SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2chq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.98A 1mt1A-2chqA:
undetectable
1mt1F-2chqA:
undetectable		 1mt1A-2chqA:
10.19
1mt1F-2chqA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 ILE A  26
GLU A  34
ASP A  61
LEU A  58
 None
 0.92A 1mt1B-2chqA:
undetectable
1mt1C-2chqA:
undetectable		 1mt1B-2chqA:
16.88
1mt1C-2chqA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 7 ASP A  61
LEU A  58
ILE A  26
GLU A  34
 None
 0.99A 1n13I-2chqA:
undetectable
1n13L-2chqA:
undetectable		 1n13I-2chqA:
10.19
1n13L-2chqA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 11 MET A 231
THR A 225
GLY A 258
GLU A 256
GLU A 230
 None
 1.28A 1odiE-2chqA:
undetectable		 1odiE-2chqA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 271
GLU A 229
TYR A 191
TYR A 257
 None
 0.78A 1qvtA-2chqA:
3.0		 1qvtA-2chqA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 289
MET A 254
MET A 259
LEU A 296
MET A 231
 None
 1.39A 1sqnA-2chqA:
undetectable		 1sqnA-2chqA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 157
GLY A  45
PRO A  46
 None
 0.76A 2hreD-2chqA:
undetectable		 2hreD-2chqA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 1.03A 3adsB-2chqA:
undetectable		 3adsB-2chqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 MET A 254
GLU A 302
LEU A 306
GLN A 305
LEU A 289
 None
 1.44A 3ia4A-2chqA:
undetectable		 3ia4A-2chqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 THR A  49
GLY A  21
ALA A 165
ILE A 190
 ANP  A 700 (-4.9A)
None
None
None
 0.74A 3jusA-2chqA:
undetectable		 3jusA-2chqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 THR A  49
GLY A  21
ALA A 165
ILE A 190
 ANP  A 700 (-4.9A)
None
None
None
 0.74A 3jusA-2chqA:
undetectable		 3jusA-2chqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 8 THR A  49
GLY A  21
ALA A 165
ILE A 190
 ANP  A 700 (-4.9A)
None
None
None
 0.80A 3jusB-2chqA:
undetectable		 3jusB-2chqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 200
SER A 193
ILE A 190
LEU A 186
GLY A 185
 None
 1.12A 3k2hA-2chqA:
undetectable		 3k2hA-2chqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 200
SER A 193
ILE A 190
LEU A 186
GLY A 185
 None
 1.12A 3k2hB-2chqA:
undetectable		 3k2hB-2chqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 197
GLY A  21
ALA A 165
ILE A 190
ILE A 192
 ANP  A 700 (-4.0A)
None
None
None
None
 1.12A 3ld6A-2chqA:
undetectable		 3ld6A-2chqA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 226
PRO A 228
GLU A 233
LEU A 253
 None
 1.03A 4iomA-2chqA:
undetectable		 4iomA-2chqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 289
LEU A 239
MET A 231
LEU A 310
 None
 0.96A 4okwA-2chqA:
undetectable		 4okwA-2chqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 206
GLN A 205
ALA A 207
VAL A 214
LEU A 189
 None
 1.05A 4pd5A-2chqA:
undetectable		 4pd5A-2chqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 206
ALA A 207
VAL A 214
LEU A 189
ILE A 201
 None
None
None
None
ANP  A 700 ( 4.9A)
 1.05A 4pd9A-2chqA:
undetectable		 4pd9A-2chqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 206
GLN A 205
ALA A 207
VAL A 214
LEU A 189
 None
 1.03A 4pd9A-2chqA:
undetectable		 4pd9A-2chqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 268
LEU A 250
ALA A 311
LEU A 310
TYR A 309
 None
 1.22A 4wg0H-2chqA:
undetectable
4wg0I-2chqA:
undetectable
4wg0J-2chqA:
undetectable		 4wg0H-2chqA:
4.64
4wg0I-2chqA:
4.64
4wg0J-2chqA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 311
LEU A 310
TYR A 309
LEU A 250
LEU A 268
 None
 1.20A 4wg0I-2chqA:
undetectable
4wg0J-2chqA:
undetectable
4wg0K-2chqA:
undetectable		 4wg0I-2chqA:
4.64
4wg0J-2chqA:
4.64
4wg0K-2chqA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		4 / 6 PRO A  13
ILE A  26
VAL A 161
PHE A 158
 ANP  A 700 (-4.0A)
None
None
None
 1.14A 4xe5A-2chqA:
2.4		 4xe5A-2chqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 0.98A 4xumB-2chqA:
undetectable		 4xumB-2chqA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 245
LEU A 310
LEU A 313
ILE A 235
GLU A 233
 None
 1.22A 5v0vA-2chqA:
3.3		 5v0vA-2chqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2chq REPLICATION FACTOR C
SMALL SUBUNIT
(Archaeoglobus
fulgidus) 		5 / 9 ALA A 226
GLU A 230
LEU A 253
MET A 254
GLY A 261
 None
 1.47A 5wgqA-2chqA:
undetectable		 5wgqA-2chqA:
15.67