SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 8 GLY A 463
VAL A 464
GLU A 467
ILE A 356
 None
 0.86A 1pk7B-2cjaA:
undetectable		 1pk7B-2cjaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 6 PRO A 422
HIS A 179
PHE A 380
LEU A 384
 None
 1.14A 1sbrA-2cjaA:
undetectable
1sbrB-2cjaA:
4.1		 1sbrA-2cjaA:
18.78
1sbrB-2cjaA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 5 LEU A 111
PRO A 106
ALA A 107
ILE A 129
 None
 0.98A 2aofB-2cjaA:
undetectable		 2aofB-2cjaA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 12 LEU A 152
ASP A 108
GLY A 127
ILE A 125
ILE A 156
 None
 0.95A 2r5pA-2cjaA:
undetectable		 2r5pA-2cjaA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 12 LEU A 152
ASP A 108
GLY A 127
ILE A 125
ILE A 156
 None
 0.96A 2r5pC-2cjaA:
undetectable		 2r5pC-2cjaA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		3 / 3 ARG A 143
ARG A 147
PRO A 145
 None
 0.74A 2wljA-2cjaA:
undetectable		 2wljA-2cjaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 11 LEU A 133
GLY A 136
VAL A  98
ILE A 119
GLU A 139
 None
 1.08A 2yy8A-2cjaA:
undetectable
2yy8B-2cjaA:
undetectable		 2yy8A-2cjaA:
15.90
2yy8B-2cjaA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 8 HIS A 206
THR A 186
HIS A 352
LEU A 421
 None
 1.21A 3asoA-2cjaA:
undetectable
3asoC-2cjaA:
undetectable
3asoP-2cjaA:
undetectable		 3asoA-2cjaA:
21.72
3asoC-2cjaA:
19.39
3asoP-2cjaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 4 ILE A  24
GLN A  80
ILE A  91
LEU A  36
 None
 1.09A 3dzyD-2cjaA:
undetectable		 3dzyD-2cjaA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		3 / 3 GLY A 465
ILE A 220
VAL A 221
 ATP  A1505 (-3.3A)
None
None
 0.51A 3nv6A-2cjaA:
undetectable		 3nv6A-2cjaA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 6 GLU A 316
TRP A 310
PRO A 444
GLY A 315
 None
 1.09A 3oxvA-2cjaA:
undetectable		 3oxvA-2cjaA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 9 LEU A 152
ASP A 108
GLY A 127
ILE A 125
ILE A 156
 None
 1.01A 3s56B-2cjaA:
undetectable		 3s56B-2cjaA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 7 THR A 414
ASN A 439
HIS A 373
ILE A 438
 None
 1.09A 3t01A-2cjaA:
undetectable		 3t01A-2cjaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 8 ILE A 102
GLU A 132
GLN A 130
ILE A 129
 None
 0.83A 4mj8A-2cjaA:
undetectable		 4mj8A-2cjaA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 6 LEU A 111
GLU A 110
ASN A 124
ILE A 129
 None
 0.94A 4ww7A-2cjaA:
undetectable		 4ww7A-2cjaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 5 ASP A 184
THR A 186
GLN A 187
GLU A 346
 None
 1.23A 5k9dA-2cjaA:
0.0		 5k9dA-2cjaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 11 LEU A 152
ASP A 108
GLY A 127
ILE A 125
ILE A 156
 None
 0.98A 5kr2B-2cjaA:
undetectable		 5kr2B-2cjaA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 8 ARG A 468
PHE A 433
ASN A 435
ASP A 416
 ATP  A1505 (-3.9A)
None
ATP  A1505 (-4.2A)
None
 1.34A 5vunB-2cjaA:
undetectable		 5vunB-2cjaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 10 ARG A 336
GLU A 338
PHE A 351
GLU A 432
ARG A 468
 ATP  A1505 (-2.9A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.4A)
ATP  A1505 (-2.9A)
ATP  A1505 (-3.9A)
 0.96A 6bniA-2cjaA:
9.6		 6bniA-2cjaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 10 ARG A 336
GLU A 338
PHE A 351
GLY A 465
ARG A 468
 ATP  A1505 (-2.9A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.4A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.9A)
 0.93A 6bniA-2cjaA:
9.6		 6bniA-2cjaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 10 ARG A 336
GLU A 338
PHE A 351
GLU A 432
ARG A 468
 ATP  A1505 (-2.9A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.4A)
ATP  A1505 (-2.9A)
ATP  A1505 (-3.9A)
 0.95A 6bniB-2cjaA:
10.5		 6bniB-2cjaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		5 / 10 ARG A 336
GLU A 338
PHE A 351
GLY A 465
ARG A 468
 ATP  A1505 (-2.9A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.4A)
ATP  A1505 (-3.3A)
ATP  A1505 (-3.9A)
 0.93A 6bniB-2cjaA:
10.5		 6bniB-2cjaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2cja SERYL-TRNA
SYNTHETASE
(Methanosarcina
barkeri) 		4 / 7 HIS A 335
THR A 333
ARG A 201
ASP A 349
 None
 0.88A 6mn4E-2cjaA:
undetectable		 6mn4E-2cjaA:
18.57