SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cjk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CKK_A_SAMA301_0 (TRNA (GUANINE-N(7)-)-METH YLTRANSFERASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 12	GLY A 164 GLY A 201 LEU A 223 ASP A 277 THR A 170	U B 5 ( 2.4A) A B 4 ( 3.0A) None A B 4 ( 2.5A) None	1.05A	3ckkA-2cjkA: undetectable	3ckkA-2cjkA: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_A_NCAA192_0 (NICOTINAMIDASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 11	ASP A 224 LEU A 175 PHE A 179 LEU A 166 ILE A 228	None	1.14A	3o94A-2cjkA: undetectable	3o94A-2cjkA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_B_NCAB192_0 (NICOTINAMIDASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 11	ASP A 224 LEU A 175 PHE A 179 LEU A 166 ILE A 228	None	1.17A	3o94B-2cjkA: undetectable	3o94B-2cjkA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_C_NCAC192_0 (NICOTINAMIDASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 11	ASP A 224 LEU A 175 PHE A 179 LEU A 166 ILE A 228	None	1.14A	3o94C-2cjkA: undetectable	3o94C-2cjkA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3O94_D_NCAD192_0 (NICOTINAMIDASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 11	ASP A 224 LEU A 175 PHE A 179 LEU A 166 ILE A 228	None	1.14A	3o94D-2cjkA: undetectable	3o94D-2cjkA: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I75_A_68PA701_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 12	ILE A 245 ALA A 318 GLY A 267 GLY A 243 VAL A 300	None A B 2 ( 4.2A) None None None	1.08A	5i75A-2cjkA: undetectable	5i75A-2cjkA: 14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_D_D16D402_1 (THYMIDYLATE SYNTHASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 8	ARG A 198 LEU A 166 GLY A 164 PHE A 202 TYR A 178	None None U B 5 ( 2.4A) U B 5 ( 3.0A) None	1.47A	5nooD-2cjkA: undetectable	5nooD-2cjkA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VEU_A_RITA602_2 (CYTOCHROME P450 3A5)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	3 / 3	ARG A 176 PHE A 202 LEU A 223	None U B 5 ( 3.0A) None	0.82A	5veuA-2cjkA: undetectable	5veuA-2cjkA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	7DFR_A_FOLA161_0 (DIHYDROFOLATE REDUCTASE)	2cjk	NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4 (Saccharomyces cerevisiae)	5 / 12	ILE A 245 ALA A 296 PHE A 263 ILE A 306 ILE A 315	None	1.06A	7dfrA-2cjkA: undetectable	7dfrA-2cjkA: 25.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3CKK_A_SAMA301_0","TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"GLY A 164;GLY A 201;LEU A 223;ASP A 277;THR A 170","  U B   5 ( 2.4A);  A B   4 ( 3.0A);None;  A B   4 ( 2.5A);None","1.05A","3ckkA-2cjkA:undetectable","3ckkA-2cjkA:18.22"],["3O94_A_NCAA192_0","NICOTINAMIDASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ASP A 224;LEU A 175;PHE A 179;LEU A 166;ILE A 228","None","1.14A","3o94A-2cjkA:undetectable","3o94A-2cjkA:18.75"],["3O94_B_NCAB192_0","NICOTINAMIDASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ASP A 224;LEU A 175;PHE A 179;LEU A 166;ILE A 228","None","1.17A","3o94B-2cjkA:undetectable","3o94B-2cjkA:18.75"],["3O94_C_NCAC192_0","NICOTINAMIDASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ASP A 224;LEU A 175;PHE A 179;LEU A 166;ILE A 228","None","1.14A","3o94C-2cjkA:undetectable","3o94C-2cjkA:18.75"],["3O94_D_NCAD192_0","NICOTINAMIDASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ASP A 224;LEU A 175;PHE A 179;LEU A 166;ILE A 228","None","1.14A","3o94D-2cjkA:undetectable","3o94D-2cjkA:18.75"],["5I75_A_68PA701_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ILE A 245;ALA A 318;GLY A 267;GLY A 243;VAL A 300","None;  A B   2 ( 4.2A);None;None;None","1.08A","5i75A-2cjkA:undetectable","5i75A-2cjkA:14.13"],["5NOO_D_D16D402_1","THYMIDYLATE SYNTHASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ARG A 198;LEU A 166;GLY A 164;PHE A 202;TYR A 178","None;None;  U B   5 ( 2.4A);  U B   5 ( 3.0A);None","1.47A","5nooD-2cjkA:undetectable","5nooD-2cjkA:18.79"],["5VEU_A_RITA602_2","CYTOCHROME P450 3A5","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",3,"ARG A 176;PHE A 202;LEU A 223","None;  U B   5 ( 3.0A);None","0.82A","5veuA-2cjkA:undetectable","5veuA-2cjkA:18.97"],["7DFR_A_FOLA161_0","DIHYDROFOLATE REDUCTASE","2cjk","NUCLEAR POLYADENYLATED RNA-BINDING PROTEIN 4","Saccharomyces cerevisiae",5,"ILE A 245;ALA A 296;PHE A 263;ILE A 306;ILE A 315","None","1.06A","7dfrA-2cjkA:undetectable","7dfrA-2cjkA:25.13"]]