SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2clb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2clb DPS-LIKE PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 LEU A  26
GLU A 156
ALA A 149
THR A 145
 None
ZN  A1175 ( 2.3A)
None
None
 0.82A 1ie4B-2clbA:
undetectable
1ie4D-2clbA:
undetectable		 1ie4B-2clbA:
18.95
1ie4D-2clbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2clb DPS-LIKE PROTEIN
(Sulfolobus
solfataricus) 		4 / 8 LEU A 117
ALA A  63
ILE A  62
GLY A  56
 None
 0.81A 1sv9A-2clbA:
undetectable		 1sv9A-2clbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2clb DPS-LIKE PROTEIN
(Sulfolobus
solfataricus) 		5 / 9 LEU A  26
GLU A 133
ALA A  33
GLU A 156
LEU A 153
 None
None
None
ZN  A1175 ( 2.3A)
None
 1.34A 2azqA-2clbA:
undetectable		 2azqA-2clbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2clb DPS-LIKE PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 THR A 130
VAL A 134
GLU A 156
 None
None
ZN  A1175 ( 2.3A)
 0.77A 3v4tA-2clbA:
undetectable
3v4tD-2clbA:
undetectable		 3v4tA-2clbA:
18.76
3v4tD-2clbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2clb DPS-LIKE PROTEIN
(Sulfolobus
solfataricus) 		3 / 3 SER A  99
ALA A 100
THR A 130
 None
 0.71A 5n0xB-2clbA:
undetectable		 5n0xB-2clbA:
19.22