SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2chr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 8 ILE A   6
LEU A  75
GLU A 105
ALA A 107
VAL A  36
 None
 1.25A 1a29A-2chrA:
undetectable		 1a29A-2chrA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 7 GLN A 197
ASP A 245
LEU A 299
SER A  22
 None
MN  A 400 ( 3.1A)
None
None
 1.12A 1ig3A-2chrA:
undetectable
1ig3B-2chrA:
undetectable		 1ig3A-2chrA:
22.28
1ig3B-2chrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A  75
ALA A  72
LEU A  71
VAL A  34
ALA A   8
 None
 1.16A 1sa1A-2chrA:
3.2
1sa1B-2chrA:
3.1		 1sa1A-2chrA:
23.01
1sa1B-2chrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A  75
ALA A  72
LEU A  71
VAL A  34
ALA A   8
 None
 1.14A 1sa1C-2chrA:
undetectable
1sa1D-2chrA:
3.3		 1sa1C-2chrA:
23.01
1sa1D-2chrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 SER A 262
LEU A 268
GLY A 290
VAL A 285
ALA A 284
 None
 1.08A 1tlsA-2chrA:
undetectable		 1tlsA-2chrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 SER A 262
LEU A 268
GLY A 290
VAL A 285
ALA A 284
 None
 1.08A 1tlsB-2chrA:
undetectable		 1tlsB-2chrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		3 / 3 GLU A 337
GLU A 340
LEU A 309
 None
 0.75A 1v8bB-2chrA:
undetectable		 1v8bB-2chrA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		3 / 3 LYS A 163
ASP A 300
CYH A 271
 CL  A 500 ( 3.8A)
None
None
 1.34A 2br4F-2chrA:
undetectable		 2br4F-2chrA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 311
VAL A 315
ALA A 102
SER A 267
GLY A 296
 None
 1.18A 2vmyB-2chrA:
undetectable		 2vmyB-2chrA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		3 / 3 TYR A 294
GLU A 220
THR A 137
 None
MN  A 400 (-2.9A)
None
 1.03A 2y7hB-2chrA:
undetectable		 2y7hB-2chrA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 7 VAL A  26
THR A  15
LEU A 330
TRP A 136
 None
 1.19A 3arrA-2chrA:
5.6		 3arrA-2chrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 7 LYS A 269
LEU A 248
ASP A 245
SER A 253
 CL  A 500 (-3.3A)
None
MN  A 400 ( 3.1A)
None
 1.42A 3dzgA-2chrA:
undetectable		 3dzgA-2chrA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 218
GLY A 321
PRO A 133
SER A 313
ALA A 292
 None
 1.14A 3i5uB-2chrA:
undetectable		 3i5uB-2chrA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 8 SER A  38
ASP A  79
VAL A  83
LEU A 109
 None
 1.13A 3jq7C-2chrA:
undetectable		 3jq7C-2chrA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 8 LEU A 175
VAL A 216
ILE A 219
VAL A 193
LEU A 166
 None
 1.25A 3kp6A-2chrA:
undetectable
3kp6B-2chrA:
undetectable		 3kp6A-2chrA:
18.63
3kp6B-2chrA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		3 / 3 GLY A  47
ILE A  66
VAL A  67
 None
 0.42A 3nv6A-2chrA:
undetectable		 3nv6A-2chrA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 7 LEU A 218
VAL A 265
LEU A 257
ASP A 245
 None
None
None
MN  A 400 ( 3.1A)
 0.88A 3rgfA-2chrA:
undetectable		 3rgfA-2chrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 7 ILE A 303
GLY A 304
SER A 301
LEU A 339
 None
 0.87A 3v7pA-2chrA:
6.4		 3v7pA-2chrA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 8 THR A  62
GLY A  48
GLY A  47
VAL A  32
 None
 0.83A 4qvvK-2chrA:
undetectable
4qvvL-2chrA:
undetectable		 4qvvK-2chrA:
20.28
4qvvL-2chrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 8 THR A  62
GLY A  48
GLY A  47
VAL A  32
 None
 0.83A 4qvvY-2chrA:
undetectable
4qvvZ-2chrA:
undetectable		 4qvvY-2chrA:
20.28
4qvvZ-2chrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 8 LEU A 108
ALA A  80
MET A   1
ILE A   3
 None
 0.74A 4wboB-2chrA:
undetectable		 4wboB-2chrA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		4 / 5 LEU A 324
PHE A 328
ILE A 134
ILE A 341
 None
 0.98A 5dzk4-2chrA:
undetectable
5dzkg-2chrA:
1.7
5dzkm-2chrA:
2.0
5dzkn-2chrA:
undetectable		 5dzk4-2chrA:
2.63
5dzkg-2chrA:
21.66
5dzkm-2chrA:
21.20
5dzkn-2chrA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 309
GLY A 295
GLU A 323
GLU A  46
GLY A  48
 None
 1.28A 5f9zA-2chrA:
undetectable		 5f9zA-2chrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 9 ILE A 120
GLY A 355
GLN A 280
LEU A 309
LEU A 339
 None
 1.39A 5fhzB-2chrA:
undetectable		 5fhzB-2chrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 10 ILE A 120
GLY A 355
GLN A 280
LEU A 309
LEU A 339
 None
 1.32A 5fhzC-2chrA:
undetectable		 5fhzC-2chrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 GLU A  58
GLY A 274
ASN A 272
LEU A 248
ALA A 254
 None
 1.13A 5kbwA-2chrA:
undetectable		 5kbwA-2chrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 GLU A  58
GLY A 274
ASN A 272
LEU A 248
ALA A 254
 None
 1.26A 5kc4E-2chrA:
undetectable		 5kc4E-2chrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 334
VAL A  44
GLY A  45
GLY A 304
TYR A  31
 None
 1.23A 5nnaB-2chrA:
1.3		 5nnaB-2chrA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		5 / 12 LEU A 334
VAL A  44
GLY A  45
GLY A 304
TYR A  31
 None
 1.20A 5nnaC-2chrA:
undetectable		 5nnaC-2chrA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2chr CHLOROMUCONATE
CYCLOISOMERASE
(Cupriavidus
necator) 		3 / 3 LEU A 309
ALA A 308
LEU A 339
 None
 0.40A 5uunB-2chrA:
undetectable		 5uunB-2chrA:
24.29