SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 12 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.28A 1q23B-2cjsC:
undetectable		 1q23B-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 10 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.33A 1q23E-2cjsC:
undetectable		 1q23E-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 11 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.27A 1q23I-2cjsC:
undetectable		 1q23I-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 10 THR C  98
PHE A  49
LEU A  60
VAL A  62
VAL A   6
 ZN  C 201 ( 4.7A)
None
None
None
None
 1.30A 1q23K-2cjsC:
undetectable		 1q23K-2cjsC:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		4 / 7 PHE A  49
LEU A  26
LEU A  60
GLU A  46
 None
None
None
EDO  A1156 (-3.8A)
 1.04A 2jn3A-2cjsA:
undetectable		 2jn3A-2cjsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2cjs UNC-13 HOMOLOG A
REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 11 ALA C 117
SER A   2
GLU A  52
GLY C 105
VAL C 130
 None
EDO  A1155 (-3.3A)
EDO  A1155 (-3.6A)
EDO  A1155 (-3.5A)
GOL  C1145 (-4.7A)
 1.14A 2uxpB-2cjsC:
undetectable		 2uxpB-2cjsC:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		4 / 8 VAL A   8
VAL A  78
LEU A  99
VAL A  62
 None
 0.84A 2zujA-2cjsA:
undetectable		 2zujA-2cjsA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		4 / 6 THR A  22
ASN A  66
GLY A  68
ASP A  72
 None
None
None
GOL  A1158 ( 4.1A)
 1.19A 3w9tE-2cjsA:
undetectable		 3w9tE-2cjsA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 12 PHE A  49
VAL A   8
ILE A 121
ILE A  53
VAL A  64
 None
 0.99A 4a97B-2cjsA:
undetectable
4a97C-2cjsA:
undetectable		 4a97B-2cjsA:
19.74
4a97C-2cjsA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2cjs REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
UNC-13 HOMOLOG A
(Rattus
norvegicus) 		4 / 6 GLY A   7
ARG A  86
GLU A 128
ARG C 118
 EDO  A1156 (-3.2A)
None
None
None
 1.32A 4bqfA-2cjsA:
undetectable		 4bqfA-2cjsA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		4 / 6 PHE A  20
THR A  22
ASP A  72
GLY A  68
 None
None
GOL  A1158 ( 4.1A)
None
 1.05A 5mraA-2cjsA:
undetectable
5mraB-2cjsA:
undetectable		 5mraA-2cjsA:
21.89
5mraB-2cjsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2cjs UNC-13 HOMOLOG A
(Rattus
norvegicus) 		5 / 9 PHE A  51
VAL A  28
ILE A   0
LEU A   1
ARG A  55
 None
 1.32A 6c2mC-2cjsA:
undetectable		 6c2mC-2cjsA:
21.21