SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ckf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 2ckf RING-HYDROXYLATING
DIOXYGENASE BETA
SUBUNIT
(Sphingomonas
sp.
CHY-1) 		5 / 12 GLY B  30
ILE B  99
PHE B 173
TYR B 101
ARG B  84
 None
 1.36A 4kotA-2ckfB:
undetectable		 4kotA-2ckfB:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ckf RING-HYDROXYLATING
DIOXYGENASE BETA
SUBUNIT
(Sphingomonas
sp.
CHY-1) 		4 / 7 ILE B 159
GLY B 139
LEU B  78
ASP B 142
 None
 0.89A 5hieB-2ckfB:
undetectable		 5hieB-2ckfB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2ckf RING-HYDROXYLATING
DIOXYGENASE BETA
SUBUNIT
(Sphingomonas
sp.
CHY-1) 		4 / 8 LEU B 158
TYR B  46
ILE B  44
LEU B  26
 None
 0.76A 5y7pC-2ckfB:
undetectable		 5y7pC-2ckfB:
19.94