SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 274
LEU A 126
VAL A 143
PHE A 154
THR A 146
 None
 1.09A 3frbX-2cirA:
undetectable		 3frbX-2cirA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  24
LEU A 128
GLY A  58
GLY A  59
LEU A  62
 None
 1.07A 3uq6A-2cirA:
undetectable		 3uq6A-2cirA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		4 / 8 GLN A  81
ARG A  86
HIS A  82
ARG A  57
 BG6  A 501 (-3.8A)
BG6  A 501 (-3.0A)
BG6  A 501 (-4.2A)
BG6  A 501 (-2.9A)
 1.16A 3uy4A-2cirA:
undetectable		 3uy4A-2cirA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  24
LEU A 128
GLY A  58
GLY A  59
LEU A  62
 None
 1.07A 3vasB-2cirA:
undetectable		 3vasB-2cirA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  22
SER A 134
LEU A 285
GLY A 133
ASP A 135
 None
None
CSO  A 287 ( 4.5A)
None
None
 1.29A 4pevC-2cirA:
undetectable		 4pevC-2cirA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 256
LEU A  44
ALA A  48
ASP A 250
ALA A 249
 None
 1.23A 4wnuD-2cirA:
undetectable		 4wnuD-2cirA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 126
TYR A 124
ALA A 112
ILE A 111
 None
 1.09A 4y03B-2cirA:
undetectable		 4y03B-2cirA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 219
VAL A 195
ILE A 261
ILE A 164
ILE A 167
 None
 1.30A 5hw8B-2cirA:
undetectable		 5hw8B-2cirA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 267
ASP A 234
HIS A 269
 None
 0.91A 5n1tW-2cirA:
undetectable		 5n1tW-2cirA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 105
THR A  89
ASP A   7
GLU A   5
 None
 1.42A 5ybbA-2cirA:
undetectable		 5ybbA-2cirA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		4 / 6 SER A 210
THR A 235
ILE A 263
PHE A 162
 None
 0.90A 6f8cA-2cirA:
undetectable		 6f8cA-2cirA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  54
TYR A  27
 BG6  A 501 (-3.0A)
None
None
 1.15A 6gnaA-2cirA:
undetectable		 6gnaA-2cirA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2cir HEXOSE-6-PHOSPHATE
MUTAROTASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  86
LYS A  54
TYR A  27
 BG6  A 501 (-3.0A)
None
None
 1.15A 6gnbA-2cirA:
undetectable		 6gnbA-2cirA:
23.49