SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ck2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 2ck2 HUMAN FIBRONECTIN
(Homo
sapiens) 		4 / 7 THR A  58
TYR A  57
TYR A  36
LEU A  34
 None
 1.06A 1qzrA-2ck2A:
undetectable		 1qzrA-2ck2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 2ck2 HUMAN FIBRONECTIN
(Homo
sapiens) 		4 / 7 THR A  58
TYR A  57
TYR A  36
LEU A  34
 None
 1.07A 1qzrB-2ck2A:
undetectable		 1qzrB-2ck2A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 2ck2 HUMAN FIBRONECTIN
(Homo
sapiens) 		5 / 6 PHE A  92
ALA A  18
PRO A  64
LEU A  62
THR A  16
 None
 1.39A 4dtzA-2ck2A:
undetectable		 4dtzA-2ck2A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2ck2 HUMAN FIBRONECTIN
(Homo
sapiens) 		5 / 10 PRO A  87
LEU A  34
ILE A  59
ALA A  18
PHE A  92
 None
 1.36A 5m0oA-2ck2A:
undetectable		 5m0oA-2ck2A:
11.93