SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ckh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 10 MET A 604
ALA A 610
LEU A 478
MET A 477
ILE A 637
 None
 1.29A 1a52A-2ckhA:
undetectable		 1a52A-2ckhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 10 MET A 604
ALA A 610
LEU A 478
MET A 477
ILE A 637
 None
 1.29A 1a52B-2ckhA:
undetectable		 1a52B-2ckhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 7 CYH A 535
HIS A 533
GLY A 554
GLY A 553
 None
 0.88A 1ekjE-2ckhA:
undetectable
1ekjF-2ckhA:
undetectable		 1ekjE-2ckhA:
18.18
1ekjF-2ckhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 8 GLN A 596
CYH A 535
GLY A 553
GLY A 554
 None
 0.78A 1ekjE-2ckhA:
undetectable
1ekjF-2ckhA:
undetectable		 1ekjE-2ckhA:
18.18
1ekjF-2ckhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 8 CYH A 535
HIS A 533
GLY A 554
GLY A 553
 None
 0.89A 1ekjG-2ckhA:
undetectable
1ekjH-2ckhA:
undetectable		 1ekjG-2ckhA:
18.18
1ekjH-2ckhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 7 GLY A 554
ILE A 555
ALA A 537
ILE A 528
 None
 0.68A 1n49A-2ckhA:
undetectable		 1n49A-2ckhA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 536
LEU A 525
ILE A 593
SER A 482
VAL A 521
 None
 1.19A 2po7A-2ckhA:
undetectable		 2po7A-2ckhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 LEU A 536
LEU A 525
ILE A 593
SER A 482
VAL A 521
 None
 1.18A 2po7B-2ckhA:
undetectable		 2po7B-2ckhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 MET A 475
HIS A 491
ASN A 472
PRO A 527
LEU A 536
 None
 1.23A 3tm4A-2ckhA:
undetectable		 3tm4A-2ckhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 MET A 475
HIS A 491
ASN A 472
PRO A 527
LEU A 536
 None
 1.23A 3tm4B-2ckhA:
undetectable		 3tm4B-2ckhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 ASP A 616
ILE A 523
VAL A 521
MET A 475
LEU A 478
 None
 1.26A 4a84A-2ckhA:
undetectable		 4a84A-2ckhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 5 LEU A 643
ARG A 632
ILE A 637
ASN A 476
 None
 1.08A 4i00A-2ckhA:
undetectable		 4i00A-2ckhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 7 LEU A 466
LEU A 536
MET A 626
ILE A 528
 None
 1.03A 4okwA-2ckhA:
undetectable		 4okwA-2ckhA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2ckh SMALL
UBIQUITIN-RELATED
MODIFIER 2
(Homo
sapiens) 		3 / 3 GLU B  80
LYS B  20
ASN B  18
 None
 1.01A 4y1dA-2ckhB:
1.7
4y1dD-2ckhB:
undetectable		 4y1dA-2ckhB:
18.56
4y1dD-2ckhB:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		4 / 6 ASP A 540
ASN A 557
ASN A 545
GLN A 585
 None
 1.12A 5l6eA-2ckhA:
undetectable		 5l6eA-2ckhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 PHE A 497
LEU A 567
LEU A 563
ILE A 562
VAL A 518
 None
 1.38A 5uanB-2ckhA:
undetectable		 5uanB-2ckhA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 12 VAL A 509
LEU A 567
PHE A 493
LEU A 524
VAL A 526
 None
 1.30A 6a93B-2ckhA:
undetectable		 6a93B-2ckhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		3 / 3 TYR A 549
ALA A 559
LEU A 563
 None
 0.61A 6ag0C-2ckhA:
undetectable		 6ag0C-2ckhA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		5 / 10 MET A 604
ALA A 610
LEU A 478
MET A 477
ILE A 637
 None
 1.37A 6cbzB-2ckhA:
undetectable		 6cbzB-2ckhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ckh SENTRIN-SPECIFIC
PROTEASE 1
(Homo
sapiens) 		3 / 3 ARG A 632
PHE A 605
PHE A 420
 None
 0.93A 6nknC-2ckhA:
undetectable
6nknJ-2ckhA:
undetectable		 6nknC-2ckhA:
19.12
6nknJ-2ckhA:
16.35