SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 THR A 573
PRO A 575
THR A 574
 None
 0.83A 1a7yB-2cjqA:
undetectable		 1a7yB-2cjqA:
1.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 GLN A 308
TYR A 369
ARG A 370
 None
 0.94A 1gtbA-2cjqA:
undetectable		 1gtbA-2cjqA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 8 GLY A 362
ILE A 361
ILE A 298
ILE A 380
 None
 0.72A 1hshD-2cjqA:
undetectable		 1hshD-2cjqA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 GLY A 404
GLN A 407
LEU A 358
LEU A 417
THR A 346
 None
 1.15A 1p93C-2cjqA:
0.0		 1p93C-2cjqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ASN A 414
TRP A 349
GLN A 407
 None
 1.44A 1xoqA-2cjqA:
undetectable		 1xoqA-2cjqA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 LEU A 669
GLY A 666
ALA A 590
ILE A 595
GLY A 596
 None
 0.74A 2avsA-2cjqA:
undetectable		 2avsA-2cjqA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 LEU A 669
GLY A 666
ALA A 590
ILE A 595
GLY A 596
 None
 0.70A 2avvD-2cjqA:
undetectable		 2avvD-2cjqA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 10 SER A 548
PHE A 547
GLY A 585
THR A 580
TYR A 582
 None
 1.31A 2b8jB-2cjqA:
undetectable		 2b8jB-2cjqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ARG A 561
ASN A 612
THR A 605
 None
 0.69A 2q63A-2cjqA:
undetectable		 2q63A-2cjqA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASN A 614
THR A 627
ILE A 148
THR A 519
LEU A 523
 None
 1.41A 3bexC-2cjqA:
undetectable
3bexD-2cjqA:
undetectable		 3bexC-2cjqA:
16.69
3bexD-2cjqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASN A 614
THR A 627
ILE A 148
THR A 519
LEU A 523
 None
 1.41A 3bf1A-2cjqA:
undetectable
3bf1B-2cjqA:
undetectable		 3bf1A-2cjqA:
16.69
3bf1B-2cjqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASN A 614
THR A 627
ILE A 148
THR A 519
LEU A 523
 None
 1.32A 3bf1C-2cjqA:
undetectable
3bf1D-2cjqA:
undetectable		 3bf1C-2cjqA:
16.69
3bf1D-2cjqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 THR A 519
LEU A 523
ASN A 614
THR A 627
ILE A 148
 None
 1.41A 3bf1C-2cjqA:
undetectable
3bf1D-2cjqA:
undetectable		 3bf1C-2cjqA:
16.69
3bf1D-2cjqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASN A 614
THR A 627
ILE A 148
THR A 519
LEU A 523
 None
 1.41A 3bf1E-2cjqA:
undetectable
3bf1F-2cjqA:
undetectable		 3bf1E-2cjqA:
16.69
3bf1F-2cjqA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 THR A 379
VAL A 241
LEU A 296
ILE A 245
THR A 299
 None
 1.48A 3elzB-2cjqA:
0.0		 3elzB-2cjqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 THR A 379
VAL A 241
LEU A 296
ILE A 245
THR A 299
 None
 1.41A 3elzC-2cjqA:
undetectable		 3elzC-2cjqA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 THR A 480
LYS A 175
GLU A 483
 None
 1.02A 3ijdB-2cjqA:
undetectable		 3ijdB-2cjqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.97A 3sfuA-2cjqA:
23.9		 3sfuA-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
SER A 405
ASN A 414
ASP A 448
ASP A 449
 None
 1.22A 3sfuA-2cjqA:
23.9		 3sfuA-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 9 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.94A 3sfuB-2cjqA:
24.3		 3sfuB-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 ASP A 350
SER A 405
ASN A 414
GLY A 447
ASP A 448
 None
 1.13A 3sfuC-2cjqA:
23.8		 3sfuC-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 GLN A 352
THR A 354
ASN A 178
 None
 0.83A 3v4tE-2cjqA:
undetectable		 3v4tE-2cjqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.16A 3w9tB-2cjqA:
undetectable		 3w9tB-2cjqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.17A 3w9tC-2cjqA:
undetectable		 3w9tC-2cjqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 SER A 415
GLY A 413
TRP A 349
ASP A 350
 None
 1.17A 3w9tD-2cjqA:
undetectable		 3w9tD-2cjqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 ASN A 556
LEU A 599
PHE A 549
 None
 0.81A 4dajB-2cjqA:
undetectable		 4dajB-2cjqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		3 / 3 PHE A 192
VAL A 445
ILE A 443
 None
 0.61A 4emaA-2cjqA:
undetectable		 4emaA-2cjqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 6 GLU A 363
ARG A 359
ASP A 378
ASP A 382
 None
 1.30A 4kcnA-2cjqA:
undetectable		 4kcnA-2cjqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 6 GLU A 363
ARG A 359
ASP A 378
ASP A 382
 None
 1.28A 4kcnB-2cjqA:
undetectable		 4kcnB-2cjqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 10 TYR A 591
PHE A 547
SER A 554
ASP A 593
THR A 668
 None
 1.45A 4mm7A-2cjqA:
0.0		 4mm7A-2cjqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 5 HIS A 444
GLU A 317
VAL A 329
LYS A 328
 None
 1.38A 4p6vB-2cjqA:
undetectable
4p6vE-2cjqA:
undetectable		 4p6vB-2cjqA:
20.33
4p6vE-2cjqA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 GLN A 402
GLU A 177
TYR A 256
LEU A 358
GLU A 258
 None
 1.15A 4pb1A-2cjqA:
undetectable		 4pb1A-2cjqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 GLN A 402
GLU A 177
TYR A 256
LEU A 358
GLU A 258
 None
 1.12A 4pd9A-2cjqA:
undetectable		 4pd9A-2cjqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 4 ASN A 117
VAL A 104
THR A 391
ILE A 390
 None
 1.47A 4retA-2cjqA:
undetectable		 4retA-2cjqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 4 ASN A 117
VAL A 104
THR A 391
ILE A 390
 None
 1.47A 4retC-2cjqA:
undetectable		 4retC-2cjqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		4 / 7 ILE A 148
GLY A 147
LEU A 652
ASP A 634
 None
 0.80A 5hieB-2cjqA:
undetectable		 5hieB-2cjqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 11 LEU A 358
LEU A 417
MET A 416
ARG A 403
LEU A 189
 None
 1.32A 5hyrB-2cjqA:
undetectable		 5hyrB-2cjqA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 12 PHE A 192
VAL A 419
PRO A 314
THR A 203
SER A 199
 None
 1.47A 5xioA-2cjqA:
undetectable		 5xioA-2cjqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2cjq RNA-DIRECTED RNA
POLYMERASE
(Pestivirus
A) 		5 / 10 LEU A 358
LEU A 417
MET A 416
ARG A 403
LEU A 189
 None
 1.27A 6cbzB-2cjqA:
undetectable		 6cbzB-2cjqA:
8.19