SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2cjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 7 VAL A 189
ILE A 218
HIS A  99
LEU A 118
 None
 0.93A 1j96B-2cjwA:
2.5		 1j96B-2cjwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 8 ALA A 125
TYR A  76
LEU A 118
GLY A 234
 None
 0.86A 1rukH-2cjwA:
undetectable
1rukL-2cjwA:
undetectable		 1rukH-2cjwA:
19.83
1rukL-2cjwA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 12 PHE A 232
THR A 220
GLY A 234
ILE A 218
VAL A 239
 None
 1.16A 1vq1A-2cjwA:
undetectable		 1vq1A-2cjwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 9 VAL A  86
GLY A  82
LEU A 154
LEU A 129
ASP A 131
 GDP  A 999 (-4.1A)
None
None
None
MG  A1000 ( 4.1A)
 1.01A 2j2pB-2cjwA:
0.0
2j2pC-2cjwA:
0.0		 2j2pB-2cjwA:
21.15
2j2pC-2cjwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		5 / 8 LEU A  91
LEU A 231
ILE A 127
VAL A  78
LEU A 154
 None
 1.43A 3kp6A-2cjwA:
undetectable
3kp6B-2cjwA:
undetectable		 3kp6A-2cjwA:
24.27
3kp6B-2cjwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 6 LYS A 210
LEU A 188
ARG A 176
PHE A 213
 CAS  A 209 ( 3.0A)
CAS  A 215 ( 4.5A)
CAS  A 215 ( 4.4A)
CAS  A 209 (-4.6A)
 1.02A 4uswA-2cjwA:
undetectable		 4uswA-2cjwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		4 / 7 VAL A 189
ILE A 218
HIS A  99
LEU A 118
 None
 0.98A 4xo7A-2cjwA:
2.5		 4xo7A-2cjwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		3 / 3 LEU A  91
LEU A 231
ARG A  77
 None
 0.63A 5hnzB-2cjwA:
2.1		 5hnzB-2cjwA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		3 / 3 LEU A 171
GLN A 174
LYS A  88
 None
None
GDP  A 999 (-2.7A)
 0.83A 6exiB-2cjwA:
undetectable		 6exiB-2cjwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2cjw GTP-BINDING PROTEIN
GEM
(Homo
sapiens) 		3 / 3 LEU A 171
GLN A 174
LYS A  88
 None
None
GDP  A 999 (-2.7A)
 0.84A 6exiA-2cjwA:
2.3		 6exiA-2cjwA:
20.69