SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ckx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.19A 1f86B-2ckxA:
undetectable		 1f86B-2ckxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 5 LEU A 619
VAL A 617
ARG A 601
THR A 615
 None
 1.47A 1nw3A-2ckxA:
undetectable		 1nw3A-2ckxA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 6 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.20A 1sn5A-2ckxA:
undetectable		 1sn5A-2ckxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.31A 2roxA-2ckxA:
undetectable		 2roxA-2ckxA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 6 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.17A 4d7bB-2ckxA:
undetectable		 4d7bB-2ckxA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.25A 6gnrA-2ckxA:
undetectable		 6gnrA-2ckxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2ckx TELOMERE BINDING
PROTEIN TBP1
(Nicotiana
tabacum) 		4 / 4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.24A 6gnrB-2ckxA:
undetectable		 6gnrB-2ckxA:
19.42