SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2clp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 6 TYR A 285
ALA A 289
ALA A 295
THR A 296
 None
 0.84A 3b6hA-2clpA:
undetectable		 3b6hA-2clpA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 8 LEU A  92
THR A 105
VAL A 101
GLY A  95
 None
 0.71A 3dcjB-2clpA:
undetectable		 3dcjB-2clpA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 11 LEU A 350
GLU A 272
MET A 292
GLY A 236
LEU A 233
 None
CA  A1362 (-4.3A)
None
None
None
 1.38A 3hm1B-2clpA:
undetectable		 3hm1B-2clpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 8 LEU A 216
CYH A 215
TYR A 197
PHE A 223
 None
 1.34A 3po7A-2clpA:
undetectable		 3po7A-2clpA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 12 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.16A 3qxyA-2clpA:
undetectable		 3qxyA-2clpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 11 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.13A 3qxyB-2clpA:
undetectable
3qxyQ-2clpA:
undetectable		 3qxyB-2clpA:
21.12
3qxyQ-2clpA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 11 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.14A 3rc0A-2clpA:
undetectable		 3rc0A-2clpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 12 VAL A 314
ALA A 313
TYR A 140
TYR A 197
PHE A 223
 None
 1.14A 3rc0B-2clpA:
undetectable		 3rc0B-2clpA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 11 THR A  74
LEU A  94
VAL A 101
VAL A  60
THR A  61
 None
 1.32A 3tbgA-2clpA:
undetectable		 3tbgA-2clpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 8 VAL A  77
TYR A  78
HIS A 142
TRP A 257
 None
NDP  A1361 (-4.9A)
NDP  A1361 (-3.7A)
None
 0.65A 4jq1B-2clpA:
23.6		 4jq1B-2clpA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 8 VAL A  77
TYR A  78
HIS A 142
TRP A 257
 None
NDP  A1361 (-4.9A)
NDP  A1361 (-3.7A)
None
 0.87A 4jtrA-2clpA:
23.5		 4jtrA-2clpA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		4 / 7 PHE A 223
LEU A 216
VAL A 208
PHE A 359
 None
 0.92A 4wnvD-2clpA:
undetectable		 4wnvD-2clpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 9 LEU A 115
THR A 153
LEU A 154
ILE A 182
LEU A 185
 None
 1.25A 5g48B-2clpA:
undetectable		 5g48B-2clpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens) 		5 / 9 THR A 296
THR A 293
LEU A 234
ILE A 274
LEU A 233
 None
NDP  A1361 ( 3.9A)
None
None
None
 1.33A 5g48B-2clpA:
undetectable		 5g48B-2clpA:
21.20