASE","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",5,"ALA A  57;LEU A  31;GLN A 110;ASN A 106;VAL A 141","None","1.17A","1u72A-2chpA:undetectable","1u72A-2chpA:23.16"],["3B9M_A_SALA1100_1","SERUM ALBUMIN","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",4,"LEU A 148;ARG A  33;LEU A  31;ALA A 103","None","1.06A","3b9mA-2chpA:2.1","3b9mA-2chpA:13.18"],["4PWJ_A_30ZA201_1","TRANSTHYRETIN","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",4,"LYS A  49;LEU A  53;THR A  45;LEU A  31","None","1.04A","4pwjA-2chpA:undetectable","4pwjA-2chpA:18.52"],["4QC6_B_KANB201_2","BIFUNCTIONAL AAC\/APH","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",3,"LEU A 104;ASP A 107;TYR A 108","None","0.39A","4qc6B-2chpA:undetectable","4qc6B-2chpA:25.67"],["4XI3_D_29SD601_1","ESTROGEN RECEPTOR","2chp","METALLOREGULATION DNA-BINDING STRESS PROTEIN","Bacillus subtilis",5,"THR A  60;ALA A  57;LEU A  53;LEU A  27;LEU A  26","None","1.27A","4xi3D-2chpA:undetectable","4xi3D-2chpA:20.75"]]