SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ck0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 2ck0 PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)
(Mus
musculus) 		4 / 4 THR H 121
PRO H 151
THR H 120
PRO H 122
 None
 1.30A 1dsdC-2ck0H:
undetectable		 1dsdC-2ck0H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 2ck0 PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)
(Mus
musculus) 		4 / 4 THR H 121
PRO H 151
THR H 120
PRO H 122
 None
 1.30A 1dsdC-2ck0H:
undetectable		 1dsdC-2ck0H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 2ck0 HEAVY CHAIN)
PROTEIN
(IMMUNOGLOBULIN
(Mus
musculus) 		5 / 12 LEU H 142
VAL H 167
GLY H 161
VAL H 187
VAL H 185
 None
 0.94A 2ieoB-2ck0H:
undetectable		 2ieoB-2ck0H:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 2ck0 HEAVY CHAIN)
PROTEIN
(IMMUNOGLOBULIN
(Mus
musculus) 		5 / 12 CYH H  22
ALA H  24
MET H  34
ARG H  71
TYR H 106
 None
 1.15A 3qxvE-2ck0H:
16.7		 3qxvE-2ck0H:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2ck0 HEAVY CHAIN)
PROTEIN
(IMMUNOGLOBULIN
(Mus
musculus) 		4 / 6 CYH H 199
THR H 198
CYH H 144
GLY H 143
 None
 1.30A 3w9tE-2ck0H:
undetectable		 3w9tE-2ck0H:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 2ck0 PROTEIN
(IMMUNOGLOBULIN
HEAVY CHAIN)
(Mus
musculus) 		5 / 5 SER H 116
ALA H 118
PHE H 150
LEU H 174
ASP H 177
 None
 0.68A 5mthA-2ck0H:
27.3		 5mthA-2ck0H:
67.71