SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ci6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 11 THR A  90
LEU A 125
VAL A 130
GLY A 128
VAL A 276
 None
None
None
ZN  A1281 ( 4.0A)
None
 1.26A 2a1nA-2ci6A:
undetectable		 2a1nA-2ci6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 5 LEU A 264
ASN A 261
VAL A  37
ALA A  42
 None
 1.19A 2cizA-2ci6A:
0.0		 2cizA-2ci6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 9 ILE A 199
ASP A 129
LEU A 173
GLY A 140
THR A 133
 None
 1.32A 2tsrD-2ci6A:
undetectable		 2tsrD-2ci6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 11 LEU A  59
HIS A  14
LEU A 111
LEU A 224
VAL A  82
 None
 1.17A 2uxoB-2ci6A:
undetectable		 2uxoB-2ci6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 ASP A 253
LEU A 211
LEU A 184
GLY A 181
HIS A 254
 None
 1.49A 2zj0C-2ci6A:
undetectable		 2zj0C-2ci6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 7 LEU A  59
ARG A  11
GLY A 230
MET A 255
 None
 1.05A 3hcrB-2ci6A:
undetectable		 3hcrB-2ci6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 10 THR A 156
GLY A 149
THR A 145
VAL A 130
VAL A 139
 None
 1.31A 3lxiA-2ci6A:
undetectable		 3lxiA-2ci6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 5 GLN A  60
THR A  13
LEU A 108
LEU A 111
 None
 0.91A 4lvcB-2ci6A:
undetectable		 4lvcB-2ci6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 5 VAL A  16
LEU A 108
ILE A 278
LEU A 277
 None
 0.85A 4mghA-2ci6A:
undetectable		 4mghA-2ci6A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 5 ASN A 146
GLY A 149
ASP A 102
ASP A 120
 None
 1.12A 4n48B-2ci6A:
undetectable		 4n48B-2ci6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 9 GLY A  51
VAL A  17
SER A 275
VAL A  15
LEU A 277
 None
 0.83A 4qd3A-2ci6A:
undetectable		 4qd3A-2ci6A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 SER A 175
ALA A 193
LEU A 197
THR A 133
ALA A 219
 None
 1.18A 4x1kA-2ci6A:
undetectable
4x1kB-2ci6A:
undetectable		 4x1kA-2ci6A:
21.94
4x1kB-2ci6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		6 / 12 VAL A  76
ASP A  78
GLU A 100
PRO A  71
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
None
 1.49A 5m50B-2ci6A:
undetectable		 5m50B-2ci6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 VAL A  76
ASP A  78
GLU A 100
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
 0.99A 5m54B-2ci6A:
undetectable		 5m54B-2ci6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 VAL A  76
ASP A  78
GLU A 100
ARG A  97
LEU A  24
 None
ZN  A1281 ( 4.1A)
None
None
None
 1.02A 5m5cB-2ci6A:
undetectable		 5m5cB-2ci6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		4 / 4 GLN A  60
THR A  13
LEU A 108
LEU A 111
 None
 0.90A 5m5kB-2ci6A:
undetectable		 5m5kB-2ci6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 GLY A 140
ASP A 129
ASP A 126
ALA A 150
LEU A 141
 None
 1.00A 6bq4A-2ci6A:
undetectable		 6bq4A-2ci6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 GLY A 140
ASP A 129
ASP A 126
ALA A 150
LEU A 141
 None
 1.01A 6bq4B-2ci6A:
undetectable		 6bq4B-2ci6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1
(Bos
taurus) 		5 / 12 ASP A 253
LEU A 211
LEU A 184
GLY A 181
HIS A 254
 None
 1.45A 6f3nC-2ci6A:
undetectable		 6f3nC-2ci6A:
22.50