SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ckr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		5 / 11 ILE A 292
ALA A 276
ILE A 272
SER A 300
ILE A 293
 None
 1.20A 1dg5A-2ckrA:
undetectable		 1dg5A-2ckrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.00A 1p6kB-2ckrA:
undetectable		 1p6kB-2ckrA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 0.94A 1rs6B-2ckrA:
undetectable		 1rs6B-2ckrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.02A 1rs7B-2ckrA:
undetectable		 1rs7B-2ckrA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 0.97A 1zzuA-2ckrA:
0.7		 1zzuA-2ckrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.01A 1zzuB-2ckrA:
undetectable		 1zzuB-2ckrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 6 ILE A 184
ARG A 216
LEU A 175
LEU A 209
 None
ZN  A1433 ( 4.7A)
None
None
 1.08A 2rlfA-2ckrA:
undetectable
2rlfD-2ckrA:
undetectable		 2rlfA-2ckrA:
10.76
2rlfD-2ckrA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 4 PRO A 232
TYR A 275
GLY A 295
THR A 296
 None
 1.46A 3ib0A-2ckrA:
undetectable		 3ib0A-2ckrA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		3 / 3 HIS A 225
PHE A 242
PHE A 243
 None
 0.47A 3lk0D-2ckrA:
undetectable		 3lk0D-2ckrA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.08A 3n62A-2ckrA:
0.7		 3n62A-2ckrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.04A 3n62B-2ckrA:
undetectable		 3n62B-2ckrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.09A 3n66B-2ckrA:
undetectable		 3n66B-2ckrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 PRO A 264
HIS A 225
ILE A 226
ILE A 260
 None
 0.99A 3sfeB-2ckrA:
undetectable
3sfeC-2ckrA:
undetectable		 3sfeB-2ckrA:
19.87
3sfeC-2ckrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		5 / 12 GLN A 422
PHE A 401
THR A 405
GLY A 410
GLY A 414
 None
 1.18A 3tegA-2ckrA:
undetectable		 3tegA-2ckrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 7 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.10A 4kcnB-2ckrA:
0.9		 4kcnB-2ckrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 5 ASN A 262
HIS A 225
GLU A 259
THR A 354
 None
 1.43A 4p6sA-2ckrA:
0.9		 4p6sA-2ckrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		5 / 9 SER A 187
GLY A 295
GLU A 263
ILE A 260
ALA A 276
 None
 1.19A 5entC-2ckrA:
undetectable		 5entC-2ckrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.13A 5vuoB-2ckrA:
undetectable		 5vuoB-2ckrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		3 / 3 THR A 354
GLU A 259
HIS A 225
 None
 0.91A 5xiqB-2ckrA:
undetectable		 5xiqB-2ckrA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		3 / 3 TYR A 258
HIS A 250
MET A 206
 None
 1.21A 6af6A-2ckrA:
undetectable		 6af6A-2ckrA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ckr ENDOGLUCANASE E-5
(Thermobifida
fusca) 		4 / 8 SER A 392
GLN A 402
PHE A 401
ASN A 390
 None
 1.11A 6auuB-2ckrA:
undetectable		 6auuB-2ckrA:
20.45