SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ILE A  11
LEU A   9
VAL A 250
ALA A 212
 None
 0.90A 1mz9A-2citA:
undetectable		 1mz9A-2citA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ILE A  11
LEU A   9
VAL A 250
ALA A 212
 None
 0.85A 1mz9C-2citA:
undetectable		 1mz9C-2citA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 188
GLY A 229
GLY A 230
SER A 225
 None
 0.50A 1qzzA-2citA:
undetectable		 1qzzA-2citA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A 147
PHE A 142
ASN A 149
ILE A 102
 None
 1.17A 1yc2D-2citA:
undetectable		 1yc2D-2citA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A 142
VAL A 150
TRP A 152
 None
 0.72A 2cc8A-2citA:
undetectable		 2cc8A-2citA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A 142
VAL A 150
TRP A 152
 None
 0.72A 2ccbA-2citA:
undetectable		 2ccbA-2citA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 PHE A 142
VAL A 150
TRP A 152
 None
 0.73A 2vx9A-2citA:
undetectable		 2vx9A-2citA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 184
VAL A 156
LEU A 211
ILE A 243
PHE A 200
 None
 1.00A 3mnoA-2citA:
undetectable		 3mnoA-2citA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 184
VAL A 156
LEU A 211
ILE A 243
PHE A 200
 None
 0.99A 3mnpA-2citA:
undetectable		 3mnpA-2citA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 166
ASN A 128
ILE A 119
ASN A 160
 None
 1.04A 4d33A-2citA:
undetectable		 4d33A-2citA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 7 SER A 166
ASN A 128
ILE A 119
ASN A 160
 None
 1.04A 4d33B-2citA:
undetectable		 4d33B-2citA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 166
ASN A 128
ILE A 119
ASN A 160
 None
 1.09A 4d39A-2citA:
undetectable		 4d39A-2citA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		5 / 10 PHE A 142
VAL A 150
LEU A  65
LEU A 104
PHE A  48
 None
 1.31A 4zmeB-2citA:
undetectable		 4zmeB-2citA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN A 126
SER A 123
SER A 122
 None
 0.74A 5gsnA-2citA:
undetectable		 5gsnA-2citA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 6 LYS A 100
SER A  49
VAL A  51
ASP A  56
 None
 1.29A 5hesA-2citA:
undetectable		 5hesA-2citA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2cit ENDOGLUCANASE H
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLU A 222
ARG A 105
ALA A 109
TYR A 185
 G2F  A1283 (-1.8A)
None
None
G2F  A1283 (-3.8A)
 1.09A 5phhA-2citA:
undetectable		 5phhA-2citA:
20.63