SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		5 / 12 LEU A  50
LEU A 168
LEU A 163
GLY A 162
PHE A  54
 None
 1.45A 1d4fD-2cicA:
undetectable		 1d4fD-2cicA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 GLU A 223
TYR A 226
PHE A 181
 None
 0.95A 1eqbB-2cicA:
undetectable		 1eqbB-2cicA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 GLU A 223
TYR A 226
PHE A 181
 None
 0.95A 1eqbA-2cicA:
undetectable		 1eqbA-2cicA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 GLU A 223
TYR A 226
PHE A 181
 None
 0.94A 1eqbD-2cicA:
undetectable		 1eqbD-2cicA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 GLU A 223
TYR A 226
PHE A 181
 None
 0.95A 1eqbC-2cicA:
undetectable		 1eqbC-2cicA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 ASN A  22
TRP A  26
GLN A 183
 DUP  A1968 (-3.1A)
None
None
 1.12A 1xoqA-2cicA:
undetectable		 1xoqA-2cicA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 LEU A 151
GLU A 104
ILE A 101
 None
 0.53A 3czhA-2cicA:
undetectable		 3czhA-2cicA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		3 / 3 SER A 109
GLN A 112
PHE A 111
 None
 0.80A 3g4lC-2cicA:
undetectable		 3g4lC-2cicA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		4 / 6 ILE A  73
ASP A  77
VAL A 177
HIS A  80
 None
MG  A1970 ( 3.2A)
None
DUP  A1968 (-3.7A)
 0.97A 4oltB-2cicA:
undetectable		 4oltB-2cicA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		5 / 12 ASP A 132
LEU A 157
LEU A  50
LEU A 130
ILE A 133
 None
 1.02A 4x1fA-2cicA:
undetectable		 4x1fA-2cicA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE
(Campylobacter
jejuni) 		5 / 12 ASP A 132
LEU A 157
LEU A  50
LEU A 130
ILE A 133
 None
 1.06A 4x1gA-2cicA:
undetectable		 4x1gA-2cicA:
19.25